Toward mechanical systems biology in bone (Q38012387)

27 August 2017

title

Toward mechanical systems biology in bone (English)

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27 August 2017

Andreas Trüssel

1

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27 August 2017

Ralph Müller

series ordinal

2

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27 August 2017

Duncan Webster

series ordinal

3

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27 August 2017

publication date

22 May 2012

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Annals of Biomedical Engineering

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

11

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27 August 2017

page(s)

2475-2487

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Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress.

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Trabecular surface remodeling simulation for cancellous bone using microstructural voxel finite element models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Orientation of collagen at the osteocyte lacunae in human secondary osteons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A method of quantification of stress shielding in the proximal femur using hierarchical computational modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Osteocytes, mechanosensing and Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

FieldML: concepts and implementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Numerical modeling of bone tissue adaptation--a hierarchical approach for bone apparent density and trabecular structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Laser capture microdissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A unifying principle relating stress to trabecular bone morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

In silico biology of bone modelling and remodelling: adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Differential effect of steady versus oscillating flow on bone cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Automated three-dimensional finite element modelling of bone: a new method

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mechanobiology of bone tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts--correlation with prostaglandin upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Top down and bottom up engineering of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mathematical modeling and analysis of force induced bone growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Microfluidic single-cell mRNA isolation and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mechanotransduction of bone cells in vitro: mechanobiology of bone tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Model structure and control of bone remodeling: a theoretical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Prediction of bone adaptation using damage accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

The TEM characterization of the lamellar structure of osteoporotic human trabecular bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A theoretical framework for strain-related trabecular bone maintenance and adaptation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Mathematical modeling of spatio-temporal dynamics of a single bone multicellular unit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Identification of expressed genes by laser-mediated manipulation of single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A multiscale framework based on the physiome markup languages for exploring the initiation of osteoarthritis at the bone-cartilage interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

mRNA-Seq whole-transcriptome analysis of a single cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

MicroRNA expression profiling of single whole embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Cancellous bone adaptation to in vivo loading in a rabbit model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A novel in vivo mouse model for mechanically stimulated bone adaptation--a combined experimental and computational validation study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

In silico models of bone remodeling from macro to nano--from organ to cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

High-throughput microfluidic single-cell RT-qPCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Matrix-embedded cells control osteoclast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

MLO-Y4 osteocyte-like cells support osteoclast formation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

A microfluidic processor for gene expression profiling of single human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0594-4

10.1007/S10439-012-0594-4

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1033688074

0 references

1 reference