Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis (Q38046124)

27 August 2017

Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis (English)

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27 August 2017

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Amiram Ariel

1

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PubMed ID

23007838

27 August 2017

Orly Timor

series ordinal

2

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27 August 2017

1 January 2013

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27 August 2017

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27 August 2017

229

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27 August 2017

2

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27 August 2017

250-263

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Nonresolving inflammation

27 August 2017

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

21 January 2018

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Cellular and molecular mechanisms of fibrosis

21 January 2018

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Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis

21 January 2018

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The myofibroblast in wound healing and fibrocontractive diseases

21 January 2018

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Macrophages: master regulators of inflammation and fibrosis

21 January 2018

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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

21 January 2018

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miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

21 January 2018

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Soluble transforming growth factor-beta1 receptor II might inhibit transforming growth factor-beta-induced myofibroblast differentiation and improve ischemic cardiac function after myocardial infarction in rats

21 January 2018

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Neutrophil clearance: when the party is over, clean-up begins

21 January 2018

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Resolution of inflammation: the beginning programs the end

21 January 2018

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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation

21 January 2018

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Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo

21 January 2018

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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

21 January 2018

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LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

21 January 2018

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Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids

21 January 2018

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Biological fate and clinical implications of arginine metabolism in tissue healing

21 January 2018

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Arginase: an emerging key player in the mammalian immune system

21 January 2018

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Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

21 January 2018

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Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression

21 January 2018

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Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway

21 January 2018

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An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis

21 January 2018

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Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis

21 January 2018

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Carbon monoxide suppresses bleomycin-induced lung fibrosis

21 January 2018

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Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells

21 January 2018

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Pathomechanisms of myocardial dysfunction in sepsis

21 January 2018

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Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study.

21 January 2018

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Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury

21 January 2018

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Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats

21 January 2018

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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

21 January 2018

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Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

21 January 2018

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Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.

21 January 2018

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Protective effect of annexin-A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat.

21 January 2018

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Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

21 January 2018

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Macrophage activation and polarization

21 January 2018

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Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease

21 January 2018

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Molecular circuits of resolution: formation and actions of resolvins and protectins

21 January 2018

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Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

21 January 2018

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Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10

21 January 2018

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Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis

21 January 2018

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IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin

21 January 2018

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BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

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BMP7 antagonizes TGF-beta -dependent fibrogenesis in mesangial cells

21 January 2018

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BMP signaling in rats with TNBS-induced colitis following BMP7 therapy.

21 January 2018

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Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

21 January 2018

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CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease

21 January 2018

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CCN3/CCN2 regulation and the fibrosis of diabetic renal disease

21 January 2018

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A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.

21 January 2018

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A novel role of CCN3 in regulating endothelial inflammation

21 January 2018

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NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9

21 January 2018

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Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing

21 January 2018

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Relaxin and its role in the development and treatment of fibrosis

21 January 2018

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Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

21 January 2018

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Relaxin regulates myofibroblast contractility and protects against lung fibrosis

21 January 2018

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The vascular actions of relaxin

21 January 2018

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Relaxin inhibits early steps in vascular inflammation.

21 January 2018

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Relaxin stimulates osteoclast differentiation and activation

21 January 2018

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RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway

21 January 2018

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Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kappaB pathway in human THP-1 cells

21 January 2018

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The inflammatory response to cell death

21 January 2018

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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

21 January 2018

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21 January 2018

Adenosine in fibrosis.

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Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice

21 January 2018

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Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation

21 January 2018

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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

21 January 2018

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Adenosine promotes alternative macrophage activation via A2A and A2B receptors

21 January 2018

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Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway

21 January 2018

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Pharmacological blockade of adenosine A2A receptors diminishes scarring

21 January 2018

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Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes.

21 January 2018

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Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3.

21 January 2018

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Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature

21 January 2018

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The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice

21 January 2018

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TGF-beta: a critical modulator of immune cell function

21 January 2018

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Latent-TGF-beta: an overview

21 January 2018

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Biology of transforming growth factor-β signaling

21 January 2018

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Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.

21 January 2018

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Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing

21 January 2018

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

21 January 2018

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Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages.

