Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer (Q37855730)

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scientific article published on 21 March 2011

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English	Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer	scientific article published on 21 March 2011

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scholarly article

1 reference

Europe PubMed Central

24 August 2017

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Europe PubMed Central

Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer (English)

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Europe PubMed Central

24 August 2017

ribonucleoprotein complex

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

author name string

Leena Latonen

1

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Europe PubMed Central

24 August 2017

language of work or name

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publication date

21 March 2011

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Europe PubMed Central

24 August 2017

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Europe PubMed Central

24 August 2017

33

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Europe PubMed Central

24 August 2017

5

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Europe PubMed Central

24 August 2017

386-395

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Europe PubMed Central

24 August 2017

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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The 26 S proteasome: from basic mechanisms to drug targeting

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Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

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21 January 2018

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

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21 January 2018

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

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https://api.crossref.org/works/10.1002%2FBIES.201100008

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Nonproteolytic functions of ubiquitin in cell signaling

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Polyubiquitin binding and disassembly by deubiquitinating enzymes

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Intracellular localization of proteasomes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Protein degradation and protection against misfolded or damaged proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The ubiquitin proteasome system in neuropathology

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Aggresomes: a cellular response to misfolded proteins

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Formation of nuclear HSF1 granules varies depending on stress stimuli

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitors: from research tools to drug candidates

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolus: from structure to dynamics

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https://api.crossref.org/works/10.1002%2FBIES.201100008

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The multifunctional nucleolus

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https://api.crossref.org/works/10.1002%2FBIES.201100008

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Nucleolus: the fascinating nuclear body

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https://api.crossref.org/works/10.1002%2FBIES.201100008

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Nucleolar proteome dynamics

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The nucleolus under stress

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 localizes to intranucleolar regions distinct from the ribosome production compartments.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

CRM1-mediated nuclear export: to the pore and beyond.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The many pathways of RNA degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Polyadenylation of ribosomal RNA in human cells

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

A role for ubiquitin in the clearance of nonfunctional rRNAs

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Potential roles for ubiquitin and the proteasome during ribosome biogenesis

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

A proteomics approach to understanding protein ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The ARF/p53 pathway

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The multiple levels of regulation by p53 ubiquitination

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies

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21 January 2018

Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Alphavirus M1 induces apoptosis of malignant glioma cells via downregulation and nucleolar translocation of p21WAF1/CIP1 protein

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

SUMO on the road to neurodegeneration

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Molecular mechanisms and potential therapeutical targets in Huntington's disease

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21 January 2018

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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21 January 2018

The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy.

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21 January 2018

Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci.

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21 January 2018

Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.

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21 January 2018

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

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21 January 2018

RNA association and nucleocytoplasmic shuttling by ataxin-1

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21 January 2018

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

1 reference

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21 January 2018

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

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21 January 2018

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci

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21 January 2018

Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n

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21 January 2018

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10

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21 January 2018

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

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21 January 2018

FRG1P-mediated aggregation of proteins involved in pre-mRNA processing

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21 January 2018

Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA

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21 January 2018

Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus

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21 January 2018

Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment

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https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5.

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21 January 2018

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

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21 January 2018

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

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21 January 2018

Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.

1 reference

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21 January 2018

Intracellular trafficking of heat shock factor 2

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21 January 2018

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

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21 January 2018

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

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21 January 2018

Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination

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21 January 2018

Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress

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21 January 2018

Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteomic characterization of aggregating proteins after the inhibition of the ubiquitin proteasome system

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation.

1 reference

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21 January 2018

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Identifiers

10.1002/BIES.201100008

1 reference

Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

24 August 2017

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