Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation (Q38081407)

28 August 2017

Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation (English)

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28 August 2017

Sara Manteiga

1

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28 August 2017

Kyungoh Choi

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2

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28 August 2017

Arul Jayaraman

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3

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28 August 2017

Kyongbum Lee

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4

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28 August 2017

language of work or name

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13 February 2013

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Wiley interdisciplinary reviews. Systems biology and medicine

28 August 2017

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28 August 2017

5

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28 August 2017

4

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28 August 2017

425-447

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Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010

28 August 2017

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Guidelines for healthy weight

21 January 2018

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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Adipose precursor cells (preadipocytes) induce formation of new vessels in fibrin glue on the newly developed cylinder chorioallantoic membrane model (CAM).

21 January 2018

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Angiogenesis modulates adipogenesis and obesity

21 January 2018

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Adipose tissue growth and regression are regulated by angiopoietin-1

21 January 2018

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Fatty acid synthesis by human adipose tissue

21 January 2018

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How fatty acids of different chain length enter and leave cells by free diffusion

21 January 2018

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Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4.

21 January 2018

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Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

21 January 2018

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FATP1 mediates fatty acid-induced activation of AMPK in 3T3-L1 adipocytes

21 January 2018

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Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

21 January 2018

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mTOR signaling in growth control and disease

21 January 2018

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Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

21 January 2018

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Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue

21 January 2018

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Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation

21 January 2018

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SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

21 January 2018

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The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue

21 January 2018

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Activation of liver X receptor regulates substrate oxidation in white adipocytes

21 January 2018

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De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation.

21 January 2018

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GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis

21 January 2018

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Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

21 January 2018

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Functional analysis of long-chain acyl-CoA synthetase 1 in 3T3-L1 adipocytes

21 January 2018

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Long chain acyl CoA synthetase 1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis

21 January 2018

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Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

21 January 2018

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

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Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis

21 January 2018

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Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo

21 January 2018

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Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.

21 January 2018

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Increased glucose uptake in visceral versus subcutaneous adipose tissue revealed by PET imaging

21 January 2018

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Depot-specific effects of the PPARgamma agonist rosiglitazone on adipose tissue glucose uptake and metabolism.

21 January 2018

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Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism

21 January 2018

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Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast

21 January 2018

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A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases

21 January 2018

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Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice

21 January 2018

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Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue

21 January 2018

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Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

21 January 2018

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Growth hormone, insulin-like growth factor-I and lipid metabolism: interactions with sex steroids

21 January 2018

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Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin

21 January 2018

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Hormone-sensitive lipase modulates adipose metabolism through PPARγ.

21 January 2018

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CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome

21 January 2018

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Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content

21 January 2018

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Regulation of lipolysis in small and large fat cells of the same subject

21 January 2018

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Rates of lipid fluxes in adipose tissue in vivo after a mixed meal in morbid obesity

21 January 2018

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Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

21 January 2018

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Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue

21 January 2018

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Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study

21 January 2018

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Respiration in adipocytes is inhibited by reactive oxygen species

21 January 2018

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Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes

21 January 2018

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Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

21 January 2018

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Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

21 January 2018

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Dynamics of fat cell turnover in humans

21 January 2018

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Dynamics of human adipose lipid turnover in health and metabolic disease

21 January 2018

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The biology of white adipocyte proliferation

21 January 2018

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Molecular regulation of adipogenesis

21 January 2018

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Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet

21 January 2018

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Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.

21 January 2018

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PLD1 and ERK2 regulate cytosolic lipid droplet formation

21 January 2018

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Involvement of cyclooxygenase-2 in synergistic effect of cyclic stretching and eicosapentaenoic acid on adipocyte differentiation

21 January 2018

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Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

21 January 2018

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Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies.

