Epigenetic cancer therapy: rationales, targets and drugs (Q37969665)

26 August 2017

Epigenetic cancer therapy: rationales, targets and drugs (English)

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26 August 2017

M Rius

1

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PubMed ID

22179827

26 August 2017

F Lyko

series ordinal

2

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PubMed ID

22179827

26 August 2017

language of work or name

English

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publication date

19 December 2011

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26 August 2017

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26 August 2017

31

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26 August 2017

39

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26 August 2017

4257-4265

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https://scigraph.springernature.com/pub.10.1038/onc.2011.601

26 August 2017

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cites work

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

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Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia

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Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

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DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

21 January 2018

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Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy

21 January 2018

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

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Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition

21 January 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

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S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

21 January 2018

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Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

21 January 2018

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Transport of glutathione and glutathione conjugates by MRP1.

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

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Human nucleoside transporters: biomarkers for response to nucleoside drugs.

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Epigenetics in human disease and prospects for epigenetic therapy

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DNA methylation in cancer: too much, but also too little

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

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Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis

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Induction of Tumors in Mice by Genomic Hypomethylation

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Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines

21 January 2018

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Increased methylation variation in epigenetic domains across cancer types

21 January 2018

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A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

21 January 2018

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Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.

21 January 2018

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Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance

21 January 2018

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Transport of nucleoside analogs across the plasma membrane: a clue to understanding drug-induced cytotoxicity

21 January 2018

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Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate

21 January 2018

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Targeting DNA methylation

21 January 2018

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

21 January 2018

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The epigenomics of cancer

21 January 2018

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Cellular differentiation, cytidine analogs and DNA methylation

21 January 2018

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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

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Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

21 January 2018

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Suppression of intestinal neoplasia by DNA hypomethylation.

21 January 2018

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The Role of ABC Transporters in Clinical Practice

21 January 2018

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Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

21 January 2018

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As we bring demethylating drugs to the clinic, we better know the DICE being cast.

21 January 2018

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Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism

21 January 2018

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Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

21 January 2018

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Genetics and epigenetics: stability and plasticity during cellular differentiation

21 January 2018

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation?

21 January 2018

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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

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Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

Cell entry and export of nucleoside analogues

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

21 January 2018

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Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.601

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Is there a code embedded in proteins that is based on post-translational modifications?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.601

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.601

1 reference

26 August 2017

1 reference

PubMed ID

22179827