Molecular mechanisms involved in NAFLD progression (Q37437295)

20 August 2017

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title

Molecular mechanisms involved in NAFLD progression (English)

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20 August 2017

Ferdinando Nicoletti

3

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ORCID Public Data File 2021

author name string

Mariano Malaguarnera

series ordinal

1

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20 August 2017

Michelino Di Rosa

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2

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20 August 2017

Lucia Malaguarnera

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4

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20 August 2017

8 April 2009

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Journal of Molecular Medicine

20 August 2017

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20 August 2017

87

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20 August 2017

679-695

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20 August 2017

7

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https://scigraph.springernature.com/pub.10.1007/s00109-009-0464-1

20 August 2017

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cites work

IRS proteins and the common path to diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Effect of peroxisome proliferator-activated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-009-0464-1

Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.

21 January 2018

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12 December 2020

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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12 December 2020

Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions.

1 reference

12 December 2020

The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis

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12 December 2020

The effect of a silybin-vitamin e-phospholipid complex on nonalcoholic fatty liver disease: a pilot study

1 reference

12 December 2020

Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes

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12 December 2020

Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis?

1 reference

12 December 2020

Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice.

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12 December 2020

Role of Kupffer cells in host defense and liver disease

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12 December 2020

PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.

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12 December 2020

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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12 December 2020

Chitotriosidase: the yin and yang

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12 December 2020

The heme oxygenase-carbon monoxide system: a regulator of hepatobiliary function

1 reference

12 December 2020

Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction

1 reference

12 December 2020

Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism.

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12 December 2020

Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.

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12 December 2020

Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis

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12 December 2020

Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet.

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12 December 2020

Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1.

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12 December 2020

From fat to inflammation

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12 December 2020

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

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12 December 2020

Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

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12 December 2020

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

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12 December 2020

Mitochondrial Glutathione: Importance and Transport

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12 December 2020

Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages.

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12 December 2020

Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.

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12 December 2020

GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex

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12 December 2020

IKK-beta links inflammation to obesity-induced insulin resistance

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12 December 2020

Apolipoprotein synthesis in nonalcoholic steatohepatitis

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12 December 2020

Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis

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12 December 2020

Action of prolactin, IFN-γ, TNF-α and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages

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12 December 2020

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

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12 December 2020

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

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12 December 2020

A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.

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12 December 2020

The heme oxygenase system: its role in liver inflammation

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12 December 2020

Interaction of liver methionine adenosyltransferase with hydroxyl radical

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12 December 2020

Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.

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12 December 2020

The impact of pregnane X receptor activation on liver fibrosis

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12 December 2020

Current pharmacological treatment of nonalcoholic fatty liver

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12 December 2020

Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH).

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12 December 2020

Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines

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12 December 2020

A prospective study of acute drug-induced liver injury in patients suffering from non-alcoholic fatty liver disease.

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12 December 2020

Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis.

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12 December 2020

Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

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12 December 2020

Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2

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12 December 2020

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

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12 December 2020

Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance

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12 December 2020

Safety of statin therapy in patients with preexisting liver disease

1 reference

12 December 2020

Mitochondria in steatohepatitis

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12 December 2020

Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis.

1 reference

12 December 2020

Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways

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12 December 2020

Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress.

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12 December 2020

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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12 December 2020

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

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12 December 2020

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

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12 December 2020

Telmisartan, an angiotensin II type 1 receptor blocker, controls progress of nonalcoholic steatohepatitis in rats

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12 December 2020

The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

1 reference

12 December 2020

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

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12 December 2020

The role of GSK3 in glucose homeostasis and the development of insulin resistance

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12 December 2020

Nonalcoholic fatty liver disease

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12 December 2020

Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter

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12 December 2020

Nrf1 gene expression in the liver: a single gene linking oxidative stress to NAFLD, NASH and hepatic tumours

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12 December 2020

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

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12 December 2020

Insulin resistance: a metabolic pathway to chronic liver disease

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12 December 2020

Probiotic and prebiotic influence beyond the intestinal tract

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12 December 2020

PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells

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12 December 2020

Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes

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12 December 2020

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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12 December 2020

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

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12 December 2020

Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes.

