T cells out of control--impaired immune regulation in the inflamed joint (Q38079816)

28 August 2017

T cells out of control--impaired immune regulation in the inflamed joint (English)

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28 August 2017

Ellen J Wehrens

1

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28 August 2017

Berent J Prakken

series ordinal

2

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28 August 2017

Femke van Wijk

series ordinal

3

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28 August 2017

language of work or name

English

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publication date

1 January 2013

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Nature Reviews Rheumatology

28 August 2017

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28 August 2017

9

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28 August 2017

34-42

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28 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2012.149

28 August 2017

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cites work

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The yin and yang of regulatory T cells and inflammation in RA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Cytokines in the pathogenesis of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The role of T cells in rheumatoid arthritis: new subsets and new targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Cells of the synovium in rheumatoid arthritis. T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

IL-17 as a future therapeutic target for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Profiling of CD4+ T cells with epigenetic immune lineage analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Epigenetic control of T-helper-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Rheumatoid arthritis synovium contains plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Regulatory T cells as therapeutic targets in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Inhibition of human CD4(+)CD25(+high) regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Rescuing CD4+CD25+ regulatory T-cell functions in rheumatoid arthritis by cytokine-targeted monoclonal antibody therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

IL-17-producing human peripheral regulatory T cells retain suppressive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Late developmental plasticity in the T helper 17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

IL-17 induces monocyte migration in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Anti-TNFα discontinuation in rheumatoid and psoriatic arthritis: is it possible after disease remission?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Differentiation of Inflammatory Dendritic Cells Is Mediated by NF- B1-Dependent GM-CSF Production in CD4 T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Distribution and clinical significance of blood dendritic cells in children with juvenile idiopathic arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Proinflammatory mediator–induced reversal of CD4+,CD25+ regulatory T cell–mediated suppression in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

alpha1beta1 Integrin+ and regulatory Foxp3+ T cells constitute two functionally distinct human CD4+ T cell subsets oppositely modulated by TNFalpha blockade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

TRAIL is associated with impaired regulation of CD4+CD25- T cells by regulatory T cells in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Phenotypic and functional features of human Th17 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.149

The inhibitory pathway PD-1/PD-1 ligands is upregulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis

31 March 2020

1 reference

12 December 2020

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium

1 reference

12 December 2020

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2012.149

1 reference

Dimensions Publication ID

28 August 2017

0 references

1 reference