The multifaceted roles of USP7: new therapeutic opportunities (Q37862125)

24 August 2017

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title

The multifaceted roles of USP7: new therapeutic opportunities (English)

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24 August 2017

Benjamin Nicholson

1

1 reference

PubMed ID

21468693

24 August 2017

K G Suresh Kumar

series ordinal

2

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24 August 2017

1 June 2011

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Cell Biochemistry and Biophysics

24 August 2017

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24 August 2017

60

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24 August 2017

1-2

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24 August 2017

61-68

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https://scigraph.springernature.com/pub.10.1007/s12013-011-9185-5

24 August 2017

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1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Deubiquitinating enzymes as novel anticancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Targeting ubiquitin specific proteases for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Defining the human deubiquitinating enzyme interaction landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

A dynamic role of HAUSP in the p53-Mdm2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Inactivation of HAUSP in vivo modulates p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Ubiquitination regulates PTEN nuclear import and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Dynamic FoxO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Mdm2 induces mono-ubiquitination of FOXO4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Guanosine-5′-phosphate synthetase and guanosine-5′-phosphate kinase in rat hepatomas and kidney tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Herpes simplex virus ICP0 mutants are hypersensitive to interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

ICP0 dismantles microtubule networks in herpes simplex virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

HSV ICP0 recruits USP7 to modulate TLR-mediated innate response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Isolation of human sequences that replicate autonomously in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Reverse the curse--the role of deubiquitination in cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

DNA damage checkpoints: from initiation to recovery or adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Cell cycle kinases as therapeutic targets for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Chfr is linked to tumour metastasis through the downregulation of HDAC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

Detection and characterization of SUMO protease activity using a sensitive enzyme-based reporter assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-011-9185-5

10.1007/S12013-011-9185-5

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21468693