Improved targeting of miRNA with antisense oligonucleotides (Q24547511)

1

0 references

Bridget Lollo

2

0 references

Susan Freier

3

0 references

Christine Esau

describes a project that uses

4

0 references

language of work or name

English

0 references

publication date

2006

0 references

published in

Nucleic Acids Research

0 references

volume

34

0 references

issue

8

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page(s)

2294-304

0 references

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1459537/fullTextXML

inferred from PubMed Central ID database lookup

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miR-15 and miR-16 induce apoptosis by targeting BCL2

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The influence of locked nucleic acid residues on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexes

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

24 March 2017

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Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

24 March 2017

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MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

24 March 2017

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

24 March 2017

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Sequence-specific inhibition of small RNA function

24 March 2017

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

24 March 2017

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

24 March 2017

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

24 March 2017

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The nuclear RNase III Drosha initiates microRNA processing

24 March 2017

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

24 March 2017

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Silencing of microRNAs in vivo with 'antagomirs'

24 March 2017

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

24 March 2017

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c-Myc-regulated microRNAs modulate E2F1 expression

24 March 2017

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MicroRNA expression profiles classify human cancers

24 March 2017

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RAS is regulated by the let-7 microRNA family

7 April 2017

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

24 March 2017

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

7 April 2017

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The functions of animal microRNAs

24 March 2017

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MicroRNAs: small RNAs with a big role in gene regulation

24 March 2017

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MicroRNAs: genomics, biogenesis, mechanism, and function

24 March 2017

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MicroRNAs modulate hematopoietic lineage differentiation

24 March 2017

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Nuclear export of microRNA precursors

24 March 2017

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

24 March 2017

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

24 March 2017

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Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

24 March 2017

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Regulating gene expression through RNA nuclear retention

24 March 2017

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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

24 March 2017

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Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development

24 March 2017

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Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation

24 March 2017

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A pancreatic islet-specific microRNA regulates insulin secretion

24 March 2017

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MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

24 March 2017

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

24 March 2017

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Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

7 April 2017

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Effective targeted gene 'knockdown' in zebrafish

7 April 2017

1 reference

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A brain-specific microRNA regulates dendritic spine development

7 April 2017

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A cellular microRNA mediates antiviral defense in human cells

7 April 2017

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MicroRNA-143 regulates adipocyte differentiation

7 April 2017

1 reference

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Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

27 September 2017

MicroRNAs as oncogenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Slicer function of Drosophila Argonautes and its involvement in RISC formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

microPrimer: the biogenesis and function of microRNA.

27 September 2017

1 reference

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Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

RNA interference: from gene silencing to gene-specific therapeutics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

A functionally improved locked nucleic acid antisense oligonucleotide inhibits Bcl-2 and Bcl-xL expression and facilitates tumor cell apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antisense and RNA interference approaches to target validation in pain research.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Functional genomics to new drug targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Oligonucleotide therapeutics: 25 years agrowing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antisense oligonucleotide-based therapeutics for cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

27 September 2017

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27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Functional genomics and target validation approaches using antisense oligonucleotide technology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antisense oligonucleotides for target validation in the CNS.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Effects of RNA secondary structure on cellular antisense activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Physicochemical properties of phosphorothioate oligodeoxynucleotides

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Highly efficient chemical synthesis of 2'-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Absorbance melting curves of RNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459537

Nucleotides LXIV[1]: synthesis hydridization and enzymatic degradation studies of 2'-O-methyloligoribonucleotides and 2'-O-methyl/deoxy gapmers

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16690972

12 December 2020

inferred from PubMed ID database lookup

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16690972

12 December 2020

inferred from PubMed ID database lookup

Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16690972

12 December 2020