Genetic variants in candidate genes influencing NAFLD progression (Q37926957)

25 August 2017

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title

Genetic variants in candidate genes influencing NAFLD progression (English)

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25 August 2017

Michelino Di Rosa

1

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PubMed ID

21894552

25 August 2017

Lucia Malaguarnera

series ordinal

2

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25 August 2017

6 September 2011

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Journal of Molecular Medicine

25 August 2017

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25 August 2017

90

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25 August 2017

105-118

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25 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00109-011-0803-x

25 August 2017

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cites work

Nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Molecular mechanisms involved in NAFLD progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetics of alcoholic liver disease and nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Nonalcoholic fatty liver disease: from steatosis to cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Lipid metabolism in hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Inflammatory mediators of hepatic steatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Role of adipocytokines in hepatic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Plasma adiponectin is decreased in nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Kinetic complexity of the global response to glucocorticoid receptor action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: roles of MAPKerk and MAPKp38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Association of apolipoprotein E polymorphisms in patients with non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Apolipoprotein E gene polymorphism in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetic variance in the adiponutrin gene family and childhood obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

A feed-forward loop amplifies nutritional regulation of PNPLA3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The mechanisms of action of PPARs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Efficacy of 5 MU of interferon in combination with ribavirin for naïve patients with chronic hepatitis C virus: a randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Synthesis and processing of the precursor for human mangano-superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Ethnic variation in the mitochondrial targeting sequence polymorphism of MnSOD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Alpha 1-antitrypsin mutations in NAFLD: high prevalence and association with altered iron metabolism but not with liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0803-X

Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis.

21 January 2018

1 reference

12 December 2020

Associations of serum TRAIL concentrations, anthropometric variables, and serum lipid parameters in healthy adults.

1 reference

12 December 2020

Tumor necrosis factor--alpha gene promoter polymorphisms in Chinese patients with nonalcoholic fatty liver diseases

1 reference

12 December 2020

sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease

1 reference

12 December 2020

Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin

1 reference

12 December 2020

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

1 reference

12 December 2020

Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?

1 reference

12 December 2020

Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation

1 reference

12 December 2020

An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat

1 reference

12 December 2020

Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

1 reference

12 December 2020

Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis

1 reference

12 December 2020

Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.

1 reference

12 December 2020

Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells.

1 reference

12 December 2020

Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease

1 reference

12 December 2020

Nonalcoholic steatohepatitis: risk factors for liver fibrosis

1 reference

12 December 2020

The relationship between apolipoprotein E polymorphism, lipoprotein (a) and fatty liver disease.

1 reference

12 December 2020

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

1 reference

12 December 2020

Tumor necrosis factor α −238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus

1 reference

12 December 2020

Does the SLC40A1 gene modify HFE-related haemochromatosis phenotypes?

1 reference

12 December 2020

Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men

1 reference

12 December 2020

10.1007/S00109-011-0803-X

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21894552