Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. (Q38031743)

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9 February 2020

title

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons (English)

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9 February 2020

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1

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9 February 2020

author name string

Tamas L Horvath

series ordinal

2

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publication date

3 August 2012

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Nature Reviews Drug Discovery

9 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

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volume

11

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9 February 2020

page(s)

675-691

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issue

9

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https://scigraph.springernature.com/pub.10.1038/nrd3739

9 February 2020

exact match

0 references

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Dopamine is required for hyperphagia in Lep(ob/ob) mice

21 January 2018

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Leptin signaling in brain: A link between nutrition and cognition?

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Leptin regulates striatal regions and human eating behavior

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FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

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Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

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PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

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Suspense builds on anti-obesity rollercoaster ride

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Localization of a "feeding center" in the hypothalamus of the rat.

31 March 2020

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Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype

31 March 2020

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Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis

31 March 2020

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Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats

31 March 2020

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Diabetes, a New Mutation in the Mouse

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The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals.

31 March 2020

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A comparison of the effects of tryptamine and 5-hydroxytryptamine on feeding following injection into the paraventricular nucleus of the hypothalamus

31 March 2020

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A double-blind randomized placebo-controlled trial of sibutramine

31 March 2020

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Sibutramine reduces food intake in non-dieting women with obesity

31 March 2020

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A comparison of sibutramine and dexfenfluramine in the treatment of obesity

31 March 2020

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Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist

31 March 2020

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Rimonabant for overweight or obesity

31 March 2020

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Safety, tolerability, pharmacokinetics, and pharmacodynamic properties of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, for the treatment of obesity: results from a double-blind, placebo-controlled, single oral dose study in

31 March 2020

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Taranabant no longer developed as an antiobesity agent

31 March 2020

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Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study.

31 March 2020

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Identification of the 5-hydroxytryptamine2C receptor as a 60-kDa N-glycosylated protein in choroid plexus and hippocampus.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

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Evidence that GABA in the nucleus dorsalis raphé induces stimulation of locomotor activity and eating behavior

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Deconstruction of a neural circuit for hunger

31 March 2020

1 reference

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors

31 March 2020

1 reference

A one-year trial to assess the value of orlistat in the management of obesity

31 March 2020

1 reference

12 December 2020

Hypothalamic control of food intake in rats and cats

1 reference

12 December 2020

From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997

1 reference

12 December 2020

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene

1 reference

12 December 2020

Mode of action of orlistat

1 reference

12 December 2020

Genetic aspects of severe childhood obesity

1 reference

12 December 2020

Food for thought. Dietary change was a driving force in human evolution.

1 reference

12 December 2020

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

1 reference

12 December 2020

Cetilistat, a new lipase inhibitor for the treatment of obesity.

1 reference

12 December 2020

Naltrexone SR/Bupropion SR (Contrave): A New Approach to Weight Loss in Obese Adults

1 reference

12 December 2020

Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study

1 reference

12 December 2020

Rimonabant for overweight or obesity

1 reference

12 December 2020