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12 December 2020

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

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12 December 2020

Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase.

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12 December 2020

Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

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12 December 2020

Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets

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12 December 2020

Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake

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12 December 2020

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

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12 December 2020

NASH: Can we iron out the pathogenesis?

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12 December 2020

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

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12 December 2020

The role of cytokines and chemokines in the development of steatohepatitis.

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12 December 2020

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

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12 December 2020

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

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12 December 2020

The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis

1 reference

12 December 2020

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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12 December 2020

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand

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12 December 2020

Cellular sources of collagen and regulation of collagen production in liver

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12 December 2020

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

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12 December 2020

Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization

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12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

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12 December 2020

Nonalcoholic steatohepatitis: definition and pathology

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12 December 2020

Potential Role of Chitotriosidase Gene in Nonalcoholic Fatty Liver Disease Evolution

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12 December 2020

Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences

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12 December 2020

Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion

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12 December 2020

Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes

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12 December 2020

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

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12 December 2020

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition

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12 December 2020

[Role of PPARs in the pathophysiology of nonalcoholoic fatty liver disease]

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12 December 2020

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

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12 December 2020

Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases.

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12 December 2020

Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease

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12 December 2020

Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3′-kinase activity in rats

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12 December 2020

S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis

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12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

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12 December 2020

The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis

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12 December 2020

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function

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12 December 2020

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

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12 December 2020

Glutathione-enhancing agents protect against steatohepatitis in a dietary model

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12 December 2020

Lessons from animal models of NASH

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12 December 2020

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

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12 December 2020

Recent advances in the relationship between obesity, inflammation, and insulin resistance.

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12 December 2020

Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients.

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12 December 2020

Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients

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12 December 2020

Pathophysiology of nonalcoholic steatohepatitis

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12 December 2020

JNK1 but not JNK2 promotes the development of steatohepatitis in mice.

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12 December 2020

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

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12 December 2020

Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

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12 December 2020

Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development

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12 December 2020

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

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12 December 2020

HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity

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12 December 2020

Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions

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12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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12 December 2020

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

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12 December 2020

Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways

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12 December 2020

Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells

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12 December 2020

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity

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12 December 2020

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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12 December 2020

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)

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12 December 2020

Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study.

1 reference

12 December 2020

Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis

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12 December 2020

The subcellular localization of acetyl-CoA carboxylase 2

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12 December 2020

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

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12 December 2020

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

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12 December 2020

Medical treatment of non-alcoholic steatohepatitis

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12 December 2020

Saying "Yes" to obese living liver donors: short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation

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12 December 2020

Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study

1 reference

12 December 2020

Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet.

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12 December 2020

N-acetylcysteine in the treatment of non-alcoholic steatohepatitis

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12 December 2020

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

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12 December 2020

Mitochondrial glutathione: hepatocellular survival-death switch

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12 December 2020

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

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12 December 2020

Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects.

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12 December 2020

The epidemiology of nonalcoholic fatty liver disease in adults

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12 December 2020

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

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12 December 2020

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

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12 December 2020

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

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12 December 2020

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion

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12 December 2020

Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study

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12 December 2020

Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome.

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12 December 2020

Liver fibrosis: a balance of ACEs?

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12 December 2020

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

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12 December 2020

Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

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12 December 2020

Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development

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12 December 2020

Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells

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12 December 2020

Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis

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12 December 2020

Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats.

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12 December 2020

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

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12 December 2020

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

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12 December 2020

Targeting farnesoid X receptor for liver and metabolic disorders.

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12 December 2020

Temporal and spatial assembly of lipid droplet-associated proteins in 3T3-L1 preadipocytes

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12 December 2020

Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.

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12 December 2020

Peroxisomal beta-oxidation and steatohepatitis

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12 December 2020

Cellular mechanisms of insulin resistance

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12 December 2020

Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial

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12 December 2020

10.1007/S00109-009-0464-1

Identifiers

DOI

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release_wfhopl6pazhuthddcw5dttzvvq

20 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/wfhopl6pazhuthddcw5dttzvvq

24 November 2022

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