Epigenetic targets in human neoplasms (Q37961723)

26 August 2017

title

Epigenetic targets in human neoplasms (English)

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26 August 2017

Tamer E Fandy

1

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26 August 2017

Steven D Gore

series ordinal

2

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26 August 2017

publication date

1 April 2010

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26 August 2017

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26 August 2017

volume

2

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26 August 2017

issue

2

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26 August 2017

page(s)

221-232

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Covalent modifications of histones during development and disease pathogenesis

26 August 2017

cites work

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The epigenomics of cancer

21 January 2018

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Worms gang up on bacteria

21 January 2018

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Epigenetic inheritance during the cell cycle

21 January 2018

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Nucleosome destabilization in the epigenetic regulation of gene expression

21 January 2018

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Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes

21 January 2018

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Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex

21 January 2018

1 reference

Epigenetic connections between autoimmune disorders and haematological malignancies

21 January 2018

1 reference

A high-resolution radiation hybrid map of the human genome draft sequence.

21 January 2018

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Moving AHEAD with an international human epigenome project.

21 January 2018

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Epigenomics: a roadmap, but to where?

21 January 2018

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Perceptions of epigenetics

21 January 2018

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CBP/p300-mediated acetylation of histone H3 on lysine 56

21 January 2018

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SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

21 January 2018

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

21 January 2018

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Histone ubiquitination: triggering gene activity

21 January 2018

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Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation

21 January 2018

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

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Histone deacetylase inhibitors: Potential in cancer therapy

21 January 2018

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Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.

21 January 2018

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Requirement of histone deacetylase activity for signaling by STAT1.

21 January 2018

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Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21.

21 January 2018

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The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

21 January 2018

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Acetylation in histone H3 globular domain regulates gene expression in yeast.

21 January 2018

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Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation.

21 January 2018

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Phosphorylation of histone H3 Thr-45 is linked to apoptosis

21 January 2018

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies

21 January 2018

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Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma

21 January 2018

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Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior.

21 January 2018

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Global levels of histone modifications predict prognosis in different cancers

21 January 2018

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A novel method to detect functional microRNA targets

21 January 2018

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The functions of animal microRNAs

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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Switching from repression to activation: microRNAs can up-regulate translation

21 January 2018

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c-Myc-regulated microRNAs modulate E2F1 expression

21 January 2018

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Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

21 January 2018

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A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk

21 January 2018

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Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes

21 January 2018

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MicroRNA silencing in primates: towards development of novel therapeutics

21 January 2018

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Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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Circulating microRNAs as stable blood-based markers for cancer detection

21 January 2018

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The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform

21 January 2018

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Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies

21 January 2018

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Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols

21 January 2018

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Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

21 January 2018

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SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes

21 January 2018

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Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

21 January 2018

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Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

21 January 2018

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Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse.

21 January 2018

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Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice

21 January 2018

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Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

21 January 2018

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Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model.

21 January 2018

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The vegetarian lifestyle and DNA methylation

21 January 2018

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Trapped in action: direct visualization of DNA methyltransferase activity in living cells.

21 January 2018

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A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly

21 January 2018

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Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

21 January 2018

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A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia

21 January 2018

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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

21 January 2018

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Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

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AML1 mutations induced MDS and MDS/AML in a mouse BMT model

21 January 2018

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Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.

21 January 2018

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Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome.

21 January 2018

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NUP98-HOX translocations lead to myelodysplastic syndrome in mice and men

21 January 2018

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Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

21 January 2018

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Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

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Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

21 January 2018

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Preferential response of cancer cells to zebularine.

21 January 2018

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Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

21 January 2018

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Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine

21 January 2018

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Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells

21 January 2018

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Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

21 January 2018

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Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines

21 January 2018

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

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Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

21 January 2018

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

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The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

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The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

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Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

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Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

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Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

21 January 2018

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Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

21 January 2018

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Oncomirs - microRNAs with a role in cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.10.1

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26 August 2017

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