Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers (Q38042201)

27 August 2017

Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers (English)

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27 August 2017

Gijs A Versteeg

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Marjolein Kikkert

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3

object named as

Marjolein Kikkert

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27 August 2017

Diede Oudshoorn

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27 August 2017

8 September 2012

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Cytokine and Growth Factor Reviews

27 August 2017

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27 August 2017

23

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27 August 2017

6

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27 August 2017

273-282

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RIG-I and dsRNA-induced IFNbeta activation

27 August 2017

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12 December 2020

Modification of proteins by ubiquitin and ubiquitin-like proteins

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12 December 2020

TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation

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12 December 2020

The role of ubiquitylation in immune defence and pathogen evasion

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12 December 2020

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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12 December 2020

A diverse range of gene products are effectors of the type I interferon antiviral response

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12 December 2020

Transcription factor redundancy ensures induction of the antiviral state

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12 December 2020

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

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12 December 2020

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

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12 December 2020

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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12 December 2020

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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12 December 2020

The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories.

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12 December 2020

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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12 December 2020

Emerging role of ubiquitination in antiviral RIG-I signaling

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12 December 2020

Kaposi's sarcoma-associated herpesvirus encodes a viral deubiquitinase

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12 December 2020

IFI16 is an innate immune sensor for intracellular DNA

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12 December 2020

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

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12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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12 December 2020

NLRX1 is a regulator of mitochondrial antiviral immunity

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12 December 2020

Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice

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12 December 2020

Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis

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12 December 2020

Deubiquitinating function of adenovirus proteinase

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12 December 2020

Regulation of gene-activation pathways by PIAS proteins in the immune system

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12 December 2020

Expanding TRAF function: TRAF3 as a tri-faced immune regulator

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12 December 2020

PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

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12 December 2020

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

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12 December 2020

NEDD8 pathways in cancer, Sine Quibus Non.

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12 December 2020

Type I interferon in organ-targeted autoimmune and inflammatory diseases

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12 December 2020

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

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12 December 2020

Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses

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12 December 2020

NOD-like receptors: role in innate immunity and inflammatory disease

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12 December 2020

Immune Interferon in the Circulation of Patients with Autoimmune Disease

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12 December 2020

Deciphering the complexity of Toll-like receptor signaling

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12 December 2020

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

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12 December 2020

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

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12 December 2020

Regulation of NF-κB by deubiquitinases

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12 December 2020

Direct activation of protein kinases by unanchored polyubiquitin chains

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12 December 2020

TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

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12 December 2020

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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12 December 2020

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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12 December 2020

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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12 December 2020

SUMO: a history of modification

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12 December 2020

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

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12 December 2020

Ubiquitin makes its mark on immune regulation

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12 December 2020

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

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12 December 2020

Mechanisms, biology and inhibitors of deubiquitinating enzymes

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12 December 2020

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

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12 December 2020

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

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12 December 2020

Systematic and quantitative assessment of the ubiquitin-modified proteome

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12 December 2020

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction

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12 December 2020

The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis

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12 December 2020

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

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12 December 2020

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

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12 December 2020

Mechanisms underlying ubiquitination

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12 December 2020

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

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12 December 2020

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

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12 December 2020

DUBA: a deubiquitinase that regulates type I interferon production

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12 December 2020

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

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12 December 2020

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

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12 December 2020

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

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12 December 2020

ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation

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12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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12 December 2020

A genomic and functional inventory of deubiquitinating enzymes

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12 December 2020

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

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12 December 2020

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses

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12 December 2020

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

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12 December 2020

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

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12 December 2020

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

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12 December 2020

CARD15 mutations in Blau syndrome

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12 December 2020

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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12 December 2020

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

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12 December 2020

Ubiquitin-binding domains - from structures to functions

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12 December 2020

Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

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12 December 2020

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

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12 December 2020

The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.

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12 December 2020

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

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12 December 2020

Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

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12 December 2020

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

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12 December 2020

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

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12 December 2020

Evolution and function of ubiquitin-like protein-conjugation systems

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12 December 2020

Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts

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12 December 2020

Triggering the interferon antiviral response through an IKK-related pathway

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12 December 2020

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

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12 December 2020

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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12 December 2020

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

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12 December 2020

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

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12 December 2020

Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling

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12 December 2020

IFN-lambda determines the intestinal epithelial antiviral host defense

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12 December 2020

Innate recognition of viruses

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12 December 2020

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

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12 December 2020

Innate and adaptive immunity through autophagy

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12 December 2020

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

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12 December 2020

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

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12 December 2020

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

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12 December 2020

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

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12 December 2020

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

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12 December 2020

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin

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12 December 2020

Functional role of type I and type II interferons in antiviral defense

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12 December 2020

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

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12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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12 December 2020

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

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12 December 2020

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

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12 December 2020

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

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12 December 2020

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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12 December 2020

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors

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12 December 2020

Immune signaling by RIG-I-like receptors

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12 December 2020

Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression

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12 December 2020

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

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12 December 2020

Ubiquitylation in innate and adaptive immunity.

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12 December 2020

Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex

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12 December 2020

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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12 December 2020

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

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12 December 2020

Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains

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12 December 2020

The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

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12 December 2020

The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

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12 December 2020

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

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12 December 2020

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12 December 2020

Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.

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12 December 2020

Structure and function of Toll receptors and their ligands

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12 December 2020

Negative regulation of ISG15 E3 ligase EFP through its autoISGylation

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12 December 2020

10.1016/J.CYTOGFR.2012.08.003

Identifiers

DOI

1 reference

27 August 2017

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PubMed ID

22964110