Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma (Q38018840)

27 August 2017

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma (English)

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27 August 2017

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3

Robert N Weinreb

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27 August 2017

Kang Zhang

1

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PubMed ID

22699774

27 August 2017

Liangfang Zhang

series ordinal

2

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27 August 2017

15 June 2012

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Nature Reviews Drug Discovery

27 August 2017

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27 August 2017

11

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27 August 2017

7

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27 August 2017

541-559

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https://scigraph.springernature.com/pub.10.1038/nrd3745

27 August 2017

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

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Fas ligand (CD95 ligand) controls angiogenesis beneath the retina

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Racial variations in causes of vision loss in nursing homes: The Salisbury Eye Evaluation in Nursing Home Groups (SEEING) Study

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Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

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Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

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Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis.

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Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

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Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

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Drusen complement components C3a and C5a promote choroidal neovascularization

31 March 2020

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Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy

31 March 2020

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

31 March 2020

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Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy

31 March 2020

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Oxidative damage-induced inflammation initiates age-related macular degeneration.

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Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

31 March 2020

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Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration

31 March 2020

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Retinopathy in mice induced by disrupted all-trans-retinal clearance

31 March 2020

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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

31 March 2020

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Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

31 March 2020

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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

31 March 2020

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Biologic risk factors associated with diabetic retinopathy: the Los Angeles Latino Eye Study

31 March 2020

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Genetic susceptibility of diabetic retinopathy.

31 March 2020

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Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma

31 March 2020

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31 March 2020

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Risk assessment in the management of patients with ocular hypertension

31 March 2020

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Ranibizumab versus verteporfin for neovascular age-related macular degeneration.

31 March 2020

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Ranibizumab for neovascular age-related macular degeneration

31 March 2020

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Images in clinical medicine. Myositis ossificans

31 March 2020

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Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration

31 March 2020

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Baseline correlates of inconsistent and incorrect condom use among sexually active women in the contraceptive CHOICE Project

31 March 2020

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A phase 1 study of KH902, a vascular endothelial growth factor receptor decoy, for exudative age-related macular degeneration

31 March 2020

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A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration.

31 March 2020

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Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study

31 March 2020

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Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

31 March 2020

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Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

31 March 2020

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Glaucoma medical treatment: philosophy, principles and practice.

31 March 2020

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Medical backgrounders: glaucoma.

31 March 2020

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Topical prostaglandin F2alpha treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway

31 March 2020

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Comparison of the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure

31 March 2020

1 reference

Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy

31 March 2020

1 reference

Diurnal and nocturnal effects of brimonidine monotherapy on intraocular pressure

31 March 2020

1 reference

Effects of brimonidine on aqueous humor dynamics in human eyes

31 March 2020

1 reference

Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments

31 March 2020

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Complement factor H polymorphism and age-related macular degeneration

31 March 2020

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Complement factor H variant increases the risk of age-related macular degeneration

31 March 2020

1 reference

Complement factor H polymorphism in age-related macular degeneration

31 March 2020

1 reference

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration

31 March 2020

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Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

31 March 2020

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Complement C3 variant and the risk of age-related macular degeneration

31 March 2020

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Variation near complement factor I is associated with risk of advanced AMD

31 March 2020

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Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

31 March 2020

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Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator.

31 March 2020

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Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

31 March 2020

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Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

31 March 2020

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Inhibition of oxygen-induced retinopathy in RTP801-deficient mice

31 March 2020

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

31 March 2020

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

31 March 2020

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Activation of the interferon system by short-interfering RNAs

31 March 2020

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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

31 March 2020

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Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration

31 March 2020

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Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration.

31 March 2020

1 reference

Preclinical safety evaluation of AAV2-sFLT01- a gene therapy for age-related macular degeneration

31 March 2020

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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

31 March 2020

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Corneal avascularity is due to soluble VEGF receptor-1

31 March 2020

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The biology of VEGF and its receptors

31 March 2020

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CCR3 is a target for age-related macular degeneration diagnosis and therapy

31 March 2020

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Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib

31 March 2020

1 reference

Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related [...]

