The multiple facets of glucocorticoid action in rheumatoid arthritis (Q38050401)

27 August 2017

The multiple facets of glucocorticoid action in rheumatoid arthritis (English)

1 reference

27 August 2017

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Ulrike Baschant

1

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27 August 2017

Nancy E Lane

series ordinal

2

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27 August 2017

Jan Tuckermann

series ordinal

3

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27 August 2017

language of work or name

English

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publication date

9 October 2012

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Nature Reviews Rheumatology

27 August 2017

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27 August 2017

8

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27 August 2017

645-655

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27 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2012.166

27 August 2017

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Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial

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Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial

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Effects of low-dose prednisone on bone metabolism

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Use of oral corticosteroids and risk of fractures.

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Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: An investigator-initiated, multicenter, randomized, double-blind

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Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats

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A defect in cortisol production in rheumatoid arthritis: why are we still looking?

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11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice

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Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo.

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Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

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Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists

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Steroid hormone receptors: many actors in search of a plot

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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

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Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.

21 January 2018

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Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding

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Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.

21 January 2018

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Glucocorticoid receptor mutants: man-made tools for functional research

21 January 2018

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Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

21 January 2018

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Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor

21 January 2018

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DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

21 January 2018

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The role of the glucocorticoid receptor in inflammation and immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

New and improved glucocorticoid receptor ligands

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Targeting inflammation using selective glucocorticoid receptor modulators

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The antagonists but not partial agonists of glucocorticoid receptor ligands show substantial side effect dissociation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

DNA binding of the glucocorticoid receptor is not essential for survival

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase

21 January 2018

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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

21 January 2018

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Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Cells of the synovium in rheumatoid arthritis. T lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The pathogenesis of rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Utility of animal models for identification of potential therapeutics for rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Regulatory T cells protect from local and systemic bone destruction in arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Cells of the synovium in rheumatoid arthritis. B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The changing preference of T and B cells for partners as T-dependent antibody responses develop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Differential effects of corticosteroids during different stages of dendritic cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Cytokines in the pathogenesis of rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Influence of bisphosphonates on the production of pro-inflammatory cytokines by activated human articular chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid-induced osteoporosis: pathophysiology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids suppress bone formation via the osteoclast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid dose determines osteocyte cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Matrix-embedded cells control osteoclast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The role of Dickkopf-1 in bone development, homeostasis, and disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids down-regulate dendritic cell functionin vitro andin vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Organ-specific disease provoked by systemic autoimmunity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoid-induced apoptosis in early B cells from human bone marrow.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids inhibit dendritic cell maturation induced by Toll-like receptor 7 and Toll-like receptor 8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids increase the endocytic activity of human dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

NF-kappaB: Holy Grail for rheumatoid arthritis?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.166

DNA-dependent cofactor selectivity of the glucocorticoid receptor

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23045254

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The discovery and early use of cortisone.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23045254

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2012.166

1 reference

Dimensions Publication ID

27 August 2017

0 references

1 reference