Developments in obesity genetics in the era of genome-wide association studies (Q37953145)

25 August 2017

Developments in obesity genetics in the era of genome-wide association studies (English)

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genome-wide association study

25 August 2017

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Ruth J F Loos

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25 August 2017

2 November 2011

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Journal of Nutrigenetics and Nutrigenomics

25 August 2017

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4

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222-238

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Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis

25 August 2017

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Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

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The disease burden associated with overweight and obesity

21 January 2018

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Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study

21 January 2018

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Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study.

21 January 2018

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Waist-to-hip ratio and breast cancer mortality

21 January 2018

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Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

21 January 2018

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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

21 January 2018

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Depression and body mass index, a u-shaped association

21 January 2018

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Obesity and mental disorders in the general population: results from the world mental health surveys

21 January 2018

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Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic

21 January 2018

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An Adoption Study of Human Obesity

21 January 2018

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Body weight in the Finnish Twin Cohort

21 January 2018

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The Body-Mass Index of Twins Who Have Been Reared Apart

21 January 2018

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The human obesity gene map: the 2005 update

21 January 2018

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Replication validity of genetic association studies

21 January 2018

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Genome-wide association studies for common diseases and complex traits

21 January 2018

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Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

21 January 2018

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Genomewide scans of complex human diseases: true linkage is hard to find

21 January 2018

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Initial sequencing and analysis of the human genome

21 January 2018

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dbSNP: the NCBI database of genetic variation

21 January 2018

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The International HapMap Project

21 January 2018

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Accessing genetic variation: genotyping single nucleotide polymorphisms

21 January 2018

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Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome

21 January 2018

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Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances

21 January 2018

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Genome-wide association studies: theoretical and practical concerns

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

21 January 2018

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

21 January 2018

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Common genetic variation near MC4R is associated with waist circumference and insulin resistance

21 January 2018

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 January 2018

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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

21 January 2018

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Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

21 January 2018

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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

21 January 2018

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NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

21 January 2018

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

21 January 2018

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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

21 January 2018

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Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

21 January 2018

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Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

21 January 2018

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Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

21 January 2018

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Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population

21 January 2018

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FTO variants are associated with obesity in the Chinese and Malay populations in Singapore

21 January 2018

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Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

21 January 2018

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Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

21 January 2018

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Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study

21 January 2018

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Replication of genetic effects of FTO polymorphisms on BMI in a Korean population

21 January 2018

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Variations in the FTO gene are associated with severe obesity in the Japanese

21 January 2018

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Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population

21 January 2018

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A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population

21 January 2018

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Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.

21 January 2018

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Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population

21 January 2018

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Evaluation of genetic susceptibility loci for obesity in Chinese women

21 January 2018

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Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women

21 January 2018

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Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

21 January 2018

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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

21 January 2018

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Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

21 January 2018

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Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.

21 January 2018

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FTO gene variation and measures of body mass in an African population

21 January 2018

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FTO genetic variation and association with obesity in West Africans and African Americans

21 January 2018

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Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study

21 January 2018

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Fine mapping of the association with obesity at the FTO locus in African-derived populations

21 January 2018

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FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

21 January 2018

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Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort

21 January 2018

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Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs

21 January 2018

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Genome-wide association of anthropometric traits in African- and African-derived populations

21 January 2018

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Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

21 January 2018

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Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.

21 January 2018

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A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

21 January 2018

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Evaluation of A2BP1 as an obesity gene

21 January 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

21 January 2018

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The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI

21 January 2018

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Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth

21 January 2018

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Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study.

21 January 2018

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Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies

21 January 2018

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Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

21 January 2018

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Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals.

21 January 2018

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Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

21 January 2018

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Increasing heritability of BMI and stronger associations with the FTO gene over childhood.

21 January 2018

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Life course variations in the associations between FTO and MC4R gene variants and body size

21 January 2018

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Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

21 January 2018

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Validity of the assessment of dietary intake: problems of misreporting

21 January 2018

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Assessment of physical activity - a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation

21 January 2018

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Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

21 January 2018

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Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

21 January 2018

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Physical activity and the association of common FTO gene variants with body mass index and obesity

21 January 2018

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Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

21 January 2018

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Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women

21 January 2018

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Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.

21 January 2018

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Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study

21 January 2018

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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

21 January 2018

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Overexpression of Fto leads to increased food intake and results in obesity

21 January 2018

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An obesity-associated FTO gene variant and increased energy intake in children

21 January 2018

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Obesity associated genetic variation in FTO is associated with diminished satiety

21 January 2018

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The FTO gene and measured food intake in children

21 January 2018

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Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

21 January 2018

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Variation in the FTO gene influences food intake but not energy expenditure

21 January 2018

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

21 January 2018

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

21 January 2018

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The genetic epidemiology of melanocortin 4 receptor variants.

21 January 2018

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

21 January 2018

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

21 January 2018

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Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.

21 January 2018

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Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure

21 January 2018

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

21 January 2018

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Chromatin and heritability: how epigenetic studies can complement genetic approaches

21 January 2018

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Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity

21 January 2018

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Meta-analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

21 January 2018

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Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

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. . .to a future of genetic medicine

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Identifiers

DOI

10.1159/000332158

1 reference

25 August 2017

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PubMed ID

22056736