The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update (Q37970585)

26 August 2017

The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update (English)

1 reference

26 August 2017

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Hanrui Zhang

1

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PMCID

5512574

26 August 2017

Kevin C Dellsperger

series ordinal

2

1 reference

PMCID

5512574

26 August 2017

Cuihua Zhang

series ordinal

3

1 reference

26 August 2017

22 December 2011

1 reference

Basic Research in Cardiology

26 August 2017

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26 August 2017

107

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26 August 2017

1

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26 August 2017

237

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https://scigraph.springernature.com/pub.10.1007/s00395-011-0237-1

26 August 2017

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Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness

6 September 2017

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Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice

6 September 2017

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Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats

6 September 2017

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6 September 2017

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6 September 2017

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Endothelin-1 and diabetic complications: focus on the vasculature

6 September 2017

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6 September 2017

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Free fatty acids induce insulin resistance in both cardiac and skeletal muscle microvasculature in humans

6 September 2017

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Endothelial dysfunction as a potential contributor in diabetic nephropathy

6 September 2017

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Is oxidative stress a therapeutic target in cardiovascular disease?

6 September 2017

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Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice

6 September 2017

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Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

6 September 2017

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Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes

6 September 2017

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Endothelial glycocalyx and coronary vascular permeability: the fringe benefit

6 September 2017

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COX-mediated endothelium-dependent contractions: from the past to recent discoveries

6 September 2017

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Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

6 September 2017

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Activation of protein kinase C isoforms and its impact on diabetic complications

6 September 2017

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Adipose "talks" to distant organs to regulate insulin sensitivity and vascular function

6 September 2017

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Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications

6 September 2017

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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

6 September 2017

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Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects

6 September 2017

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Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 Diabetes: Evidence of an Adipose-Vascular Loop

6 September 2017

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Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

6 September 2017

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Glucose control and cardiovascular disease: is it important? No.

6 September 2017

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Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands

6 September 2017

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Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice

6 September 2017

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6 September 2017

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Obesity induced-insulin resistance causes endothelial dysfunction without reducing the vascular response to hindlimb ischemia.

6 September 2017

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Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress

6 September 2017

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The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

6 September 2017

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Endothelial dysfunction and vascular disease

6 September 2017

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Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets.

6 September 2017

1 reference

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Does reversal of oxidative stress and inflammation provide vascular protection?

6 September 2017

1 reference

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Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes

6 September 2017

1 reference

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Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Endothelium-dependent contractions: when a good guy turns bad!

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Role of EDHF in type 2 diabetes-induced endothelial dysfunction

6 September 2017

1 reference

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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

6 September 2017

1 reference

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Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.

6 September 2017

1 reference

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Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase

6 September 2017

1 reference

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AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Inflammatory mechanisms in the regulation of insulin resistance

6 September 2017

1 reference

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The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient

6 September 2017

1 reference

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Metabolic consequences of hyperglycemia and insulin resistance

6 September 2017

1 reference

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p38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappaB degradation in human coronary artery endothelial cells

6 September 2017

1 reference

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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

6 September 2017

1 reference

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Vascular complications in diabetes mellitus: the role of endothelial dysfunction

6 September 2017

1 reference

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Inflammation, stress, and diabetes

6 September 2017

1 reference

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

6 September 2017

1 reference

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Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability

6 September 2017

1 reference

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

6 September 2017

1 reference

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Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

6 September 2017

1 reference

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Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury

6 September 2017

1 reference

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Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

14 September 2017

1 reference

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Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells

14 September 2017

1 reference

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Elevated concentrations of nonesterified fatty acids increase monocyte expression of CD11b and adhesion to endothelial cells

14 September 2017

1 reference

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Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity

14 September 2017

1 reference

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Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction

23 June 2018

1 reference

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Endothelium-derived hyperpolarizing factor and diabetes

23 June 2018

1 reference

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Enhanced cyclooxygenase 2-mediated vasorelaxation in coronary arteries from insulin-resistant obese Zucker rats

23 June 2018

1 reference

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CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function

23 June 2018

1 reference

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Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats

23 June 2018

1 reference

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Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Mechanisms of vascular insulin resistance: a substitute Akt?

23 June 2018

1 reference

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Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells

23 June 2018

1 reference

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Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone.

23 June 2018

1 reference

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C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide

1 September 2018

1 reference

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Glycated albumin, a precursor of advanced glycation end-products, up-regulates NADPH oxidase and enhances oxidative stress in human endothelial cells: molecular correlate of diabetic vasculopathy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Oxidative stress and apoptosis of human brain microvascular endothelial cells induced by free fatty acids.

1 September 2018

1 reference

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High FFA-induced proliferation and apoptosis in human umbilical vein endothelial cell partly through Wnt/beta-catenin signal pathway.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Role of oxidative stress in elevated blood pressure induced by high free fatty acids

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Role of protein kinase C in the expression of endothelin converting enzyme-1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Effect of endothelium-specific insulin resistance on endothelial function in vivo

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells

1 September 2018

1 reference

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Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice.

1 September 2018

1 reference

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Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation.

1 September 2018

1 reference

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Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta

1 September 2018

1 reference

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Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

1 September 2018

1 reference

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Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.

1 September 2018

1 reference

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Inhibition of the renin-angiotensin system prevents free fatty acid-induced acute endothelial dysfunction in humans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5512574

Direct apoptotic effects of free fatty acids on human endothelial cells

3 December 2018

1 reference

12 December 2020

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

1 reference

12 December 2020

Regulation of vascular guanylyl cyclase by endothelial nitric oxide-dependent posttranslational modification

1 reference

12 December 2020

Obesity and inflammatory vasculopathy: a surgical solution as ultima ratio?

1 reference

12 December 2020

Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia. Role of oxidative stress, reduced NO, and enhanced PGH(2)/TXA(2) mediation

1 reference

12 December 2020

Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells

1 reference

12 December 2020

Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase

1 reference

12 December 2020

Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis

1 reference

12 December 2020

Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats

1 reference

12 December 2020

Rosiglitazone prevents free fatty acid-induced vascular endothelial dysfunction

1 reference

12 December 2020

10.1007/S00395-011-0237-1

Identifiers

DOI

1 reference

26 August 2017

1 reference

26 August 2017

1 reference

PMCID

5512574