miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs (Q37962609)

26 August 2017

title

miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs (English)

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26 August 2017

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Alex Manicardi

9

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Ilaria Lampronti

Ilaria Lampronti

4

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Alessia Finotti

Alessia Finotti

5

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Roberto Corradini

Roberto Corradini

11

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Nicoletta Bianchi

Nicoletta Bianchi

6

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Monica Borgatti

Monica Borgatti

3

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Roberto Gambari

Roberto Gambari

12

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Eleonora Brognara

Eleonora Brognara

2

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Enrica Fabbri

Enrica Fabbri

1

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Rosangela Marchelli

10

Rosangela Marchelli

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26 August 2017

7

Stefano Sforza

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26 August 2017

8

Tullia Tedeschi

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26 August 2017

publication date

1 December 2011

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26 August 2017

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26 August 2017

volume

3

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26 August 2017

issue

6

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26 August 2017

page(s)

733-745

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Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

26 August 2017

cites work

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Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion

21 January 2018

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Peptide-nucleic acids (PNAs): a tool for the development of gene expression modifiers

21 January 2018

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The peptide nucleic acids (PNAs): a new generation of probes for genetic and cytogenetic analyses

21 January 2018

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Targeting double stranded DNA with peptide nucleic acid (PNA).

21 January 2018

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Progress in developing PNA as a gene-targeted drug

21 January 2018

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Recent advances in the development of peptide nucleic acid as a gene-targeted drug

21 January 2018

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Antisense properties of peptide nucleic acids

21 January 2018

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Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

21 January 2018

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A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides.

21 January 2018

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Post-transcriptional gene silencing by siRNAs and miRNAs

21 January 2018

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MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

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miRBase: integrating microRNA annotation and deep-sequencing data

21 January 2018

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Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kappaB transcription factors

21 January 2018

1 reference

PNA-nucleic acid complexes. Structure, stability and dynamics

21 January 2018

1 reference

Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells

21 January 2018

1 reference

Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa

21 January 2018

1 reference

Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments

21 January 2018

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Peptide nucleic acids (PNAs) antisense effect to bacterial growth and their application potentiality in biotechnology

21 January 2018

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Prospects for antisense peptide nucleic acid (PNA) therapies for HIV

21 January 2018

1 reference

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

21 January 2018

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Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.

21 January 2018

1 reference

Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

21 January 2018

1 reference

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters

21 January 2018

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Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immunodeficiency virus type 1 promoter.

21 January 2018

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Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-kappaB binding sites.

21 January 2018

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Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites

21 January 2018

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Transcription factor decoy (TFD) in breast cancer research and treatment

21 January 2018

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Biological activity and delivery of peptide nucleic acids (PNA)-DNA chimeras for transcription factor decoy (TFD) pharmacotherapy

21 January 2018

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Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression

21 January 2018

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Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites

21 January 2018

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Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles

21 January 2018

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Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity

21 January 2018

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Liposomes as carriers for DNA-PNA hybrids

21 January 2018

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Nucleobase modifications in peptide nucleic acids

21 January 2018

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High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers

21 January 2018

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Affinity and selectivity of C2- and C5-substituted "chiral-box" PNA in solution and on microarrays

21 January 2018

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Cellular Delivery and Antisense Effects of Peptide Nucleic Acid Conjugated to Polyethyleneimine via Disulfide Linkers

21 January 2018

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gamma-Hydroxymethyl PNAs: Synthesis, interaction with DNA and inhibition of protein/DNA interactions

21 January 2018

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Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).

21 January 2018

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Efficiency of cellular delivery of antisense peptide nucleic acid by electroporation depends on charge and electroporation geometry

21 January 2018

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Enhanced cellular delivery of cell-penetrating peptide-peptide nucleic acid conjugates by photochemical internalization

21 January 2018

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Silence from within: endogenous siRNAs and miRNAs.

21 January 2018

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Cell cycle regulation by MicroRNAs in embryonic stem cells

21 January 2018

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MicroRNA functions in animal development and human disease

21 January 2018

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UCbase & miRfunc: a database of ultraconserved sequences and microRNA function

21 January 2018

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Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

21 January 2018

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MicroRNAs as therapeutic targets

21 January 2018

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Cancer therapy via modulation of micro RNA levels: a promising future

21 January 2018

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MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection.

21 January 2018

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LNA-mediated microRNA silencing in non-human primates

21 January 2018

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

21 January 2018

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Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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RNA interference-based therapeutics: new strategies to fight infectious disease

21 January 2018

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Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes

21 January 2018

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

21 January 2018

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Specificity, duplex degradation and subcellular localization of antagomirs

21 January 2018

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LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

21 January 2018

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Improved targeting of miRNA with antisense oligonucleotides

21 January 2018

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miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates

21 January 2018

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mRNA isoform diversity can obscure detection of miRNA-mediated control of translation

21 January 2018

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Coding region: the neglected post-transcriptional code

21 January 2018

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Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents

21 January 2018

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Synthesis and in vitro evaluation of PNA-peptide-DETA conjugates as potential cell penetrating artificial ribonucleases.

21 January 2018

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Intravesical antisense therapy for cystitis using TAT-peptide nucleic acid conjugates

21 January 2018

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Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid

21 January 2018

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"Translocatory proteins" and "protein transduction domains": a critical analysis of their biological effects and the underlying mechanisms

21 January 2018

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A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells

21 January 2018

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Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake

21 January 2018

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Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

21 January 2018

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An efficient biodelivery system for antisense polyamide nucleic acid (PNA).

21 January 2018

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Photochemical internalization: a new tool for drug delivery.

21 January 2018

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Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption

21 January 2018

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Multiplexed detection and label-free quantitation of microRNAs using arrays of silicon photonic microring resonators

21 January 2018

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Impact of microRNAs for pathogenesis and treatment of hepatitis C virus infection

21 January 2018

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Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma

21 January 2018

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Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C.

21 January 2018

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

21 January 2018

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miR-155: on the crosstalk between inflammation and cancer

21 January 2018

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MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer

21 January 2018

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MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene

21 January 2018

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Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression

21 January 2018

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Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth

21 January 2018

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Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element

21 January 2018

1 reference

Peptide nucleic acids with a structurally biased backbone. Updated review and emerging challenges.

21 January 2018

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Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility

21 January 2018

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Peptide nucleic acid containing a meta-substituted phenylpyrrolocytosine exhibits a fluorescence response and increased binding affinity toward RNA.

21 January 2018

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Cyclohexanyl peptide nucleic acids (chPNAs) for preferential RNA binding: effective tuning of dihedral angle beta in PNAs for DNA/RNA discrimination

21 January 2018

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Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences

21 January 2018

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Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

21 January 2018

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Immunological response to peptide nucleic acid and its peptide conjugate targeted to transactivation response (TAR) region of HIV-1 RNA genome

21 January 2018

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Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.11.90

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26 August 2017

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