Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms (Q38021241)

27 August 2017

title

Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms (English)

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protein-protein interaction

27 August 2017

main subject

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Klaus Scheffzek

1

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27 August 2017

Stefan Welti

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

19 June 2012

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27 August 2017

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27 August 2017

volume

586

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27 August 2017

issue

17

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27 August 2017

page(s)

2662-2673

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A putative modular domain present in diverse signaling proteins

27 August 2017

cites work

1 reference

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Solution structure of a pleckstrin-homology domain

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The PH superfold: a structural scaffold for multiple functions

21 January 2018

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Pleckstrin homology domains and the cytoskeleton

21 January 2018

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Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

21 January 2018

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In vivo functional analysis of the Ras exchange factor son of sevenless

21 January 2018

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The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling

21 January 2018

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Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

21 January 2018

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Pleckstrin homology domains: not just for phosphoinositides

21 January 2018

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

21 January 2018

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Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

21 January 2018

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Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

21 January 2018

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PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

21 January 2018

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Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

21 January 2018

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Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.

21 January 2018

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Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

21 January 2018

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Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

21 January 2018

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Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Rac Regulates Its Effector Phospholipase C 2 through Interaction with a Split Pleckstrin Homology Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Functional Reassembly of a Split PH Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain

21 January 2018

1 reference

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Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The role of the PH domain in the signal-dependent membrane targeting of Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural analysis of autoinhibition in the Ras activator Son of sevenless

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

ARF family G proteins and their regulators: roles in membrane transport, development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Regulation of phosphoinositide-specific phospholipase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Specificity and structural requirements of phospholipase C-beta stimulation by Rho GTPases versus G protein beta gamma dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

General and Versatile Autoinhibition of PLC Isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Molecular mechanism of the nuclear protein import cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

RanGAP mediates GTP hydrolysis without an arginine finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Ral-GTPases: approaching their 15 minutes of fame

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Ral GTPases and cancer: linchpin support of the tumorigenic platform

21 January 2018

1 reference

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Ral GTPases regulate exocyst assembly through dual subunit interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Dominant-negative inhibition of receptor-mediated endocytosis by a dynamin-1 mutant with a defective pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Endocytosis: How dynamin sets vesicles PHree!

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of nucleotide-free dynamin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The crystal structure of dynamin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Physiological roles of G protein-coupled receptor kinases and arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

21 January 2018

1 reference

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Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol-transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The general transcription machinery and general cofactors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

TFIIH contains a PH domain involved in DNA nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The FACT chromatin modulator: genetic and structure/function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The role of BEACH proteins in Dictyostelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Interaction between the SifA Virulence Factor and Its Host Target SKIP Is Essential for Salmonella Pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The intracellular fate of Salmonella depends on the recruitment of kinesin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

The Salmonella virulence protein SifA is a G protein antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

Crystal structure of Rac1 bound to its effector phospholipase C-β2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.06.006

10.1016/J.FEBSLET.2012.06.006

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference