Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling. (Q38059809)

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17 February 2020

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Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling (English)

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29 October 2020

Vijayakumar Gosu

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17 February 2020

Shaherin Basith

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17 February 2020

O-Pil Kwon

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17 February 2020

Sangdun Choi

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17 February 2020

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English

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publication date

14 November 2012

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3 November 2020

6 references

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17 February 2020

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11

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17 February 2020

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Creative Commons Attribution 3.0 Unported

17 February 2020

copyright license

5 references

26 August 2020

14 September 2020

27 October 2020

29 October 2020

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

3 November 2020

0 references

1 reference

12 December 2020

An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles

1 reference

12 December 2020

A review of clinical studies of bropirimine immunotherapy of carcinoma in situ of the bladder and upper urinary tract

1 reference

12 December 2020

Synthetic agonists of Toll-like receptors 7, 8 and 9.

1 reference

12 December 2020

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

12 December 2020

Vaccine adjuvants: scientific challenges and strategic initiatives

1 reference

12 December 2020

A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome

1 reference

12 December 2020

Imiquimod applied topically: a novel immune response modifier and new class of drug

1 reference

12 December 2020

Dual or triple activation of TLR7, TLR8, and/or TLR9 by single-stranded oligoribonucleotides

1 reference

12 December 2020

1 reference

12 December 2020

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

1 reference

12 December 2020

Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination

1 reference

12 December 2020

A role for Toll in autoimmunity

1 reference

12 December 2020

Plant and animal sensors of conserved microbial signatures

1 reference

12 December 2020

TLR7 and TLR8 as targets in cancer therapy

1 reference

12 December 2020

A Toll-like receptor recognizes bacterial DNA

1 reference

12 December 2020

Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis

1 reference

12 December 2020

Augmented antitumor effect of combined human natural interferon-alpha and mismatched double-stranded RNA treatment against a human malignant melanoma xenograft

1 reference

12 December 2020

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

1 reference

12 December 2020

Innate immune recognition

1 reference

12 December 2020

Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

1 reference

12 December 2020

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

1 reference

12 December 2020

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

1 reference

12 December 2020

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

1 reference

12 December 2020

The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu

1 reference

12 December 2020

Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12.

1 reference

12 December 2020

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

1 reference

12 December 2020

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

1 reference

12 December 2020

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

1 reference

12 December 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

1 reference

12 December 2020

Strategies for targeting T-cells in allergic diseases and asthma

1 reference

12 December 2020

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

1 reference

12 December 2020

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

1 reference

12 December 2020

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

1 reference

12 December 2020

Recognition of single-stranded RNA viruses by Toll-like receptor 7

1 reference

12 December 2020

Features of systemic lupus erythematosus in Dnase1-deficient mice

1 reference

12 December 2020

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

1 reference

12 December 2020

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

12 December 2020

Subcellular localization of Toll-like receptor 3 in human dendritic cells

1 reference

12 December 2020

Therapeutic potential of Toll-like receptor 9 activation

1 reference

12 December 2020

Mutation of DNASE1 in people with systemic lupus erythematosus

1 reference

12 December 2020

Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease.

1 reference

12 December 2020

Signaling pathways downstream of pattern-recognition receptors and their cross talk

1 reference

12 December 2020

TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production

1 reference

12 December 2020

Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

1 reference

12 December 2020

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses

1 reference

12 December 2020

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

1 reference

12 December 2020

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

1 reference

12 December 2020

Antimicrobial peptides of multicellular organisms

1 reference

12 December 2020

Cytokine induction by the immunomodulators imiquimod and S-27609

1 reference

12 December 2020

7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine

1 reference

12 December 2020

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

1 reference

12 December 2020

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

1 reference

12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

12 December 2020

TLR signaling pathways

1 reference

12 December 2020

Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy

1 reference

12 December 2020

Toll-like receptor function and signaling

1 reference

12 December 2020

Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod

1 reference

12 December 2020

Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer

1 reference

12 December 2020

Emerging drugs for the treatment of ulcerative colitis

1 reference

12 December 2020

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

1 reference

12 December 2020

An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma

1 reference

12 December 2020

Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides

1 reference

12 December 2020

Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators

1 reference

12 December 2020

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

1 reference

12 December 2020

Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands

1 reference

12 December 2020

CpG motifs in bacterial DNA trigger direct B-cell activation

1 reference

12 December 2020

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

12 December 2020

Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia

1 reference

12 December 2020

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

1 reference

12 December 2020

Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy.

1 reference

12 December 2020

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation

1 reference

12 December 2020

TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements

1 reference

12 December 2020

Pathogen recognition and innate immunity

1 reference

12 December 2020

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

1 reference

12 December 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

12 December 2020

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

1 reference

12 December 2020

Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages

1 reference

12 December 2020

Cathepsins are required for Toll-like receptor 9 responses

1 reference

12 December 2020

The roles of TLRs, RLRs and NLRs in pathogen recognition

1 reference

12 December 2020

In silico approach to inhibition of signaling pathways of Toll-like receptors 2 and 4 by ST2L

1 reference

12 December 2020

Pathogen recognition with Toll-like receptors

1 reference

12 December 2020

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

1 reference

12 December 2020

A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro.

