Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown (Q37981274)

26 August 2017

Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown (English)

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G protein-coupled receptor

26 August 2017

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Anastasios Lymperopoulos

series ordinal

1

object named as

Anastasios Lymperopoulos

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Ashley Bathgate

series ordinal

2

object named as

Ashley Bathgate

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publication date

1 February 2012

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26 August 2017

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26 August 2017

13

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26 August 2017

323-341

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26 August 2017

3

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Initial sequencing and analysis of the human genome

26 August 2017

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https://api.crossref.org/works/10.2217%2FPGS.11.178

The Sequence of the Human Genome

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.11.178

Beyond desensitization: physiological relevance of arrestin-dependent signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Teaching old receptors new tricks: biasing seven-transmembrane receptors

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.11.178

Historical review: a brief history and personal retrospective of seven-transmembrane receptors

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.11.178

Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Adrenergic signaling polymorphisms and their impact on cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Drug receptor/effector polymorphisms and pharmacogenetics: current status and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Genetic variations in human G protein-coupled receptors: implications for drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

GRK mythology: G-protein receptor kinases in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Mutant G-protein-coupled receptors as a cause of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Targeting G protein-coupled receptor kinases to their receptor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Seven-transmembrane-spanning receptors and heart function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.11.178

Beta-arrestins and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta 1-adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A polymorphism-specific "memory" mechanism in the β(2)-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Comparison of the beneficial effect of beta-blockers on mortality in patients with ischaemic or non-ischaemic systolic heart failure: a meta-analysis of randomised controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

The role of race in heart failure therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Clinical and genetic modifiers of long-term survival in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Neurohumoral features of myocardial stunning due to sudden emotional stress

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

G protein-coupled receptors. II. Mechanism of agonist activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Structural insights into adrenergic receptor function and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Ocular findings in a family with autosomal dominant retinitis pigmentosa and a frameshift mutation altering the carboxyl terminal sequence of rhodopsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Dominant retinitis pigmentosa associated with two rhodopsin gene mutations. Leu-40-Arg and an insertion disrupting the 5'-splice junction of exon 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

The sequence of human retinal S-antigen reveals similarities with alpha-transducin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Novel mutations in the arrestin gene and associated clinical features in Japanese patients with Oguchi's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

G protein coupled receptor kinases as therapeutic targets in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

GRK2 as a novel gene therapy target in heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

G-protein-coupled receptor kinase activity is increased in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Effects of gender and genotype on the phenotypic expression of nonmodulating essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Regulation of G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Association analysis of GRK3 gene promoter variants in cocaine abuse.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Beta-arrestin signaling and regulation of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

Physical Activity, Diet, and Incident Diabetes in Relation to an ADRA2B Polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.11.178

21 January 2018

Identifiers

DOI

10.2217/PGS.11.178

1 reference

26 August 2017

1 reference

PubMed ID

22304582