The role of promoter hypermethylation in fibroblast activation and fibrogenesis (Q38055432)

27 August 2017

The role of promoter hypermethylation in fibroblast activation and fibrogenesis (English)

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Collaborative Research Centre (CRC) 1002: "Modulatory Units in Heart Failure"

27 August 2017

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Elisabeth M Zeisberg

1

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PubMed ID

23097091

27 August 2017

Michael Zeisberg

series ordinal

2

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27 August 2017

1 January 2013

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27 August 2017

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27 August 2017

229

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27 August 2017

264-273

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27 August 2017

2

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Renal fibroblasts and myofibroblasts in chronic kidney disease

27 August 2017

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21 January 2018

Fibroblasts in cancer

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Renal fibrosis: an update

21 January 2018

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Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines

21 January 2018

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Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

21 January 2018

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The discoidin domain receptor tyrosine kinases are activated by collagen

21 January 2018

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Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation

21 January 2018

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Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1.

21 January 2018

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Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.

21 January 2018

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Pathophysiology of AKI: injury and normal and abnormal repair

21 January 2018

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Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

21 January 2018

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Methylation determines fibroblast activation and fibrogenesis in the kidney

21 January 2018

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Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis.

21 January 2018

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The myofibroblast: one function, multiple origins

21 January 2018

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Targeting fibrosis in systemic sclerosis

21 January 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

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21 January 2018

The mammalian epigenome

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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Molecular control of pluripotency

21 January 2018

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Methylation-induced repression--belts, braces, and chromatin

21 January 2018

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Dissecting DNA hypermethylation in cancer.

21 January 2018

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

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Cytosine methylation and the ecology of intragenomic parasites

21 January 2018

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Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

21 January 2018

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Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research

21 January 2018

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Gene body-specific methylation on the active X chromosome

21 January 2018

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Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

21 January 2018

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Conserved role of intragenic DNA methylation in regulating alternative promoters

21 January 2018

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

21 January 2018

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The Roles of the Methyl-CpG Binding Proteins in Cancer

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

21 January 2018

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

21 January 2018

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Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer

21 January 2018

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SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein

21 January 2018

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Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth

21 January 2018

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

21 January 2018

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

21 January 2018

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

21 January 2018

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A family of human zinc finger proteins that bind methylated DNA and repress transcription

21 January 2018

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CpG island methylator phenotype in colorectal cancer

21 January 2018

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Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

21 January 2018

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A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

21 January 2018

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MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats

21 January 2018

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Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.

21 January 2018

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Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

21 January 2018

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DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

21 January 2018

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MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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PTEN/MMAC1 mutations in hepatocellular carcinomas.

21 January 2018

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Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer

21 January 2018

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Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.

21 January 2018

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Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas

21 January 2018

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Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas

21 January 2018

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An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function

21 January 2018

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In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases

21 January 2018

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Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells

21 January 2018

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De novo CpG island methylation in human cancer cells

21 January 2018

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Identification of preferential target sites for human DNA methyltransferases

21 January 2018

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Predicting aberrant CpG island methylation

21 January 2018

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Optimizing hypomethylating agents in myelodysplastic syndromes

21 January 2018

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Mutation in TET2 in myeloid cancers

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

21 January 2018

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

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DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes

21 January 2018

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Epigenetic drug discovery: targeting DNA methyltransferases

21 January 2018

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Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives

21 January 2018

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Concise review: Deciphering the mechanism behind induced pluripotent stem cell generation

21 January 2018

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DNA demethylation dynamics

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

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Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

21 January 2018

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Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease.

21 January 2018

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Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?

21 January 2018

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Multigenerational epigenetic adaptation of the hepatic wound-healing response

21 January 2018

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Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

21 January 2018

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Hypermethylation-mediated silencing of p14(ARF) in fibroblasts from idiopathic pulmonary fibrosis.

21 January 2018

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Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis

21 January 2018

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Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation

21 January 2018

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Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4120

1 reference

27 August 2017

1 reference

PubMed ID

23097091