The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs (Q38071690)

28 August 2017

1 reference

title

The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs (English)

1 reference

28 August 2017

1 reference

Yan Li

1

1 reference

PubMed ID

23289831

28 August 2017

James W Paxton

series ordinal

2

1 reference

PubMed ID

23289831

28 August 2017

language of work or name

English

0 references

publication date

6 January 2013

1 reference

Expert Opinion on Drug Metabolism & Toxicology

28 August 2017

1 reference

28 August 2017

9

1 reference

28 August 2017

267-285

1 reference

28 August 2017

3

1 reference

Cancer chemoprevention with dietary phytochemicals

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Neuroprotection by bioactive components in medicinal and food plant extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Interactions of herbs with cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Dietary flavonoids: effects on xenobiotic and carcinogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Drug transport proteins in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Transporters as a determinant of drug clearance and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Targeting multidrug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoids as antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Advances in flavonoid research since 1992.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The biochemistry and medical significance of the flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Metabolism of flavonoids via enteric recycling: role of intestinal disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Biotransformation of green tea polyphenols and the biological activities of those metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Tea and cancer prevention: molecular mechanisms and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Intestinal and hepatic glucuronidation of flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Morphine-6-glucuronide: an analgesic of the future?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

ABC transporters: the power to change

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The ABC transporter structure and mechanism: perspectives on recent research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The ATP switch model for ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoid-drug interactions: effects of flavonoids on ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Protein kinases and multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of bioflavonoids on vincristine transport across blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

ABCG2 -- a transporter for all seasons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Interaction of the breast cancer resistance protein with plant polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Interactions of cyclosporin a with breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Multidrug resistance-associated proteins 3, 4, and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

On the putative co-transport of drugs by multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Multiple flavonoid-binding sites within multidrug resistance protein MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of flavonoids on MRP1-mediated transport in Panc-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

MRP2 and 3 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

MDR- and CYP3A4-mediated drug-herbal interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Lethal quercetin-digoxin interaction in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Fruit juice inhibition of uptake transport: a new type of food-drug interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Breast cancer resistance protein exports sulfated estrogens but not free estrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Grapefruit juice ingestion significantly reduces talinolol bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

The effects of fruit juices on drug disposition: a new model for drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Effect of fruit juices on the oral bioavailability of fexofenadine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.749858

10.1517/17425255.2013.749858

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23289831