Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae (Q37990942)

26 August 2017

Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae (English)

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26 August 2017

Streptococcus pneumoniae

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Regine Hakenbeck

1

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26 August 2017

Reinhold Brückner

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2

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26 August 2017

Dalia Denapaite

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3

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26 August 2017

Patrick Maurer

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4

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26 August 2017

1 March 2012

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26 August 2017

16

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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26 August 2017

7

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26 August 2017

395-410

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26 August 2017

3

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Emergence of Multiply Resistant Pneumococci

26 August 2017

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Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and beta-lactam consumption in Spain (1979-1997).

21 January 2018

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Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States

21 January 2018

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Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility

21 January 2018

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In vitro antimicrobial susceptibility of viridans streptococci isolated from blood cultures

21 January 2018

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Bacteremia due to viridans streptococci that are highly resistant to penicillin: increase among neutropenic patients with cancer.

21 January 2018

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Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae

21 January 2018

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Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae

21 January 2018

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Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms

21 January 2018

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Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network

21 January 2018

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Rapid pneumococcal evolution in response to clinical interventions

21 January 2018

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Penicillin-resistant Streptococcus pneumoniae in Germany: genetic relationship to clones from other European countries.

21 January 2018

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Antimicrobial resistance among isolates causing invasive pneumococcal disease before and after licensure of heptavalent conjugate pneumococcal vaccine

21 January 2018

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Heteroresistance to penicillin in Streptococcus pneumoniae

21 January 2018

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Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent

21 January 2018

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The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

21 January 2018

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Positive selection in penicillin-binding proteins 1a, 2b, and 2x from Streptococcus pneumoniae and its correlation with amoxicillin resistance development

21 January 2018

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Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins

21 January 2018

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Antigenic Variation of Penicillin-Binding Proteins from Penicillin-Resistant Clinical Strains of Streptococcus pneumoniae

21 January 2018

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Penicillin-binding proteins and beta-lactam resistance

21 January 2018

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The glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae catalyzes the polymerization of murein glycan chains

21 January 2018

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Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae

21 January 2018

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Unusual septum formation in Streptococcus pneumoniae mutants with an alteration in the D,D-carboxypeptidase penicillin-binding protein 3.

21 January 2018

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Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin‐binding proteins during the cell cycle

21 January 2018

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The different shapes of cocci

21 January 2018

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The D,D-carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae

21 January 2018

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Bridging cell wall biosynthesis and bacterial morphogenesis.

21 January 2018

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Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae

21 January 2018

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Very low cefotaxime concentrations select for hypermutable Streptococcus pneumoniae populations

21 January 2018

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Penicillin tolerance in multiply drug-resistant natural isolates of Streptococcus pneumoniae.

21 January 2018

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A global gene pool for high-level cephalosporin resistance in commensal Streptococcus species and Streptococcus pneumoniae

21 January 2018

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Complex relationship between acquisition of beta-lactam resistance and loss of virulence in Streptococcus pneumoniae

21 January 2018

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Compensatory evolution of pbp mutations restores the fitness cost imposed by β-lactam resistance in Streptococcus pneumoniae

21 January 2018

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An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.

21 January 2018

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Common alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward beta-lactams: structural insights

21 January 2018

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Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae

21 January 2018

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Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis

21 January 2018

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Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene.

21 January 2018

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Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.

21 January 2018

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Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S. pneumoniae.

21 January 2018

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X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme

21 January 2018

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Penicillin-binding protein 2x of Streptococcus pneumoniae: three new mutational pathways for remodelling an essential enzyme into a resistance determinant

21 January 2018

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Penicillin-binding proteins in beta-lactam-resistant laboratory mutants of Streptococcus pneumoniae.

21 January 2018

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Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins

21 January 2018

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Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan

21 January 2018

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Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -inte

21 January 2018

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Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics.

21 January 2018

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The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance

21 January 2018

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Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria

21 January 2018

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Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations

21 January 2018

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The structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strains

21 January 2018

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A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics

21 January 2018

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Pneumococcal beta-lactam resistance due to a conformational change in penicillin-binding protein 2x.

21 January 2018

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Amino acid mutations essential to production of an altered PBP 2X conferring high-level beta-lactam resistance in a clinical isolate of Streptococcus pneumoniae

21 January 2018

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Kinetics of beta-lactam interactions with penicillin-susceptible and -resistant penicillin-binding protein 2x proteins from Streptococcus pneumoniae. Involvement of acylation and deacylation in beta-lactam resistance

21 January 2018

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Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams

21 January 2018

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Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants

21 January 2018

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Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae

21 January 2018

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Alterations to penicillin-binding proteins 1A, 2B and 2X amongst penicillin-resistant clinical isolates of Streptococcus pneumoniae serotype 23F from the nasopharyngeal flora of children.

21 January 2018

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Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance

21 January 2018

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Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

21 January 2018

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Alterations of penicillin-binding proteins 1A, 2X, and 2B in Streptococcus pneumoniae isolates for which amoxicillin MICs are higher than penicillin MICs

21 January 2018

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Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain

21 January 2018

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PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci

21 January 2018

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Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate

21 January 2018

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Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae

21 January 2018

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Analysis of penicillin-binding protein lb and 2a genes from Streptococcus pneumoniae

21 January 2018

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Automated high-throughput process for site-directed mutagenesis, production, purification, and kinetic characterization of enzymes

21 January 2018

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Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae.

21 January 2018

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Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics

21 January 2018

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The genome of Streptococcus mitis B6--what is a commensal?

21 January 2018

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Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan

21 January 2018

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Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.

21 January 2018

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A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci

21 January 2018

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Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae

21 January 2018

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The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcuspneumoniae

21 January 2018

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Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.

21 January 2018

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Separation of abnormal cell wall composition from penicillin resistance through genetic transformation of Streptococcus pneumoniae

21 January 2018

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Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance

21 January 2018

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Comparative genome analysis of high-level penicillin resistance in Streptococcus pneumoniae.

21 January 2018

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Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae

21 January 2018

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beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins

21 January 2018

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A novel resistance mechanism against beta-lactams in Streptococcus pneumoniae involves CpoA, a putative glycosyltransferase

21 January 2018

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Structural features of glycosyltransferases synthesizing major bilayer and nonbilayer-prone membrane lipids in Acholeplasma laidlawii and Streptococcus pneumoniae

21 January 2018

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A new model of pneumococcal lipoteichoic acid structure resolves biochemical, biosynthetic, and serologic inconsistencies of the current model

21 January 2018

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A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae

21 January 2018

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Effect of new alleles of the histidine kinase gene ciaH on the activity of the response regulator CiaR in Streptococcus pneumoniae R6.

21 January 2018

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The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance

21 January 2018

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Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis

21 January 2018

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Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization

21 January 2018

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A genomic analysis of two-component signal transduction in Streptococcus pneumoniae

21 January 2018

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Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae

21 January 2018

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Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs

21 January 2018

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The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins

21 January 2018

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Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae

21 January 2018

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The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro

21 January 2018

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Decrease in penicillin susceptibility due to heat shock protein ClpL in Streptococcus pneumoniae.

21 January 2018

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Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins

21 January 2018

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Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening

21 January 2018

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Understanding the acylation mechanisms of active-site serine penicillin-recognizing proteins: a molecular dynamics simulation study

21 January 2018

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Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FMB.12.2

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26 August 2017

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