Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior (Q37514340)

20 August 2017

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title

Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior (English)

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20 August 2017

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Lesley A Stanley

1

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20 August 2017

Brian C Horsburgh

2

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20 August 2017

Jillian Ross

3

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20 August 2017

Nico Scheer

4

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20 August 2017

C Roland Wolf

5

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20 August 2017

language of work or name

English

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publication date

1 January 2009

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20 August 2017

published in

Drug Metabolism Reviews

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20 August 2017

volume

41

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20 August 2017

issue

1

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20 August 2017

page(s)

27-65

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Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Brain permeability of inhaled corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein-based drug-drug interactions: preclinical methods and relevance to clinical observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Evaluation of the utility of brain slice methods to study brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

High throughput artificial membrane permeability assay for blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The role of transporters in drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

mdr1a deficiency corrects sterility in Niemann-Pick C1 protein deficient female mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Drug transport proteins in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Brain cyclosporin A levels are determined by ontogenic regulation of mdr1a expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Transporters and xenobiotic disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Hyperosmotic mannitol activates basolateral NHE in proximal tubule from P-glycoprotein null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

New functional assay of P-glycoprotein activity using Hoechst 33342.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Differential involvement of multidrug resistance-associated protein 1 and P-glycoprotein in tissue distribution and excretion of grepafloxacin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

The physiological function of drug-transporting P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Multidrug resistance and the role of P-glycoprotein knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Fumonisin toxicity in a transgenic mouse model lacking the mdr1a/1b P-glycoprotein genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Prediction of human intestinal permeability using artificial membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Drug efflux transporters in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

Flow cytometric analysis of P-glycoprotein function using rhodamine 123

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530802605040

10.1080/03602530802605040

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference