Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein (Q38080804)

28 August 2017

title

Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein (English)

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28 August 2017

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1

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28 August 2017

2

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28 August 2017

7

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28 August 2017

Rosaria Lupica

3

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28 August 2017

Antoine Buemi

4

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28 August 2017

Domenico Trimboli

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28 August 2017

Grazia Giorgianni

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28 August 2017

Michele Buemi

8

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28 August 2017

language of work or name

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11 February 2013

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Medicinal Research Reviews

28 August 2017

published in

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28 August 2017

volume

34

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28 August 2017

issue

1

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28 August 2017

page(s)

77-105

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The minimal active structure of human relaxin-2

28 August 2017

cites work

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Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics.

21 January 2018

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Membrane receptors: structure and function of the relaxin family peptide receptors

21 January 2018

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Activation of orphan receptors by the hormone relaxin

21 January 2018

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INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent

21 January 2018

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Relaxin-3 systems in the brain--the first 10 years.

21 January 2018

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Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.

21 January 2018

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Relaxin favors the development of activated human T cells into Th1-like effectors

21 January 2018

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Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis

21 January 2018

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Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat.

21 January 2018

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Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis

21 January 2018

1 reference

Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element.

21 January 2018

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Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth

21 January 2018

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Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase

21 January 2018

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Insulin-like peptide 6: characterization of secretory status and posttranslational modifications.

21 January 2018

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Relaxin and Collagen Metabolism

21 January 2018

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Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats

21 January 2018

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Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture

21 January 2018

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Cardiac effects of relaxin in rats

21 January 2018

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Relaxin-induced increased coronary flow through stimulation of nitric oxide production.

21 January 2018

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Relaxin influences the growth of MCF-7 breast cancer cells. Mitogenic and antimitogenic action depends on peptide concentration

21 January 2018

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The kidney in normal pregnancy and preeclampsia

21 January 2018

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Anatomic and functional changes of the upper urinary tract during pregnancy

21 January 2018

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21 January 2018

Kidney and preeclampsia

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Role of relaxin in maternal systemic and renal vascular adaptations during gestation

21 January 2018

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Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia

21 January 2018

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Renal function during normal pregnancy and preeclampsia

21 January 2018

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New markers in preeclampsia

21 January 2018

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Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies

21 January 2018

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Aging attenuates the vasodilator response to relaxin.

21 January 2018

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Are we getting closer to a Nobel prize for unraveling preeclampsia?

21 January 2018

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New aspects in the pathophysiology of preeclampsia

21 January 2018

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Scientific rationale and design of a phase I safety study of relaxin in women with severe preeclampsia

21 January 2018

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Mechanisms of relaxin receptor (LGR7/RXFP1) expression and function

21 January 2018

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Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules

21 January 2018

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Second trimester neutrophil gelatinase-associated lipocalin as a potential prediagnostic marker of preeclampsia

21 January 2018

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Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide

21 January 2018

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The pregnancy hormone relaxin is a player in human heart failure.

21 January 2018

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Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB.

21 January 2018

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Relaxin regulates vascular wall remodeling and passive mechanical properties in mice

21 January 2018

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The vascular actions of relaxin

21 January 2018

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Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(ω)-nitro-L-arginine methyl ester hypertensive rats

21 January 2018

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Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

21 January 2018

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Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.

21 January 2018

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The positive inotropic effect of relaxin-2 in human atrial myocardium is preserved in end-stage heart failure: role of G(i)-phosphoinositide-3 kinase signaling.

21 January 2018

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Cardiovascular effects of relaxin: from basic science to clinical therapy

21 January 2018

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Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease

21 January 2018

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Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype.

