Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases (Q37954043)

25 August 2017

Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases (English)

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25 August 2017

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D Randal Mason

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PubMed ID

22067846

25 August 2017

Paul L Beck

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2

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PubMed ID

22067846

25 August 2017

Daniel A Muruve

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3

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25 August 2017

4 November 2011

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Journal of Innate Immunity

25 August 2017

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25 August 2017

4

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25 August 2017

1

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25 August 2017

16-30

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The NLR gene family: a standard nomenclature

25 August 2017

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21 January 2018

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

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Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9.

21 January 2018

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Cryopyrinopathies: update on pathogenesis and treatment.

21 January 2018

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Active caspase-1 is a regulator of unconventional protein secretion

21 January 2018

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Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

21 January 2018

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NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

21 January 2018

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The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock

21 January 2018

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

21 January 2018

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A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

21 January 2018

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Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

21 January 2018

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PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages

21 January 2018

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A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta

21 January 2018

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The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

21 January 2018

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NLRC5 limits the activation of inflammatory pathways

21 January 2018

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NLRX1 is a regulator of mitochondrial antiviral immunity

21 January 2018

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PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.

21 January 2018

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PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion

21 January 2018

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Cutting edge: NLRC5-dependent activation of the inflammasome

21 January 2018

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Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes

21 January 2018

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NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

21 January 2018

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Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes

21 January 2018

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NLRP4 negatively regulates autophagic processes through an association with beclin1.

21 January 2018

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Mater, a maternal effect gene required for early embryonic development in mice

21 January 2018

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Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans

21 January 2018

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Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure

21 January 2018

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

21 January 2018

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Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

21 January 2018

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A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses

21 January 2018

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Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

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A pilot study of IL-1 inhibition by anakinra in acute gout

21 January 2018

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SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways

21 January 2018

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Expression and function of the NALP3 inflammasome in rheumatoid synovium.

21 January 2018

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Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium

21 January 2018

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

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Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

21 January 2018

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Inhibition of human DNA polymerase beta activity by the anticancer prodrug Cloretazine

21 January 2018

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

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Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease

21 January 2018

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Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis.

21 January 2018

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NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses

21 January 2018

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Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis

21 January 2018

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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

21 January 2018

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Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy

21 January 2018

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Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains

21 January 2018

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NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

21 January 2018

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Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP

21 January 2018

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Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

21 January 2018

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The immune system in atherosclerosis

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response.

21 January 2018

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The inflammasome NLRs in immunity, inflammation, and associated diseases

21 January 2018

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Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis

21 January 2018

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An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

21 January 2018

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

21 January 2018

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The Nalp3 inflammasome is essential for the development of silicosis

21 January 2018

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Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β

21 January 2018

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Intravascular danger signals guide neutrophils to sites of sterile inflammation

21 January 2018

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Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

21 January 2018

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Inflammasome-mediated regulation of hepatic stellate cells

21 January 2018

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

21 January 2018

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

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Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

21 January 2018

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Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

21 January 2018

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The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

21 January 2018

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Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors

21 January 2018

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NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

21 January 2018

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The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

21 January 2018

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Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure

21 January 2018

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

21 January 2018

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An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury

21 January 2018

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NALP expression in Paneth cells provides a novel track in IBD signaling.

21 January 2018

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

21 January 2018

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NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

21 January 2018

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

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A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

21 January 2018

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NALP1 in vitiligo-associated multiple autoimmune disease

21 January 2018

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

21 January 2018

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Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity

21 January 2018

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NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis

21 January 2018

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Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

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Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000334247

1 reference

25 August 2017

1 reference

PubMed ID

22067846