The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors (Q37018786)

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18 January 2020

title

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors (English)

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18 January 2020

1

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18 January 2020

Vincent C Auyeung

2

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18 January 2020

author name string

Markus Feuerer

3

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18 January 2020

Junko Nishio

4

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18 January 2020

Jason Fontenot

5

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18 January 2020

Christophe Benoist

6

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18 January 2020

Diane Mathis

7

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18 January 2020

language of work or name

English

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publication date

10 December 2008

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Proceedings of the National Academy of Sciences of the United States of America

18 January 2020

published in

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18 January 2020

volume

105

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18 January 2020

page(s)

19857-19862

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18 January 2020

issue

50

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The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

18 January 2020

cites work

1 reference

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Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

29 September 2017

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

29 September 2017

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Role of Foxp3-positive regulatory T cells during infection

29 September 2017

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Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

29 September 2017

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Foxp3 in control of the regulatory T cell lineage

29 September 2017

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The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice

29 September 2017

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Regulatory T cells and cancer

29 September 2017

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

29 September 2017

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

29 September 2017

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29 September 2017

FOXP3: of mice and men.

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Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

29 September 2017

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

29 September 2017

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

29 September 2017

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Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

29 September 2017

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A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

29 September 2017

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

29 September 2017

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The NOD mouse: a model of immune dysregulation

29 September 2017

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

29 September 2017

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Tolerance, not immunity, crucially depends on IL-2.

29 September 2017

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

29 September 2017

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

29 September 2017

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

29 September 2017

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Aire regulates negative selection of organ-specific T cells

29 September 2017

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Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice

29 September 2017

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Multiple immuno-regulatory defects in type-1 diabetes

29 September 2017

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

29 September 2017

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Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

29 September 2017

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

29 September 2017

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Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

29 September 2017

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Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

4 September 2018

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Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells.

4 September 2018

1 reference

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Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.

4 September 2018

1 reference

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Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

4 September 2018

1 reference

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Comment on: Tritt et al. (2007) Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes: Diabetes 57:113-123, 2007

4 September 2018

1 reference

12 December 2020

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms

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12 December 2020

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

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12 December 2020

A defect in central tolerance in NOD mice

1 reference

12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

1 reference

12 December 2020

MHC-linked protection from diabetes dissociated from clonal deletion of T cells

1 reference

12 December 2020

Following a diabetogenic T cell from genesis through pathogenesis

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12 December 2020

CD4+CD25high regulatory T cells in human autoimmune diabetes

1 reference

12 December 2020

Defective central tolerance induction in NOD mice: genomics and genetics

1 reference

12 December 2020

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

12 December 2020

IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0810713105

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18 January 2020

0 references

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18 January 2020

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