1 reference

12 December 2020

The Yaa gene model of systemic lupus erythematosus

1 reference

12 December 2020

TLR8 deficiency leads to autoimmunity in mice

1 reference

12 December 2020

How Toll-like receptors signal: what we know and what we don't know

1 reference

12 December 2020

TLR3 can directly trigger apoptosis in human cancer cells.

1 reference

12 December 2020

Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment

1 reference

12 December 2020

Toll-like receptor signal transduction

1 reference

12 December 2020

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

1 reference

12 December 2020

Physiological and molecular mechanisms of lymphocyte homing

1 reference

12 December 2020

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

1 reference

12 December 2020

Activation of autoreactive B cells by CpG dsDNA

1 reference

12 December 2020

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

1 reference

12 December 2020

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

1 reference

12 December 2020

Roles of toll-like receptors in cancer: a double-edged sword for defense and offense

1 reference

12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

12 December 2020

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

1 reference

12 December 2020

In vitro antitumor activity of bropirimine against urinary bladder tumor cells.

1 reference

12 December 2020

The antiviral activity of Toll-like receptor 7 and 7/8 agonists

1 reference

12 December 2020

Structure of a complex of tandem HMG boxes and DNA.

1 reference

12 December 2020

Regulation of phagosome maturation by signals from toll-like receptors.

1 reference

12 December 2020

Inflammation and cancer: back to Virchow?

1 reference

12 December 2020

A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates

1 reference

12 December 2020

Cytokine induction in mice by the immunomodulator imiquimod.

1 reference

12 December 2020

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

1 reference

12 December 2020

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

1 reference

12 December 2020

Herpes simplex virus encephalitis in human UNC-93B deficiency

1 reference

12 December 2020

Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: a 14 year follow-up analysis of a randomized trial of the Fédération Nationale des Centres de Lutte contre le Cancer (FNCLCC)

1 reference

12 December 2020

Immunobiology of Toll-like receptors: emerging trends

1 reference

12 December 2020

Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists

1 reference

12 December 2020

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

1 reference

12 December 2020

Current and future treatment options for HCV.

1 reference

12 December 2020

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

1 reference

12 December 2020

Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

1 reference

12 December 2020

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.

1 reference

12 December 2020

The future of toll-like receptor therapeutics.

1 reference

12 December 2020

Toll-like receptors and cancer

1 reference

12 December 2020

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

1 reference

12 December 2020

The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.

1 reference

12 December 2020

An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma

1 reference

12 December 2020

Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization

1 reference

12 December 2020

Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in Toll-like receptor signaling

1 reference

12 December 2020

Polyadenylic-polyuridylic acid as an adjuvant in resectable colorectal carcinoma: a 6 1/2 year follow-up analysis of a multicentric double blind randomized trial.

1 reference

12 December 2020

Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.

1 reference

12 December 2020

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1 reference

12 December 2020

Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A:U) for locally advanced gastric cancer after curative surgery: final results of 15-year follow-up

1 reference

12 December 2020

Phase 1 trial of a CpG oligodeoxynucleotide for patients with recurrent glioblastoma

1 reference

12 December 2020

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

1 reference

12 December 2020

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

1 reference

12 December 2020

TLR3 deficiency in patients with herpes simplex encephalitis

1 reference

12 December 2020

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

12 December 2020

Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

1 reference

12 December 2020

Serum interferon levels in patients with systemic lupus erythematosus

1 reference

12 December 2020

Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7

1 reference

12 December 2020

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

1 reference

12 December 2020

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1 reference

12 December 2020

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

1 reference

12 December 2020

Targeting Toll-like receptors: emerging therapeutics?

1 reference

12 December 2020

Comparative studies of ampligen (mismatched double-stranded RNA) and interferons

1 reference

12 December 2020

Toll-like receptors: applications to dermatologic disease

1 reference

12 December 2020

EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice

1 reference

12 December 2020

Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus

1 reference

12 December 2020

Therapeutic applications of nucleic acids as ligands for Toll-like receptors

1 reference

12 December 2020

Drugs targeting Toll-like receptors

1 reference

12 December 2020

Regulation of adaptive immunity by the innate immune system

1 reference

12 December 2020

Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies

1 reference

12 December 2020

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders

1 reference

12 December 2020

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

1 reference

12 December 2020

Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells

1 reference

12 December 2020

Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463

1 reference

12 December 2020

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

12 December 2020

RNA recognition and signal transduction by RIG-I-like receptors

1 reference

12 December 2020

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

1 reference

12 December 2020

Review Article Imiquimod applied topically: a novel immune response modifier and new class of drug

1 reference

12 December 2020

10.3390/MOLECULES171113503

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23151919%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

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17 February 2020

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