Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target (Q37959134)

25 August 2017

Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target (English)

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25 August 2017

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Emmanuel Pinteaux

2

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Stuart M. Allan

object named as

Stuart M Allan

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4

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Nancy Rothwell

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3

object named as

Nancy J Rothwell

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25 August 2017

Adam Denes

1

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25 August 2017

18 November 2011

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25 August 2017

Cerebrovascular Diseases

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25 August 2017

32

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25 August 2017

6

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25 August 2017

517-527

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

25 August 2017

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Update of the stroke therapy academic industry roundtable preclinical recommendations

21 January 2018

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Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke

21 January 2018

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Interleukin-1 receptor antagonist in animal models of stroke: a fair summing up?

21 January 2018

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Interleukin-1 stimulation of astroglial proliferation after brain injury.

21 January 2018

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Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production.

21 January 2018

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Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor

21 January 2018

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Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

21 January 2018

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Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model

21 January 2018

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Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice.

21 January 2018

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A molecular platform in neurons regulates inflammation after spinal cord injury

21 January 2018

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Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury

21 January 2018

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Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.

21 January 2018

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Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis

21 January 2018

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Association of interleukin-1 alpha gene polymorphism with cerebral infarction

21 January 2018

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Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease.

21 January 2018

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Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation

21 January 2018

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Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke

21 January 2018

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Interleukin-1 receptor antagonist gene polymorphism and susceptibility to ischemic stroke.

21 January 2018

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Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation.

21 January 2018

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Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells

21 January 2018

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Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

21 January 2018

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Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

21 January 2018

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The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex

21 January 2018

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Interleukin-1 receptor accessory protein transcripts in the brain and spleen: kinetics after peripheral administration of bacterial lipopolysaccharide in mice.

21 January 2018

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A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1

21 January 2018

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IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons

21 January 2018

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Ceramide mediates the rapid phase of febrile response to IL-1beta

21 January 2018

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Interleukin 1beta modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance.

21 January 2018

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Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity.

21 January 2018

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Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

21 January 2018

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Interleukin-1beta: a bridge between inflammation and excitotoxicity?

21 January 2018

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IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice

21 January 2018

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Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion.

21 January 2018

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Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity

21 January 2018

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Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways

21 January 2018

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Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration.

21 January 2018

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Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

21 January 2018

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

21 January 2018

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Blocking interleukin-1β in acute and chronic autoinflammatory diseases

21 January 2018

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Type 2 diabetes as an inflammatory disease

21 January 2018

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Blocking IL-1 in systemic inflammation

21 January 2018

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Effects of Interleukin-1 on Blood Pressure, Sympathetic Nerve Activity, and Pituitary Endocrine Functions in Anesthetized Rats

21 January 2018

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The effects of interleukin-1β on the activity of adrenal, splenic and renal sympathetic nerves in the rat

21 January 2018

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Systemic infection, inflammation and acute ischemic stroke.

21 January 2018

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Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation.

21 January 2018

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

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Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding

21 January 2018

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Brain inflammation is induced by co-morbidities and risk factors for stroke

21 January 2018

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Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms

21 January 2018

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Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.

21 January 2018

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(Peri)vascular production and action of pro-inflammatory cytokines in brain pathology

21 January 2018

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Platelet interleukin-1alpha drives cerebrovascular inflammation.

21 January 2018

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Platelet-leukocyte interaction and platelet activation in acute stroke with and without preceding infection.

21 January 2018

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Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees

21 January 2018

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Fibrinolytic response to tumor necrosis factor in healthy subjects

21 January 2018

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Role of inflammatory mediators in thrombogenesis

21 January 2018

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Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice

21 January 2018

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Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly

21 January 2018

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Influenza virus infection aggravates stroke outcome

21 January 2018

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Imbalanced secretion of IL-1beta and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

21 January 2018

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Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.

21 January 2018

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The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

21 January 2018

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Host adaptive immunity deficiency in severe pandemic influenza.

21 January 2018

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The role of the adrenals in the acute phase response to interleukin-1 and tumor necrosis factor-alpha.

21 January 2018

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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

21 January 2018

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Averting inflammation by targeting the cytokine environment

21 January 2018

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Interleukin-1β protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo

21 January 2018

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Structural insights into the assembly and activation of IL-1β with its receptors

21 January 2018

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Pooling of animal experimental data reveals influence of study design and publication bias

21 January 2018

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Interleukin-1 and neuronal injury

21 January 2018

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Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential

21 January 2018

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

21 January 2018

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Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.

21 January 2018

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Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

21 January 2018

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Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

21 January 2018

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Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

21 January 2018

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IL-1 receptor antagonist as an aerosol in inflammation

21 January 2018

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A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000332205

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release_f2wmfpipjbg5xptfailkp2wxye

25 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/f2wmfpipjbg5xptfailkp2wxye

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22104408

1 reference

PubMed ID

22104408