The cellular and signaling networks linking the immune system and metabolism in disease (Q37991199)

26 August 2017

The cellular and signaling networks linking the immune system and metabolism in disease (English)

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26 August 2017

2

Jerrold M Olefsky

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26 August 2017

Olivia Osborn

1

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PubMed ID

22395709

26 August 2017

language of work or name

English

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publication date

6 March 2012

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26 August 2017

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26 August 2017

18

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26 August 2017

363-374

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26 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nm.2627

26 August 2017

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cites work

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

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12 December 2020

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

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12 December 2020

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

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12 December 2020

Adipokines in inflammation and metabolic disease

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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12 December 2020

Serial changes in inflammatory biomarkers after Roux-en-Y gastric bypass surgery

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12 December 2020

PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance

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12 December 2020

Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice

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Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

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12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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12 December 2020

Chemokines control fat accumulation and leptin secretion by cultured human adipocytes

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12 December 2020

Obesity decreases perioperative tissue oxygenation

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12 December 2020

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

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12 December 2020

Beneficial effects of subcutaneous fat transplantation on metabolism

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12 December 2020

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

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12 December 2020

TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome

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12 December 2020

Fractalkine is a novel human adipochemokine associated with type 2 diabetes

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12 December 2020

Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response

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12 December 2020

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

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12 December 2020

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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12 December 2020

The expression of TNF alpha by human muscle. Relationship to insulin resistance

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12 December 2020

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity.

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12 December 2020

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects.

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12 December 2020

Diet, gut microbiota and immune responses

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12 December 2020

Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function

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12 December 2020

High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation

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12 December 2020

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

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12 December 2020

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis

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12 December 2020

Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance

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12 December 2020

Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle

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12 December 2020

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

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12 December 2020

Microglia as a source and target of cytokines

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12 December 2020

HIF-1alpha is essential for myeloid cell-mediated inflammation

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12 December 2020

IKK-beta links inflammation to obesity-induced insulin resistance

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12 December 2020

Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

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12 December 2020

Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis

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12 December 2020

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

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12 December 2020

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

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12 December 2020

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

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12 December 2020

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

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12 December 2020

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.

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12 December 2020

Gut microbiome, obesity, and metabolic dysfunction

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12 December 2020

Krüppel-like factor 4 regulates macrophage polarization

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12 December 2020

Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

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12 December 2020

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

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12 December 2020

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats

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12 December 2020

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

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12 December 2020

Genetics of gene expression and its effect on disease

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12 December 2020

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

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12 December 2020

Adipocyte CREB promotes insulin resistance in obesity

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12 December 2020

A central role for JNK in obesity and insulin resistance

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12 December 2020

Gene profiling of human adipose tissue during evoked inflammation in vivo

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12 December 2020

TLR4 links innate immunity and fatty acid-induced insulin resistance

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12 December 2020

Type 2 diabetes as an inflammatory disease

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12 December 2020

Macrophages, inflammation, and insulin resistance

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12 December 2020

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

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12 December 2020

Insulin sensitivity: modulation by nutrients and inflammation

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12 December 2020

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

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12 December 2020

The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization

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12 December 2020

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice

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12 December 2020

Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

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12 December 2020

Interleukin 6 plays a key role in the development of antigen-induced arthritis

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12 December 2020

Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice

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12 December 2020

Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study

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12 December 2020

Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia

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12 December 2020

The microglial cell. A historical review

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12 December 2020

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

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12 December 2020

Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity

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12 December 2020

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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12 December 2020

Human nutrition, the gut microbiome and the immune system

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12 December 2020

How safe is the use of thiazolidinediones in clinical practice?

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12 December 2020

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

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12 December 2020

Splanchnic lipolysis in human obesity

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12 December 2020

Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding

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12 December 2020

Interleukin-6 and diabetes: the good, the bad, or the indifferent?

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12 December 2020

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

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12 December 2020

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

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12 December 2020

Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice

1 reference

12 December 2020

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1 reference

12 December 2020

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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12 December 2020

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

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12 December 2020

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

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12 December 2020

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages

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12 December 2020

Mast cell content and fatty acid metabolism in the epididymal fat pad of obese mice

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12 December 2020

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance

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12 December 2020

Variations in DNA elucidate molecular networks that cause disease

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12 December 2020

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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12 December 2020

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

1 reference

12 December 2020

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

1 reference

12 December 2020

Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells

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12 December 2020

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

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12 December 2020

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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12 December 2020

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

1 reference

12 December 2020

Obesity is associated with macrophage accumulation in adipose tissue

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12 December 2020

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

1 reference

12 December 2020

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

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12 December 2020

Developmental origin of fat: tracking obesity to its source.

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12 December 2020

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

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12 December 2020

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

1 reference

12 December 2020

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

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12 December 2020

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

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12 December 2020

Ceramide activates heterotrimeric protein phosphatase 2A.

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12 December 2020

Leukotriene B: a potential mediator of inflammation

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12 December 2020

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

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12 December 2020

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

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12 December 2020

Metabolic effects of visceral fat accumulation in type 2 diabetes

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12 December 2020

The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes

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12 December 2020

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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12 December 2020

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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12 December 2020

Recent advances in the relationship between obesity, inflammation, and insulin resistance.

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

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12 December 2020

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

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12 December 2020

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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12 December 2020

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

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12 December 2020

On the Treatment of Glycosuria and Diabetes Mellitus with Sodium Salicylate

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12 December 2020

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

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12 December 2020

Increased number of islet-associated macrophages in type 2 diabetes.

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

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12 December 2020

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

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12 December 2020

Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis

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12 December 2020

Mechanisms linking obesity to insulin resistance and type 2 diabetes

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12 December 2020

Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

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12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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12 December 2020

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

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12 December 2020

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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12 December 2020

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

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12 December 2020

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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12 December 2020

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

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12 December 2020

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

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12 December 2020

Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation

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12 December 2020

The metabolic effects of tumor necrosis factor and other cytokines

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12 December 2020

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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12 December 2020

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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12 December 2020

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

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12 December 2020

Normalization of obesity-associated insulin resistance through immunotherapy

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12 December 2020

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

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12 December 2020

Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity

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12 December 2020

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

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12 December 2020

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

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12 December 2020

Leukocyte influx in atherosclerosis

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12 December 2020

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

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12 December 2020

Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

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12 December 2020

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

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12 December 2020

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

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12 December 2020

Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice

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12 December 2020

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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12 December 2020

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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12 December 2020

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

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12 December 2020

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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12 December 2020

Kupffer cell activation is a causal factor for hepatic insulin resistance

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12 December 2020

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

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12 December 2020

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

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12 December 2020

Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity

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12 December 2020

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

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12 December 2020

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

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12 December 2020

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

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12 December 2020

SOCS-3 is an insulin-induced negative regulator of insulin signaling

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12 December 2020

Regulation of PPARgamma function by TNF-alpha

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12 December 2020

Identifiers

DOI

10.1038/NM.2627

1 reference

PubMed ID

22395709

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22395709