Histamine H4 receptor ligands and their potential therapeutic applications: an update (Q37990004)

26 August 2017

Histamine H4 receptor ligands and their potential therapeutic applications: an update (English)

1 reference

26 August 2017

Róbert Kiss

1

1 reference

PubMed ID

22385042

26 August 2017

György M Keserű

series ordinal

2

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PubMed ID

22385042

26 August 2017

language of work or name

English

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publication date

3 March 2012

1 reference

Expert Opinion on Therapeutic Patents

26 August 2017

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26 August 2017

22

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26 August 2017

3

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26 August 2017

205-221

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Histamine H4 receptor ligands and their potential therapeutic applications

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The role of histamine H4 receptor in immune and inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Azines as histamine H4 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Targeting the histamine H4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Targeted treatment of pruritus: a look into the future

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Pathophysiology of itch and new treatments

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Chronic pruritus--pathogenesis, clinical aspects and treatment

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1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The role of the histamine H4 receptor in atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Effect of histamine H4 receptor antagonist on allergic rhinitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Role of histamine H(4) receptor in allergic conjunctivitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Immunological identification of the mouse H4 histamine receptor on spinal cord motor neurons using a novel anti-mouse H4R antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Role of H4 receptor in histamine-mediated responses in human melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

N (α)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Synthesis and histamine H(3) and H(4) receptor activity of conformationally restricted cyanoguanidines related to UR-PI376.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

The histamine H₄ receptor: targeting inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4Receptor Affinity and Subtly Govern H4/H3Subtype Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Triamino pyrimidines and pyridines as histamine H4 receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure–activity relationship (SAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.665447

10.1517/13543776.2012.665447

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22385042