Lewy pathology and neurodegeneration in premotor Parkinson's disease (Q38003064)

26 August 2017

title

Lewy pathology and neurodegeneration in premotor Parkinson's disease (English)

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26 August 2017

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Kelly Del Tredici

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26 August 2017

Heiko Braak

series ordinal

2

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26 August 2017

language of work or name

English

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publication date

1 April 2012

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26 August 2017

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26 August 2017

volume

27

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26 August 2017

issue

5

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26 August 2017

page(s)

597-607

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

26 August 2017

cites work

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Alpha-synuclein in Lewy bodies

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

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The ubiquitin proteasome system in neuropathology

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Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.

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Amygdala pathology in Parkinson's disease

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Relationships between Lewy bodies and pale bodies in Parkinson's disease

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Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

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Staging of brain pathology related to sporadic Parkinson's disease

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

21 January 2018

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Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease

21 January 2018

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

21 January 2018

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

21 January 2018

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The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans

21 January 2018

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

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Pigments in aging: an overview

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Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

21 January 2018

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Neuropathology of synuclein aggregates

21 January 2018

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Emerging evidence for the neuroprotective role of alpha-synuclein

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Parkinson's disease and related neurodegenerative synucleinopathies linked to progressive accumulations of synuclein aggregates in brain

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Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms

21 January 2018

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Neuropathology of non-motor features of Parkinson disease

21 January 2018

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Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

21 January 2018

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Milestones in Parkinson's disease--clinical and pathologic features

21 January 2018

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

21 January 2018

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Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

21 January 2018

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Reduced striatal tyrosine hydroxylase in incidental Lewy body disease

21 January 2018

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Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy

21 January 2018

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21 January 2018

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The anterior olfactory nucleus in Parkinson's disease

21 January 2018

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Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease

21 January 2018

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Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications

21 January 2018

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Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

21 January 2018

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Poor and protracted myelination as a contributory factor to neurodegenerative disorders

21 January 2018

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Pain and death: neurodegenerative disease mechanisms in the nociceptor

21 January 2018

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Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

21 January 2018

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Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system

21 January 2018

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Preservation of hypothalamic dopaminergic neurons in Parkinson's disease

21 January 2018

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Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments

21 January 2018

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Lewy bodies in the lower sacral parasympathetic neurons of a patient with Parkinson's disease

21 January 2018

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Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway

21 January 2018

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Parkinson's disease with involvement of the parasympathetic ganglia

21 January 2018

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Neuropathology of autonomic nervous system in Parkinson's disease

21 January 2018

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The intermediolateral nucleus and Clarke's column in Parkinson's disease

21 January 2018

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The Parkinson's complex: parkinsonism is just the tip of the iceberg

21 January 2018

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Cardiac sympathetic denervation preceding motor signs in Parkinson disease

21 January 2018

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Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study

21 January 2018

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Non-motor symptoms in Parkinson's disease

21 January 2018

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Beyond tremor and rigidity: non-motor features of Parkinson's disease

21 January 2018

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What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

21 January 2018

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A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials

21 January 2018

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Parkinson's at risk syndrome: can Parkinson's disease be predicted?

21 January 2018

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Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism

21 January 2018

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Ultrastructure of Lewy bodies in the stellate ganglion

21 January 2018

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Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

21 January 2018

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Association of olfactory dysfunction with incidental Lewy bodies

21 January 2018

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Bowel movement frequency in late-life and incidental Lewy bodies

21 January 2018

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Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.

21 January 2018

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Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

21 January 2018

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Lewy body pathology involves cutaneous nerves

21 January 2018

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Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects

21 January 2018

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

21 January 2018

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Incidental Lewy body disease and preclinical Parkinson disease

21 January 2018

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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

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Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease

21 January 2018

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Lewy body pathology in normal elderly subjects

21 January 2018

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Premotor Parkinson's disease: clinical features and detection strategies

21 January 2018

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Incidental Lewy body disease: clinical comparison to a control cohort

21 January 2018

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Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

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Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease

21 January 2018

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The progression of pathology in longitudinally followed patients with Parkinson's disease.

