Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications (Q37894572)

24 August 2017

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title

Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications (English)

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24 August 2017

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Brian J Arey

1

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PubMed ID

21706143

24 August 2017

Francisco J López

series ordinal

2

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24 August 2017

1 December 2011

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Reviews in Endocrine and Metabolic Disorders

24 August 2017

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24 August 2017

12

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24 August 2017

4

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24 August 2017

275-288

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https://scigraph.springernature.com/pub.10.1007/s11154-011-9188-y

24 August 2017

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Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide

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Comparison of the biological and immunological properties of glycosylation deficient human chorionic gonadotropin variants produced by site directed mutagenesis and chemical deglycosylation

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The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA

21 January 2018

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The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

21 January 2018

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Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function

21 January 2018

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The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

21 January 2018

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Ligand-induced receptor dimerization may be critical for signal transduction by choriogonadotropin

21 January 2018

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Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing

21 January 2018

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Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.

21 January 2018

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GIPC Binds to the Human Lutropin Receptor (hLHR) through an Unusual PDZ Domain Binding Motif, and It Regulates the Sorting of the Internalized Human Choriogonadotropin and the Density of Cell Surface hLHR

21 January 2018

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Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling

21 January 2018

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Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site

21 January 2018

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The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization

21 January 2018

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Is there any physiological role for gonadotrophin oligosaccharide heterogeneity in humans? II. A biochemical point of view

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Differing pharmacological activities of thiazolidinone analogs at the FSH receptor

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Functional selectivity through protean and biased agonism: who steers the ship?

21 January 2018

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Impact of Carbohydrate Heterogeneity in Function of Follicle-Stimulating Hormone: Studies Derived from in Vitro and in Vivo Models1

21 January 2018

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Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o).

21 January 2018

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The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals

21 January 2018

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

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beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor

21 January 2018

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Studies with chimeras of the gonadotropin receptors reveal the importance of third intracellular loop threonines on the formation of the receptor/nonvisual arrestin complex

21 January 2018

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Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

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Transactivation joins multiple tracks to the ERK/MAPK cascade

21 January 2018

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Synthesis of biologically active canine CCK-58.

21 January 2018

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Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

21 January 2018

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Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58.

21 January 2018

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Chromatofocusing fails to separate hFSH isoforms on the basis of glycan structure

21 January 2018

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Inhibition of phosphoinositide metabolism or chelation of intracellular calcium blocks FSH-induced but not spontaneous meiotic resumption in mouse oocytes.

21 January 2018

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FSH directly regulates bone mass

21 January 2018

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Selective modulation of follicle-stimulating hormone signaling pathways with enhancing equine chorionic gonadotropin/antibody immune complexes

21 January 2018

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The oligosaccharides of influenza virus hemagglutinin expressed in insect cells by a baculovirus vector

21 January 2018

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The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation

21 January 2018

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Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand

21 January 2018

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Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists

21 January 2018

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Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists

21 January 2018

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Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor

21 January 2018

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A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

21 January 2018

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A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo

21 January 2018

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A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

21 January 2018

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Stimulation of ovarian follicular maturation with pure follicle-stimulating hormone in women with gonadotropin deficiency

21 January 2018

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Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor

21 January 2018

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[3H]Org 43553, the first low-molecular-weight agonistic and allosteric radioligand for the human luteinizing hormone receptor

21 January 2018

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Hormonal treatment of male infertility: FSH.

21 January 2018

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21 January 2018

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Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone

21 January 2018

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Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

21 January 2018

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Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene

21 January 2018

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Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

21 January 2018

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Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse

21 January 2018

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21 January 2018

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Recombinant FSH in the treatment of oligozoospermia

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Structural organization of the follicle-stimulating hormone receptor gene

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12 December 2020

Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist.

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Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms

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Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction

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Is deglycosylated human chorionic gonadotropin an antagonist to human chorionic gonadotropin? Characterization of deglycosylated human chorionic gonadotropin action in two testicular interstitial cell fractions

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A1 adenosine receptors of bovine brain couple to guanine nucleotide-binding proteins Gi1, Gi2, and Go.

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12 December 2020

Multiple species of FSH are present within hamster anterior pituitary cells cultured in vitro

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12 December 2020

Is FSH required for adult spermatogenesis?

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The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction

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Receptor binding and signal transduction are dissociable functions requiring different sites on follicle-stimulating hormone

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Identification and characterization of a selective, nonpeptide follicle-stimulating hormone receptor antagonist

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Comparison of controlled ovarian stimulation with human menopausal gonadotropin or recombinant follicle-stimulating hormone

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Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients

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Male reproductive phenotypes in double mutant mice lacking both FSHbeta and activin receptor IIA

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Site-directed mutagenesis defines the individual roles of the glycosylation sites on follicle-stimulating hormone

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12 December 2020

Use of exogenous gonadotropins in anovulatory women: a technical bulletin

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12 December 2020

17 beta-oestradiol counteracts the formation of the more acidic isoforms of follicle-stimulating hormone and luteinizing hormone after menopause

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Induction of final follicular maturation and early luteinization in women undergoing ovulation induction for assisted reproduction treatment--recombinant HCG versus urinary HCG. The European Recombinant Human Chorionic Gonadotrophin Study Group

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Luteinizing hormone receptors are self-associated in the plasma membrane

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Co-purification of A1 adenosine receptors and guanine nucleotide-binding proteins from bovine brain

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N-linked carbohydrates on G protein-coupled receptors: mapping sites of attachment and determining functional roles

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12 December 2020

Human chorionic gonadotropin activates the inositol 1,4,5-trisphosphate-Ca2+ intracellular signalling system in bovine luteal cells

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12 December 2020

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Serum hyperglycosylated hCG: a potential screening test for fetal Down syndrome

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A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation

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The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction

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Isolated deficiency of follicle-stimulating hormone re-revisited

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12 December 2020

Effect of chronic daily oral administration of 17 beta-oestradiol and norethisterone on the isoforms of serum gonadotrophins in post-menopausal women

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Modulation of serum follicle-stimulating hormone bioactivity and isoform distribution by estrogenic steroids in normal women and in gonadal dysgenesis

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Low-dose human chorionic gonadotropin therapy can improve sensitivity to exogenous follicle-stimulating hormone in patients with secondary amenorrhea

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12 December 2020

Sexual maturation in female rats: time-related changes in the isoelectric focusing pattern of anterior pituitary follicle-stimulating hormone

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Human chorionic gonadotropin Molecular forms, detection, and clinical implications

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The lutropin/choriogonadotropin receptor, a 2002 perspective

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12 December 2020

10.1007/S11154-011-9188-Y

Identifiers

DOI

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release_zupzxjguhzdiveonorzth4bnkq

24 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/zupzxjguhzdiveonorzth4bnkq

24 November 2022

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PubMed ID

21706143

1 reference

PubMed ID

21706143