Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases (Q38053052)

27 August 2017

title

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases (English)

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27 August 2017

Kenneth Verstraete

1

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author name string

Savvas N Savvides

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

18 October 2012

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27 August 2017

published in

Nature Reviews Cancer

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27 August 2017

volume

12

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27 August 2017

issue

11

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27 August 2017

page(s)

753-766

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The protein tyrosine kinase family of the human genome

27 August 2017

cites work

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FLT3 as a therapeutic target in AML: still challenging after all these years

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Structure of a c-kit product complex reveals the basis for kinase transactivation

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FMS Kinase Inhibitors: Current Status and Future Prospects.

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Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia

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Targeting cancer with small molecule kinase inhibitors

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Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells

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Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

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The biology of stem cell factor and its receptor C-kit

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Structural basis for stem cell factor–KIT signaling and activation of class III receptor tyrosine kinases

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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

31 March 2020

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Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

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Kit receptor dimerization is driven by bivalent binding of stem cell factor

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Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

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Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

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IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.

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Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

31 March 2020

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Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

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Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R

31 March 2020

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The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1

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Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases

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Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival

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Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow.

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The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

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Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

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Flt-3 ligand: a potent dendritic cell stimulator and novel antitumor agent

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Development of dendritic-cell lineages

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Identification and characterization of a functional murine FLT3 isoform produced by exon skipping

31 March 2020

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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

31 March 2020

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Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

31 March 2020

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Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

31 March 2020

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Functional importance of platelet-derived growth factor (PDGF) receptor extracellular immunoglobulin-like domains. Identification of PDGF binding site and neutralizing monoclonal antibodies

31 March 2020

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Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen

31 March 2020

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A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

31 March 2020

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Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

31 March 2020

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Receptor tyrosine kinase transmembrane domains: Function, dimer structure and dimerization energetics

31 March 2020

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Structure elucidation of dimeric transmembrane domains of bitopic proteins

31 March 2020

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The strong dimerization of the transmembrane domain of the fibroblast growth factor receptor (FGFR) is modulated by C-terminal juxtamembrane residues

31 March 2020

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High-throughput selection of transmembrane sequences that enhance receptor tyrosine kinase activation

31 March 2020

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Hydrophobic Matching Controls the Tilt and Stability of the Dimeric Platelet-derived Growth Factor Receptor (PDGFR) Transmembrane Segment

31 March 2020

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Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions

31 March 2020

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Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase

31 March 2020

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Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers

31 March 2020

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Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies

31 March 2020

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A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

31 March 2020

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family

31 March 2020

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The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain

31 March 2020

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Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

31 March 2020

1 reference

Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance

31 March 2020

1 reference

Phosphorylation in the activation loop as the finishing touch in c-Kit activation

31 March 2020

1 reference

A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation

31 March 2020

1 reference

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

31 March 2020

1 reference

Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.

31 March 2020

1 reference

Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events

31 March 2020

1 reference

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

31 March 2020

1 reference

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

31 March 2020

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Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor beta-receptor (beta-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases

31 March 2020

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Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

31 March 2020

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Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816

31 March 2020

1 reference

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

31 March 2020

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Spatial regulation of receptor tyrosine kinases in development and cancer

31 March 2020

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Targeted therapy in GIST: in silico modeling for prediction of resistance

31 March 2020

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The origin and evolution of mutations in acute myeloid leukemia

31 March 2020

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From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets

31 March 2020

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Passenger deletions generate therapeutic vulnerabilities in cancer

31 March 2020

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

31 March 2020

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Further activation of FLT3 mutants by FLT3 ligand

31 March 2020

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Rethinking bioactivity of FLT3 inhibitors

31 March 2020

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Regulation of the catalytic activity of the EGF receptor.

31 March 2020

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FLT3 inhibitors in the treatment of acute myeloid leukemia: the start of an era?

31 March 2020

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Emerging FMS-like tyrosine kinase 3 inhibitors for the treatment of acute myelogenous leukemia

31 March 2020

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c-FMS inhibitors: a patent review

31 March 2020

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Colony-stimulating factor-1 receptor inhibitors for the treatment of cancer and inflammatory disease

31 March 2020

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31 March 2020

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Developments in targeted therapy of advanced gastrointestinal stromal tumors.

31 March 2020

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31 March 2020

KIT mutations in GIST.

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Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review).

31 March 2020

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FLT3/ITD AML and the law of unintended consequences

31 March 2020

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FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo

31 March 2020

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Targeting FMS-related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC-EB10.

31 March 2020

1 reference

Monoclonal antibody-based therapeutics for leukemia

31 March 2020

1 reference

Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibody

31 March 2020

1 reference

Cell-based selection of internalizing fully human antagonistic antibodies directed against FLT3 for suppression of leukemia cell growth

31 March 2020

1 reference

Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia

31 March 2020

1 reference

Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling.

