Neuroprotection and repair in multiple sclerosis (Q38048610)

27 August 2017

Neuroprotection and repair in multiple sclerosis (English)

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27 August 2017

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Robin J M Franklin

1

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27 August 2017

Charles ffrench-Constant

series ordinal

2

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27 August 2017

Julia M Edgar

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3

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27 August 2017

Kenneth J Smith

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4

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27 August 2017

language of work or name

English

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publication date

2 October 2012

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27 August 2017

Nature Reviews Neurology

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27 August 2017

8

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27 August 2017

624-634

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27 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2012.200

27 August 2017

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cites work

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Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection

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New concepts on progressive multiple sclerosis

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Axonal transection in the lesions of multiple sclerosis

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Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

21 January 2018

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Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes

21 January 2018

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Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion

21 January 2018

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Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

21 January 2018

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Oxidative damage in multiple sclerosis lesions

21 January 2018

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NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

21 January 2018

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Review: Mitochondria and disease progression in multiple sclerosis

21 January 2018

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Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease?

21 January 2018

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Sodium-mediated axonal degeneration in inflammatory demyelinating disease.

21 January 2018

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Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

21 January 2018

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Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis.

21 January 2018

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Mitochondrial changes within axons in multiple sclerosis

21 January 2018

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Mitochondrial defects in acute multiple sclerosis lesions

21 January 2018

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Newly lesioned tissue in multiple sclerosis--a role for oxidative damage?

21 January 2018

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Hypoxia. 2. Hypoxia regulates cellular metabolism

21 January 2018

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Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy

21 January 2018

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Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

21 January 2018

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Radical changes in multiple sclerosis pathogenesis

21 January 2018

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Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger

21 January 2018

1 reference

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Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.

21 January 2018

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Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors

21 January 2018

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Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Sodium channels and microglial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial.

21 January 2018

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The relation between inflammation and neurodegeneration in multiple sclerosis brains.

21 January 2018

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Multiple sclerosis: an immune or neurodegenerative disorder?

21 January 2018

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Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Evolution of a neuroprotective function of central nervous system myelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

The role of CNS glia in preserving axon function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Cellular and subcellular distribution of 2',3'-cyclic nucleotide 3'-phosphodiesterase and its mRNA in the rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelination in the absence of myelin-associated glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Nerve conduction abnormalities in aging mice deficient for myelin-associated glycoprotein.

21 January 2018

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Axonal protective effects of the myelin-associated glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Ultrastructural studies of the dying-back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseases axons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal transport defects in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Unwrapping new layers of complexity in axon/glial relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

The axo-myelinic synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelin-associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Why does remyelination fail in multiple sclerosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Remyelination can be extensive in multiple sclerosis despite a long disease course

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Remyelination is extensive in a subset of multiple sclerosis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Remyelination in the CNS: from biology to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

The role of SVZ-derived neural precursors in demyelinating diseases: from animal models to multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Origin of oligodendrocytes in the subventricular zone of the adult brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Central remyelination restores secure conduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Extensive remyelination of the CNS leads to functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal protection in multiple sclerosis--a particular need during remyelination?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Taking ageing into account in remyelination-based therapies for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Remyelination capacity of the MS brain decreases with disease chronicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Age at disability milestones in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Rejuvenation of regeneration in the aging central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Overcoming remyelination failure in multiple sclerosis and other myelin disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Enhancing remyelination in disease--can we wrap it up?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

LINGO-1 negatively regulates myelination by oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Retinoid X receptor gamma signaling accelerates CNS remyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Evolution of clinical and molecular responses to bexarotene treatment in cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Spontaneous and mechanically evoked activity due to central demyelinating lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

The initiation and prevention of multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Axonal protection achieved in a model of multiple sclerosis using lamotrigine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Assembly of CNS myelin in the absence of proteolipid protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Immunocytochemical localization by electron microscopy of 2'3'-cyclic nucleotide 3'-phosphodiesterase in developing oligodendrocytes of normal and mutant brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Formation of cytoplasm-containing vesicles from double-walled coated invaginations containing oligodendrocytic cytoplasm at the axon-myelin sheath interface in adult mammalian central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Focal accumulation of intra-axonal mitochondria in demyelination of the cat optic nerve

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Myelination and the trophic support of long axons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Remyelination in multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.200

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

31 March 2020

1 reference

12 December 2020

Can antioxidants be effective therapeutics?

1 reference

12 December 2020

Mitochondria--a neglected drug target

1 reference

12 December 2020

Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult

1 reference

12 December 2020

Neurofilament Phosphorylation during Development and Disease: Which Came First, the Phosphorylation or the Accumulation?

1 reference

12 December 2020

10.1038/NRNEUROL.2012.200

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

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1 reference