Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism (Q37924942)

25 August 2017

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title

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism (English)

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25 August 2017

4

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25 August 2017

C Benedict

2

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author name string

V Ott

series ordinal

1

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PubMed ID

21883804

25 August 2017

B Schultes

series ordinal

3

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PubMed ID

21883804

25 August 2017

M Hallschmid

series ordinal

5

1 reference

25 August 2017

16 November 2011

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Diabetes, Obesity and Metabolism

25 August 2017

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25 August 2017

14

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25 August 2017

3

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25 August 2017

214-221

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Insulin receptors are widely distributed in the central nervous system of the rat

25 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Ontogenesis of insulin receptors in human cerebral cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Localization of insulin receptor mRNA in rat brain by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin expression in the brain and pituitary cells of tilapia (Oreochromis niloticus).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Role of brain insulin receptor in control of body weight and reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hypothalamic K(ATP) channels control hepatic glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin receptor signaling in the development of neuronal structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Monitoring of stored and available fuel by the CNS: implications for obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central control of body weight and appetite

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central administration of insulin suppresses food intake in chicks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Differential sensitivity to central leptin and insulin in male and female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Neuroendocrine responses to hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Brain uptake of intranasally applied radioiodinated leptin in Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Transport of drugs from the nasal cavity to the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal delivery to the central nervous system: mechanisms and experimental considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Inhaled insulin-intrapulmonary, intranasal, and other routes of administration: mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

New strategies to improve the intranasal absorption of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central nervous system effects of intranasally administered insulin during euglycemia in men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin and hippocampus activation in response to images of high-calorie food in normal weight and obese adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin modulates food-related activity in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Synaptic mechanisms for plasticity in neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin and neurodegenerative disease: shared and specific mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin improves memory in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin improves memory in humans: superiority of insulin aspart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Age at onset and regional cerebral glucose metabolism in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central nervous system control of food intake and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin therapy and type 2 diabetes: management of weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin-associated weight gain in diabetes--causes, effects and coping strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Brain insulin controls adipose tissue lipolysis and lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The role of hepatic insulin receptors in the regulation of glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin's direct effects on the liver dominate the control of hepatic glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Insulin enhances glucose-stimulated insulin secretion in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Obese men respond to cognitive but not to catabolic brain insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Diabetes, obesity, and the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central obesity and increased risk of dementia more than three decades later

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Metabolic syndrome and cognitive decline in French elders: the Three-City Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Cognitive dysfunction and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

ApoE genotype accounts for the vast majority of AD risk and AD pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

An obesity-associated FTO gene variant and increased energy intake in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hypothalamic insulin signaling is required for inhibition of glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Glucocorticoids, chronic stress, and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Glucocorticoids and the ageing hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01490.X

10.1111/J.1463-1326.2011.01490.X

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21883804