21 January 2018

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Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

21 January 2018

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Relaxin-1-deficient mice develop an age-related progression of renal fibrosis

21 January 2018

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Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis

21 January 2018

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Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

21 January 2018

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Relaxin decreases renal interstitial fibrosis and slows progression of renal disease

21 January 2018

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Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin

21 January 2018

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Inhibition of markers of hepatic stellate cell activation by the hormone relaxin

21 January 2018

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The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease

21 January 2018

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Recombinant relaxin: a review of pharmacology and potential therapeutic use.

21 January 2018

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Rational therapy in the treatment of systemic sclerosis

21 January 2018

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Treatment of systemic sclerosis

21 January 2018

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Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

21 January 2018

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Airway fibrosis in a mouse model of airway inflammation.

21 January 2018

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Relaxin: an endogenous renoprotective factor?

21 January 2018

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Effect of relaxin in two models of renal mass reduction

21 January 2018

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Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

21 January 2018

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Relaxin and the progression of kidney disease.

21 January 2018

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TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.

21 January 2018

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Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

21 January 2018

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Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity

21 January 2018

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Effect of relaxin on TGF-beta1 expression in cultured vaginal fibroblasts from women with stress urinary incontinence

21 January 2018

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Transforming growth factor-beta is a potent inhibitor of basal and stimulated relaxin release by porcine luteal cells maintained in monolayer culture

21 January 2018

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Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds

21 January 2018

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Down with the erythropoietin. Long live the erythropoietin!

21 January 2018

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Regenerative medicine: does Erythropoietin have a role?

21 January 2018

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Relaxin regulates MMP expression and promotes satellite cell mobilization during muscle healing in both young and aged mice.

21 January 2018

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Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

21 January 2018

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Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

21 January 2018

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Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans

21 January 2018

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Experimental models of acute renal failure and erythropoietin: what evidence of a direct effect?

21 January 2018

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Relaxin stimulates osteoclast differentiation and activation

21 January 2018

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Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts

21 January 2018

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Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis

21 January 2018

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Relaxin is a key mediator of prostate growth and male reproductive tract development

21 January 2018

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Investigation of the local expression of the relaxin system in canine mammary tumours

21 January 2018

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Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts

21 January 2018

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Relaxin promotes prostate cancer progression

21 January 2018

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Relaxin/RXFP1 signaling in prostate cancer progression

21 January 2018

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Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer

21 January 2018

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Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis

21 January 2018

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Relaxin receptors--new drug targets for multiple disease states

21 January 2018

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Relaxin enhances in-vitro invasiveness of breast cancer cell lines by up-regulation of matrix metalloproteases

21 January 2018

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Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth

21 January 2018

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The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

21 January 2018

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Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab

21 January 2018

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Relaxin is a potent renal vasodilator in conscious rats

21 January 2018

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The dipsogenic effects of rat relaxin: The effect of photoperiod and the potential role of relaxin on drinking in pregnancy

21 January 2018

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Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis.

21 January 2018

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Relaxin-induced changes in renal sodium excretion in the anesthetized male rat.

21 January 2018

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Identification of Relaxin-3/INSL7 as a Ligand for GPCR142

21 January 2018

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Relaxin-3 and its role in neuroendocrine function

21 January 2018

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The central corticotropin releasing factor system during development and adulthood

21 January 2018

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Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress

21 January 2018

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Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake

21 January 2018

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Central relaxin-3 administration causes hyperphagia in male Wistar rats

21 January 2018

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Relaxin-3/insulin-like peptide 7, a neuropeptide involved in the stress response and food intake

21 January 2018

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In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency

21 January 2018

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Design of the RELAXin in acute heart failure study.

21 January 2018

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Fibrosis, regeneration and cancer: what is the link?

21 January 2018

1 reference

First clinical experience with intravenous recombinant human relaxin in compensated heart failure

21 January 2018

1 reference

Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial.

21 January 2018

1 reference

Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial.

21 January 2018

1 reference

A randomized, placebo-controlled clinical trial on the effects of recombinant human relaxin on tooth movement and short-term stability

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21277

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28 August 2017

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