21 January 2018

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TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

21 January 2018

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Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

21 January 2018

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Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst.

21 January 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

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Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4

21 January 2018

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PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis

21 January 2018

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PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

21 January 2018

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NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease

21 January 2018

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IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent

21 January 2018

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Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

21 January 2018

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IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis

21 January 2018

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Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling

21 January 2018

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Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis

21 January 2018

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Natural versus adaptive regulatory T cells

21 January 2018

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Regulatory T cells and immune tolerance

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

21 January 2018

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TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

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Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis

21 January 2018

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Tregs promote the differentiation of Th17 cells in silica-induced lung fibrosis in mice

21 January 2018

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Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

21 January 2018

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p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

21 January 2018

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Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

21 January 2018

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Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors

21 January 2018

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Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players.

21 January 2018

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Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta

21 January 2018

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Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cells

21 January 2018

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Immunological consequences of apoptotic cell phagocytosis

21 January 2018

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Engulfment of apoptotic cells: signals for a good meal

21 January 2018

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A blast from the past: clearance of apoptotic cells regulates immune responses.

21 January 2018

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Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways

21 January 2018

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Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: Implications for the delayed clearance model of autoimmunity

21 January 2018

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Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells

21 January 2018

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Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells

21 January 2018

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PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

21 January 2018

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Phosphatidylserine exposure by Toxoplasma gondii is fundamental to balance the immune response granting survival of the parasite and of the host

21 January 2018

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iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-kappaB-dependent blockade

21 January 2018

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MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming

21 January 2018

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Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-α production in macrophages via STAT3-mediated SOCS3 activation

21 January 2018

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Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.

21 January 2018

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Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.

21 January 2018

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The chemokine system in diverse forms of macrophage activation and polarization

21 January 2018

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Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia

21 January 2018

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Blocking of monocyte chemoattractant protein-1 during tubulointerstitial nephritis resulted in delayed neutrophil clearance

21 January 2018

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Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation

21 January 2018

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Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis

21 January 2018

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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

21 January 2018

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Macrophage polarization comes of age.

21 January 2018

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Alternative activation of macrophages: an immunologic functional perspective

21 January 2018

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IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.

21 January 2018

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IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

21 January 2018

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Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

21 January 2018

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Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

21 January 2018

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Modulation of macrophage efferocytosis in inflammation

21 January 2018

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Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction.

21 January 2018

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Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

21 January 2018

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Pathways connecting inflammation and cancer

21 January 2018

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Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment

21 January 2018

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Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators

21 January 2018

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Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase

21 January 2018

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12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis

21 January 2018

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12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

21 January 2018

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Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

21 January 2018

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A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense

21 January 2018

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The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

21 January 2018

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The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering

21 January 2018

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Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins

21 January 2018

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Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

21 January 2018

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Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

21 January 2018

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Infection regulates pro-resolving mediators that lower antibiotic requirements

21 January 2018

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Transcriptomic analyses of murine resolution-phase macrophages

21 January 2018

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Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid

21 January 2018

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Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

21 January 2018

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Novel anti-inflammatory--pro-resolving mediators and their receptors

21 January 2018

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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

21 January 2018

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Lipoxin A4 is a novel estrogen receptor modulator.

21 January 2018

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The two faces of the 15-lipoxygenase in atherosclerosis

21 January 2018

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Resolvin E1 and protectin D1 activate inflammation-resolution programmes

21 January 2018

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Resolvin D1 binds human phagocytes with evidence for proresolving receptors

21 January 2018

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Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells

21 January 2018

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Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4.

21 January 2018

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Resolvin D series and protectin D1 mitigate acute kidney injury.

21 January 2018

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ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.

21 January 2018

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Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation.

21 January 2018

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Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.

21 January 2018

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Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands

21 January 2018

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Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses

21 January 2018

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Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity

21 January 2018

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PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease

21 January 2018

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Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

21 January 2018

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Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis

21 January 2018

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Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing

21 January 2018

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Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

21 January 2018

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BMP-7 functions as a novel hormone to facilitate liver regeneration

21 January 2018

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Immunosuppressive effects of apoptotic cells

21 January 2018

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An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4108

1 reference

27 August 2017

1 reference

PubMed ID

23007838