31 March 2020

1 reference

Anti-human FLT3 monoclonal antibody that inhibits proliferation of monocytic leukemia cell line SHI-1.

31 March 2020

1 reference

Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha.

31 March 2020

1 reference

Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody

31 March 2020

1 reference

Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume.

31 March 2020

1 reference

Development trends for human monoclonal antibody therapeutics

31 March 2020

1 reference

Monoclonal antibodies: versatile platforms for cancer immunotherapy

31 March 2020

1 reference

Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts

31 March 2020

1 reference

Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells

31 March 2020

1 reference

Anti‐PDGF‐B monoclonal antibody reduces liver fibrosis development

31 March 2020

1 reference

Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

31 March 2020

1 reference

Surface binding inhibitors of the SCF-KIT protein-protein interaction.

31 March 2020

1 reference

Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain

31 March 2020

1 reference

Protein-protein interaction inhibitors get into the groove

31 March 2020

1 reference

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

31 March 2020

1 reference

An Antibody Reactive with Domain 4 of the Platelet-derived Growth Factor β Receptor Allows BB Binding while Inhibiting Proliferation by Impairing Receptor Dimerization

31 March 2020

1 reference

Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization

31 March 2020

1 reference

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor

31 March 2020

1 reference

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

31 March 2020

1 reference

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

31 March 2020

1 reference

Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains

31 March 2020

1 reference

The immunoglobulin superfamily: an insight on its tissular, species, and functional diversity

31 March 2020

1 reference

Genomic structure of human FLT3: implications for mutational analysis

31 March 2020

1 reference

Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor

31 March 2020

1 reference

31 March 2020

Cancer statistics, 2012

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Structural and functional alterations of FLT3 in acute myeloid leukemia

31 March 2020

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FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

31 March 2020

1 reference

The GIST paradigm: lessons for other kinase-driven cancers

31 March 2020

1 reference

Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia.

31 March 2020

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Stem cell factor and its receptor c-Kit as targets for inflammatory diseases

31 March 2020

1 reference

FMS mutations in myelodysplastic, leukemic, and normal subjects

31 March 2020

1 reference

CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas

31 March 2020

1 reference

The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update

31 March 2020

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31 March 2020

12 December 2020

Elevated expression of the oncogene c-fms and its ligand, the macrophage colony-stimulating factor-1, in cervical cancer and the role of transforming growth factor-beta1 in inducing c-fms expression

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Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth

31 March 2020

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Oncogenic derivatives of platelet-derived growth factor receptors.

31 March 2020

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PDGF receptors as cancer drug targets

31 March 2020

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PDGF receptors as targets in tumor treatment

31 March 2020

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Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.

31 March 2020

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Structural determinants of growth factor binding and specificity by VEGF receptor 2

31 March 2020

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Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

31 March 2020

1 reference

Structure of a VEGF-VEGF receptor complex determined by electron microscopy

31 March 2020

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Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor

31 March 2020

1 reference

Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation

31 March 2020

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Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit

31 March 2020

1 reference

The majority of stem cell factor exists as monomer under physiological conditions. Implications for dimerization mediating biological activity

31 March 2020

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The PDGF family: four gene products form five dimeric isoforms

31 March 2020

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Overview of the CCP4 suite and current developments

31 March 2020

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D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias

31 March 2020

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Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate

31 March 2020

1 reference

Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.

31 March 2020

1 reference

Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.

31 March 2020

1 reference

Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

31 March 2020

1 reference

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

31 March 2020

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Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.

31 March 2020

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12 December 2020

Receptor tyrosine kinase transmembrane domain interactions: potential target for "interceptor" therapy

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12 December 2020

c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities

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12 December 2020

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma.

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12 December 2020

The single transmembrane domains of human receptor tyrosine kinases encode self-interactions

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12 December 2020

Increasing bioactivity of Flt3 ligand by fusing two identical soluble domains

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12 December 2020

Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response

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12 December 2020

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor

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12 December 2020

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor

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Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

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12 December 2020

In vivo analysis of dendritic cell development and homeostasis

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12 December 2020

Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor

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12 December 2020

Crystal structure of human platelet-derived growth factor BB

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12 December 2020

A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain

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12 December 2020

Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis

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12 December 2020

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family

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12 December 2020

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase

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12 December 2020

c-fms point mutations in acute myeloid leukemia: fact or fiction?

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12 December 2020

Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis

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12 December 2020

Soluble kit receptor in human serum.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3371

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Dimensions Publication ID

27 August 2017

1029924656

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