21 January 2018

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Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations

21 January 2018

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Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders

21 January 2018

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Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

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Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model

21 January 2018

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Parkinson's disease: before the motor symptoms and beyond

21 January 2018

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Lewy bodies in the sinoatrial nodal ganglion: clinicopathological studies.

21 January 2018

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Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study

21 January 2018

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Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease

21 January 2018

1 reference

Is Parkinson's disease a primary olfactory disorder?

21 January 2018

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Olfaction in neurodegenerative disorder

21 January 2018

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Alpha-synuclein pathology in the olfactory pathways of dementia patients

21 January 2018

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Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb

21 January 2018

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

21 January 2018

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Parkinson's disease: a dual-hit hypothesis

21 January 2018

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

21 January 2018

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Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease

21 January 2018

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Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers

21 January 2018

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Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves

21 January 2018

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Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?

21 January 2018

1 reference

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

21 January 2018

1 reference

The propagation of prion-like protein inclusions in neurodegenerative diseases

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

21 January 2018

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Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease

21 January 2018

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The olfactory vector hypothesis of neurodegenerative disease: is it viable?

21 January 2018

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Idiopathic hyposmia as a preclinical sign of Parkinson's disease

21 January 2018

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Association of olfactory dysfunction with risk for future Parkinson's disease

21 January 2018

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Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

21 January 2018

1 reference

Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder

21 January 2018

1 reference

Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation

21 January 2018

1 reference

The locus ceruleus norepinephrine system: functional organization and potential clinical significance

21 January 2018

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The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

21 January 2018

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The locus coeruleus and noradrenergic modulation of cognition

21 January 2018

1 reference

Parkinson's disease with depression: a possible subgroup of idiopathic parkinsonism.

21 January 2018

1 reference

Symptoms and duration of the prodromal phase in Parkinson's disease.

21 January 2018

1 reference

Higher incidence of depression preceding the onset of Parkinson's disease: a register study

21 January 2018

1 reference

Pain mechanisms: labeled lines versus convergence in central processing

21 January 2018

1 reference

Nociceptive processing in the human brain

21 January 2018

1 reference

Mechanisms of Disease: neuropathic pain—a clinical perspective

21 January 2018

1 reference

Pain in Parkinson's disease and multiple sclerosis: its relation to the medial and lateral pain systems

21 January 2018

1 reference

Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease

21 January 2018

1 reference

Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease correlate with major autonomic symptoms?

21 January 2018

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Idiopathic REM sleep behavior disorder in the transition to degenerative disease

21 January 2018

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Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder

21 January 2018

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Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

21 January 2018

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Clinostatic hypertension and orthostatic hypotension

21 January 2018

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Quantitative study of salivary secretion in Parkinson's disease

21 January 2018

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Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

21 January 2018

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A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

21 January 2018

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Brainstem circuits regulating gastric function

21 January 2018

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Enteric nervous system: functional organization and neurologic implications

21 January 2018

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Neural control of the gastrointestinal tract: implications for Parkinson disease

21 January 2018

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Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.

21 January 2018

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Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes

21 January 2018

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Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation--critique and recommendations by movement disorders task force on rating scales for Parkinson's disease

21 January 2018

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Medical records documentation of constipation preceding Parkinson disease: A case-control study

21 January 2018

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Research evaluation and prospective diagnosis of dementia with Lewy bodies.

21 January 2018

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Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease

21 January 2018

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Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy

21 January 2018

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Neuropathology underlying clinical variability in patients with synucleinopathies

21 January 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

21 January 2018

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Cell-to-cell transmission of non-prion protein aggregates.

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Can Parkinson's disease pathology be propagated from one neuron to another?

21 January 2018

1 reference

Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).

21 January 2018

1 reference

Non-motor symptoms of Parkinson's disease: diagnosis and management

21 January 2018

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Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients.

21 January 2018

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Patterns of motor and non-motor features in Parkinson's disease.

21 January 2018

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Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?

21 January 2018

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Clinical subtypes of Parkinson's disease

21 January 2018

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Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.24921

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26 August 2017

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