31 March 2020

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Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.

31 March 2020

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Topical mecamylamine for diabetic macular edema

31 March 2020

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Sphingosine-1-phosphate Signaling in Endothelial Activation

31 March 2020

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Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing

31 March 2020

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Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

31 March 2020

1 reference

Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization

31 March 2020

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Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin.

31 March 2020

1 reference

Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization

31 March 2020

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Relationship between vision impairment and eye disease to vision-specific quality of life and function in rural India: the Aravind Comprehensive Eye Survey.

31 March 2020

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Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization

31 March 2020

1 reference

Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.

31 March 2020

1 reference

Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization

31 March 2020

1 reference

Sustained effect of travoprost on diurnal and nocturnal intraocular pressure

31 March 2020

1 reference

Monitoring intraocular pressure for 24 h.

31 March 2020

1 reference

Inhibition of actin polymerization by latrunculin A.

31 March 2020

1 reference

Novel ocular antihypertensive compounds in clinical trials

31 March 2020

1 reference

Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension

31 March 2020

1 reference

A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine

31 March 2020

1 reference

Microarray analysis of iris gene expression in mice with mutations influencing pigmentation

31 March 2020

1 reference

Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits

31 March 2020

1 reference

Potential role of Rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery

31 March 2020

1 reference

Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys.

31 March 2020

1 reference

Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes

31 March 2020

1 reference

Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys

31 March 2020

1 reference

Marihuana Smoking and Intraocular Pressure

31 March 2020

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Effects of photodynamic therapy on rapidly growing nontuberculous mycobacteria keratitis.

31 March 2020

1 reference

A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension

31 March 2020

1 reference

Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements

31 March 2020

1 reference

Ophthalmic drug discovery

31 March 2020

1 reference

Neuroprotective efficacy of repinotan HCl, a 5-HT1A receptor agonist, in animal models of stroke and traumatic brain injury

31 March 2020

1 reference

The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization

31 March 2020

1 reference

The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha

31 March 2020

1 reference

Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation

31 March 2020

1 reference

Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress.

31 March 2020

1 reference

Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage.

31 March 2020

1 reference

The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

31 March 2020

1 reference

Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model

31 March 2020

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Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor

31 March 2020

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Distribution of CNTF receptor alpha protein in the central nervous system of the chick embryo.

31 March 2020

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Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light

31 March 2020

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Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse

31 March 2020

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Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse

31 March 2020

1 reference

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

31 March 2020

1 reference

Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons

31 March 2020

1 reference

A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study

31 March 2020

1 reference

Multivariate analysis in glaucoma. Use of discriminant analysis in predicting glaucomatous visual field damage

31 March 2020

1 reference

Genetic Risk of Primary Open-angle Glaucoma

31 March 2020

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Genetic etiologies of glaucoma

31 March 2020

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Identification of a gene that causes primary open angle glaucoma.

31 March 2020

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Common genetic variants associated with open-angle glaucoma

31 March 2020

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Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

31 March 2020

1 reference

Heritability of proliferative diabetic retinopathy

31 March 2020

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Heritability of the severity of diabetic retinopathy: the FIND-Eye study

31 March 2020

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Diabetic retinopathy in a multi-ethnic cohort in the United States

31 March 2020

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Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

31 March 2020

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Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors.

31 March 2020

1 reference

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

31 March 2020

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Genetic association of apolipoprotein E with age-related macular degeneration

31 March 2020

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Effect of gene therapy on visual function in Leber's congenital amaurosis

31 March 2020

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

31 March 2020

1 reference

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

31 March 2020

1 reference

Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

31 March 2020

1 reference

A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

31 March 2020

1 reference

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

31 March 2020

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Induced pluripotent stem cell therapies for geographic atrophy of age-related macular degeneration.

31 March 2020

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Stem cells and eye development

31 March 2020

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Direct reprogramming of mouse fibroblasts to neural progenitors

31 March 2020

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Challenges and obstacles of ocular pharmacokinetics and drug delivery

31 March 2020

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Drug delivery to the posterior segment of the eye.

