TRP channels as therapeutic targets in airway disorders: a patent review (Q38016197)

27 August 2017

TRP channels as therapeutic targets in airway disorders: a patent review (English)

1 reference

27 August 2017

Delia Preti

1

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author name string

Arpad Szallasi

series ordinal

2

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PubMed ID

22667456

27 August 2017

Riccardo Patacchini

series ordinal

3

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PubMed ID

22667456

27 August 2017

language of work or name

English

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publication date

6 June 2012

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Expert Opinion on Therapeutic Patents

27 August 2017

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27 August 2017

22

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27 August 2017

6

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27 August 2017

663-695

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The global burden of asthma: executive summary of the GINA Dissemination Committee report

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

New targets for drug development in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

WHO universal definition of severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

COPD as a disease of accelerated lung aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Burden and pathogenesis of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

New therapeutic options in the management of COPD - focus on roflumilast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Clinical cough II: therapeutic treatments and management of chronic cough

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The role of transient receptor potential channels in respiratory symptoms and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Transient receptor potential cation channels in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Transient receptor potential channels as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRP channels: emerging targets for respiratory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

On the putative role of transient receptor potential cation channels in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPA1 mediates formalin-induced pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Occupational asthma: current concepts in pathogenesis, diagnosis, and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The menthol receptor TRPM8 is the principal detector of environmental cold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPA1 contributes to cold hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Sensing pulmonary oxidative stress by lung vagal afferents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Transient receptor potential A1 channels: insights into cough and airway inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

A role for sensory nerves in the late asthmatic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPM8 biology and medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPM8 mechanism of autonomic nerve response to cold in respiratory airway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Menthol: effects on nasal sensation of airflow and the drive to breathe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Does inhaling menthol affect nasal patency or cough?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Effect of inhaled menthol on citric acid induced cough in normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

5-benzyloxytryptamine as an antagonist of TRPM8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The capsaicin receptor: a heat-activated ion channel in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Protons: small stimulants of capsaicin-sensitive sensory nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The cloned capsaicin receptor integrates multiple pain-producing stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Sensory neuropeptide involvement in animal models of airway irritation and of allergen-evoked asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Characterization of acid signaling in rat vagal pulmonary sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Antitussive activity of iodo-resiniferatoxin in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Acid stress in the pathology of asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Gastroesophageal reflux: a potential asthma trigger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The transient receptor potential vanilloid 1: role in airway inflammation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Cough receptor sensitivity and bronchial responsiveness in patients with only chronic nonproductive cough: in view of effect of bronchodilator therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPV1: a therapy target that attracts the pharmaceutical interests

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

TRPC1, a human homolog of a Drosophila store-operated channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.696099

10.1517/13543776.2012.696099

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22667456