The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. (Q38059682)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150273%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation (English)

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17 February 2020

2

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17 February 2020

author name string

Rebekah R Bartelt

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150273%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

language of work or name

1 reference

13 November 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150273%20AND%20SRC:MED&resulttype=core&format=json

Wiley interdisciplinary reviews. Systems biology and medicine

17 February 2020

published in

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17 February 2020

volume

5

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17 February 2020

issue

1

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17 February 2020

page(s)

101-110

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Deconstructing Ras signaling in the thymus

17 February 2020

cites work

1 reference

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Role of LAT in the granule-mediated cytotoxicity of CD8 T cells

6 September 2017

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Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

6 September 2017

1 reference

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Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells

6 September 2017

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Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses

6 September 2017

1 reference

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Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

6 September 2017

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Lipid Signaling in T-Cell Development and Function

6 September 2017

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Multiple pathways leading from the T‐cell antigen receptor to the actin cytoskeleton network

6 September 2017

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Mediation of T-cell activation by actin meshworks

6 September 2017

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Cooperative interactions at the SLP-76 complex are critical for actin polymerization

6 September 2017

1 reference

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T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering

6 September 2017

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Molecular mechanisms in signal transduction at the membrane

6 September 2017

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Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76

6 September 2017

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The role of the LAT-PLC-gamma1 interaction in T regulatory cell function

6 September 2017

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The NF-kappaB family of transcription factors and its regulation

6 September 2017

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

6 September 2017

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Endocytic events in TCR signaling: focus on adapters in microclusters

6 September 2017

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Calcium signaling in the development and function of T-lineage cells

6 September 2017

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The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

6 September 2017

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

6 September 2017

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Digital signaling and hysteresis characterize ras activation in lymphoid cells

6 September 2017

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6 September 2017

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CD4 T cells: fates, functions, and faults

6 September 2017

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c-Cbl-mediated regulation of LAT-nucleated signaling complexes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Regulation of T-cell activation by the cytoskeleton

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Persistence of cooperatively stabilized signaling clusters drives T-cell activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

6 September 2017

1 reference

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MAP kinases in immune responses.

6 September 2017

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Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways

6 September 2017

1 reference

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

6 September 2017

1 reference

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NFAT proteins: key regulators of T-cell development and function

6 September 2017

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Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

6 September 2017

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Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells

6 September 2017

1 reference

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

6 September 2017

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Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

6 September 2017

1 reference

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Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development

6 September 2017

1 reference

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Solution structure of Grb2 reveals extensive flexibility necessary for target recognition

6 September 2017

1 reference

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Essential role of LAT in T cell development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Identification of a ten-amino acid proline-rich SH3 binding site

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Differential interactions of human Sos1 and Sos2 with Grb2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

LAT regulates gammadelta T cell homeostasis and differentiation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Identification of the minimal tyrosine residues required for linker for activation of T cell function

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883108

CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23150273

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/WSBM.1194

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150273%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150273%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23150273

1 reference