Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens? (Q38040818)

27 August 2017

Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens? (English)

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27 August 2017

Saskia Decuypere

2

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Manu Vanaerschot

object named as

Manu Vanaerschot

1

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author name string

Maya Berg

3

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27 August 2017

Syamal Roy

4

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27 August 2017

Jean-Claude Dujardin

5

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27 August 2017

language of work or name

English

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publication date

6 September 2012

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Critical Reviews in Microbiology

27 August 2017

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27 August 2017

39

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27 August 2017

4

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27 August 2017

384-394

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Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif

27 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Compensatory evolution of pbp mutations restores the fitness cost imposed by β-lactam resistance in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

The relationship between leishmaniasis and AIDS: the second 10 years

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

The biological cost of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Ovothiol and trypanothione as antioxidants in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Impaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Molecular basis of antimony treatment in leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania interferes with host cell signaling to devise a survival strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Antimony Uptake Systems in the Protozoan Parasite Leishmania and Accumulation Differences in Antimony-Resistant Parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Sodium stibogluconate resistance in Leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Isoniazid resistance and the future of drug-resistant tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

The competitive cost of antibiotic resistance in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Use of antimony in the treatment of leishmaniasis: current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Reduction of Sb(V) in a human macrophage cell line measured by HPLC-ICP-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmaniasis: complexity at the host-pathogen interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Treatment of leishmaniasis in HIV-positive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Interplay in the selection of fluoroquinolone resistance and bacterial fitness

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Visceral leishmaniasis: elimination with existing interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Increase in cytosolic Ca2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Kala-azar as an AIDS-related opportunistic infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Modulation of T-Cell Costimulation as Immunotherapy or Immunochemotherapy in Experimental Visceral Leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania donovani vs immunity: T-cells sensitized from Leishmania of one donor may modulate their cytokines pattern on re-stimulation with Leishmania from different donor in visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Fitness and its role in evolutionary genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

The concept of virulence: interpretations and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Sodium stibogluconate (Pentostam) potentiates oxidant production in murine visceral leishmaniasis and in human blood

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Clinical risk factors for therapeutic failure in kala-azar patients treated with pentavalent antimonials in Nepal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Virulence and disease in leishmaniasis: what is relevant for the patient?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Visceral leishmaniasis and HIV-1 co-infection in southern France

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Fitness cost of chromosomal drug resistance-conferring mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Central carbon metabolism of Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Antimonial-induced Increase in Intracellular Ca2+ through Non-selective Cation Channels in the Host and the Parasite Is Responsible for Apoptosis of Intracellular Leishmania donovani Amastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Metabolomics to unveil and understand phenotypic diversity between pathogen populations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Escaping an evolutionary lobster trap: drug resistance and compensatory mutation in a fluctuating environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Skewing of cytokine profiles towards T helper cell type 2 response in visceral leishmaniasis patients unresponsive to sodium antimony gluconate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania-macrophage interactions: insights into the redox biology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Linking in vitro and in vivo survival of clinical Leishmania donovani strains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Reduction of pentavalent antimony by trypanothione and formation of a binary and ternary complex of antimony(III) and trypanothione.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Phospholipid and sphingolipid metabolism in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Developmentally regulated sphingolipid degradation in Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

Expression of IFN-gamma, TNF-alpha, IL-10 and TGF-beta in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2012.716818

10.3109/1040841X.2012.716818

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference