MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (Q37992965)

26 August 2017

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (English)

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26 August 2017

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Amy E Pasquinelli

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PubMed ID

22411466

26 August 2017

language of work or name

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13 March 2012

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26 August 2017

Nature Reviews Genetics

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26 August 2017

13

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26 August 2017

271-282

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26 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrg3162

26 August 2017

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR

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Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

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Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.

21 January 2018

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Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans

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The impact of microRNAs on protein output

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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Widespread changes in protein synthesis induced by microRNAs

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

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MicroRNAs direct rapid deadenylation of mRNA

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

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Human let-7a miRNA blocks protein production on actively translating polyribosomes

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Short RNAs repress translation after initiation in mammalian cells.

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

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Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

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Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.

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Distance constraints between microRNA target sites dictate efficacy and cooperativity

21 January 2018

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Molecular architecture of a miRNA-regulated 3' UTR

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Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression

21 January 2018

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Relief of microRNA-mediated translational repression in human cells subjected to stress

21 January 2018

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Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

21 January 2018

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Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

21 January 2018

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HuR recruits let-7/RISC to repress c-Myc expression

21 January 2018

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

21 January 2018

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Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

21 January 2018

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A novel repeat domain that is often associated with RING finger and B-box motifs.

21 January 2018

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TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

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Active turnover modulates mature microRNA activity in Caenorhabditis elegans

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Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

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Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

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nhl-2 Modulates microRNA activity in Caenorhabditis elegans

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

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Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

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The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

21 January 2018

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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

21 January 2018

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Prolyl 4-hydroxylation regulates Argonaute 2 stability

21 January 2018

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Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.

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Phosphorylation of human Argonaute proteins affects small RNA binding.

21 January 2018

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Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.

21 January 2018

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

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Target-mediated protection of endogenous microRNAs in C. elegans

21 January 2018

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Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity

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21 January 2018

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Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells

21 January 2018

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Target mimicry provides a new mechanism for regulation of microRNA activity

21 January 2018

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A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA

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An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma

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21 January 2018

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21 January 2018

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

21 January 2018

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Expression of distinct RNAs from 3' untranslated regions

21 January 2018

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Identification of human microRNA targets from isolated argonaute protein complexes

21 January 2018

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Isolation of microRNA targets by miRNP immunopurification

21 January 2018

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Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance

21 January 2018

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A biochemical approach to identifying microRNA targets

21 January 2018

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Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

21 January 2018

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Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

21 January 2018

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A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

21 January 2018

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

21 January 2018

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The mechanism of eukaryotic translation initiation and principles of its regulation

21 January 2018

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Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

21 January 2018

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Molecular biology. Paring miRNAs through pairing

21 January 2018

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Emerging roles for natural microRNA sponges

21 January 2018

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The widespread regulation of microRNA biogenesis, function and decay

21 January 2018

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Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps

31 March 2020

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Assaying the polyadenylation state of mRNAs

31 March 2020

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The therapeutic potential of microRNA modulation.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22411466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22411466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3162

1 reference

26 August 2017

1 reference

PubMed ID

22411466