Structural basis of innate immune recognition of viral RNA. (Q38056521)

27 August 2017

Structural basis of innate immune recognition of viral RNA. (English)

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27 August 2017

Yorgo Modis

3

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author name string

Ian C Berke

series ordinal

1

1 reference

PubMed ID

23110455

27 August 2017

Yue Li

series ordinal

2

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27 August 2017

21 November 2012

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27 August 2017

Cellular Microbiology

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27 August 2017

15

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27 August 2017

3

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27 August 2017

386-394

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

27 August 2017

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Pathogen recognition and innate immunity

21 January 2018

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

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Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2

21 January 2018

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

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The molecular structure of the Toll-like receptor 3 ligand-binding domain.

21 January 2018

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MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

21 January 2018

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MDA5 assembles into a polar helical filament on dsRNA.

21 January 2018

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Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

21 January 2018

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

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The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

21 January 2018

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The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

21 January 2018

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The 'complexities' of life and death: death receptor signalling platforms

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

21 January 2018

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Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily

21 January 2018

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Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

21 January 2018

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What the Myddosome structure tells us about the initiation of innate immunity

21 January 2018

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Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity

21 January 2018

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Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling

21 January 2018

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

21 January 2018

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

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5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

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MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

21 January 2018

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Innate immune recognition

21 January 2018

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Structural basis of RNA recognition and activation by innate immune receptor RIG-I

21 January 2018

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Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

21 January 2018

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55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation

21 January 2018

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

21 January 2018

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Toll-like receptor and RIG-I-like receptor signaling

21 January 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

21 January 2018

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

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The TLR3 signaling complex forms by cooperative receptor dimerization

21 January 2018

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Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

21 January 2018

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DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

21 January 2018

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

21 January 2018

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The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

21 January 2018

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

21 January 2018

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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

21 January 2018

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Structural Insights into RNA Recognition by RIG-I

21 January 2018

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Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure

21 January 2018

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Molecular cell death platforms and assemblies

21 January 2018

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Subcellular localization of Toll-like receptor 3 in human dendritic cells

21 January 2018

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TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements

21 January 2018

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Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity

21 January 2018

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

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Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

21 January 2018

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Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

21 January 2018

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Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

21 January 2018

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

21 January 2018

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Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization

21 January 2018

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A molecular view on signal transduction by the apoptosome

21 January 2018

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Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

21 January 2018

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

21 January 2018

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Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

21 January 2018

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Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors

21 January 2018

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MAVS self-association mediates antiviral innate immune signaling

21 January 2018

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

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Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/CMI.12061

1 reference

27 August 2017

1 reference

PubMed ID

23110455