31 March 2020

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Encapsulated cell technology could prevent blindness

31 March 2020

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Application of encapsulated cell technology for retinal degenerative diseases

31 March 2020

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Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants

31 March 2020

1 reference

Intravitreal cell-based production of glucagon-like peptide-1.

31 March 2020

1 reference

Strategies in the design of nanoparticles for therapeutic applications

31 March 2020

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Nanotechnology in drug delivery and tissue engineering: from discovery to applications

31 March 2020

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Nanotechnology in ocular delivery: current and future directions

31 March 2020

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Nanoparticles in medicine: therapeutic applications and developments

31 March 2020

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A novel intracellular protein delivery platform based on single-protein nanocapsules

31 March 2020

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Retinal angiogenesis in development and disease

31 March 2020

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Knocking down barriers: advances in siRNA delivery

31 March 2020

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Ocular drug delivery - a look towards nanobioadhesives

31 March 2020

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Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

31 March 2020

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The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey

31 March 2020

1 reference

Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models

31 March 2020

1 reference

A comparison of dorzolamide-timolol combination versus the concomitant drugs

31 March 2020

1 reference

Brimonidine and timolol fixed-combination therapy versus monotherapy: a 3-month randomized trial in patients with glaucoma or ocular hypertension.

31 March 2020

1 reference

A comparison of the fixed combination of latanoprost and timolol with its individual components

31 March 2020

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Latanoprost and timolol combination therapy vs monotherapy: one-year randomized trial

31 March 2020

1 reference

Efficacy and safety of a fixed combination of travoprost 0.004%/timolol 0.5% ophthalmic solution once daily for open-angle glaucoma or ocular hypertension

31 March 2020

1 reference

A double-masked, randomized, parallel comparison of a fixed combination of bimatoprost 0.03%/timolol 0.5% with non-fixed combination use in patients with glaucoma or ocular hypertension

31 March 2020

1 reference

Pharmacologic vitreolysis

31 March 2020

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Posterior vitreous detachment induced by microplasmin

31 March 2020

1 reference

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

31 March 2020

1 reference

12 December 2020

Human ciliary process adrenergic receptor: pharmacological characterization

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12 December 2020

Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations

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12 December 2020

Molecular composition of drusen as related to substructural phenotype

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12 December 2020

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

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12 December 2020

Ciliary neurotrophic factor promotes chick photoreceptor development in vitro

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12 December 2020

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

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12 December 2020

Metalloproteinase gene transcription in human ciliary muscle cells with latanoprost

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12 December 2020

The safety and efficacy of travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution

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12 December 2020

Latrunculins' effects on intraocular pressure, aqueous humor flow, and corneal endothelium

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12 December 2020

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors

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12 December 2020

Global data on visual impairment in the year 2002

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12 December 2020

Prevalence of age-related macular degeneration in the United States

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12 December 2020

Ranibizumab and bevacizumab for neovascular age-related macular degeneration

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12 December 2020

Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension

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12 December 2020

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs

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12 December 2020

Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor

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12 December 2020

Topical carbonic anhydrase inhibitors: a new perspective in glaucoma therapy

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12 December 2020

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature

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12 December 2020

Retinal degeneration and RPE transplantation in Rpe65(-/-) mice

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12 December 2020

Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization

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12 December 2020

The possibility of selective Rho-associated kinase (ROCK) inhibitors as a medical treatment for glaucoma

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12 December 2020

Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.

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12 December 2020

Protection of mouse photoreceptors by survival factors in retinal degenerations.

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12 December 2020

Senile macular degeneration: a histopathologic study

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12 December 2020

Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

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12 December 2020

Poor provider adherence to the Centers for Disease Control and Prevention treatment guidelines in US emergency department visits with a diagnosis of pelvic inflammatory disease

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12 December 2020

Identifiers

DOI

10.1038/NRD3745

1 reference

27 August 2017

1 reference

PubMed ID

22699774