21 January 2018

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Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes

21 January 2018

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Lipid droplets in lipogenesis and lipolysis

21 January 2018

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Lipid droplets: a dynamic organelle moves into focus

21 January 2018

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Mechanisms of lipid-body formation

21 January 2018

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Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

21 January 2018

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A pilot study of a phenomenological model of adipogenesis in maturing adipocytes using Cahn-Hilliard theory

21 January 2018

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SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity

21 January 2018

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Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets

21 January 2018

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Remodeling of lipid droplets during lipolysis and growth in adipocytes

21 January 2018

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Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes

21 January 2018

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Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes

21 January 2018

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THE DIFFERENTIATION OF WHITE ADIPOSE CELLS. AN ELECTRON MICROSCOPE STUDY

21 January 2018

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Collagens: molecular biology, diseases, and potentials for therapy

21 January 2018

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Genetic link between obesity and MMP14-dependent adipogenic collagen turnover

21 January 2018

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Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans

21 January 2018

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Mechanotransduction in adipocytes

21 January 2018

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Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway

21 January 2018

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The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

21 January 2018

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Lipolysis response to endoplasmic reticulum stress in adipose cells

21 January 2018

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Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells

21 January 2018

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Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

21 January 2018

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Leptin, the product of Ob gene, promotes angiogenesis

21 January 2018

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Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.

21 January 2018

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Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis

21 January 2018

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Modulation of angiogenesis during adipose tissue development in murine models of obesity

21 January 2018

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Dichotomous effects of VEGF-A on adipose tissue dysfunction.

21 January 2018

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Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice

21 January 2018

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Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis

21 January 2018

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JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro

21 January 2018

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Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

21 January 2018

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FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

21 January 2018

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The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function

21 January 2018

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Roles for peroxisome proliferator-activated receptor γ (PPARγ) and PPARγ coactivators 1α and 1β in regulating response of white and brown adipocytes to hypoxia

21 January 2018

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Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet.

21 January 2018

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Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes

21 January 2018

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An emerging role of mTOR in lipid biosynthesis.

21 January 2018

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NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress.

21 January 2018

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Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

21 January 2018

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Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes

21 January 2018

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Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

21 January 2018

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Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

21 January 2018

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NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes

21 January 2018

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

21 January 2018

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High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation

21 January 2018

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A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

21 January 2018

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Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.

21 January 2018

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

21 January 2018

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Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

21 January 2018

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

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Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

21 January 2018

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Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

21 January 2018

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

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A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha

21 January 2018

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PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

21 January 2018

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Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages

21 January 2018

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Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

21 January 2018

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Alternative activation of macrophages

21 January 2018

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Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

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Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype

21 January 2018

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Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR.

21 January 2018

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Mechanisms of inflammatory responses in obese adipose tissue

21 January 2018

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Gut microbiota and diabetes: from pathogenesis to therapeutic perspective.

21 January 2018

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Obesity alters gut microbial ecology

21 January 2018

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Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents

21 January 2018

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The gut microbiota as an environmental factor that regulates fat storage

21 January 2018

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Metabolic endotoxemia initiates obesity and insulin resistance

21 January 2018

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

21 January 2018

1 reference

Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation

21 January 2018

1 reference

The endocannabinoid system links gut microbiota to adipogenesis

21 January 2018

1 reference

Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism

21 January 2018

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Role of body fat distribution and the metabolic complications of obesity

21 January 2018

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It's not how fat you are, it's what you do with it that counts

21 January 2018

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Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid

21 January 2018

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JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction

21 January 2018

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Enhanced A-FABP expression in visceral fat: potential contributor to the progression of NASH.

21 January 2018

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Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

21 January 2018

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

21 January 2018

1 reference

NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.

21 January 2018

1 reference

Proteome analysis of adipogenesis.

21 January 2018

1 reference

Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes

21 January 2018

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Proteomic analysis of 3T3-L1 adipocyte mitochondria during differentiation and enlargement

21 January 2018

1 reference

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)

21 January 2018

1 reference

A combination of protein profiling and isotopomer analysis using matrix-assisted laser desorption/ionization-time of flight mass spectrometry reveals an active metabolism of the extracellular matrix of 3T3-L1 adipocytes

21 January 2018

1 reference

Characterization of the human visceral adipose tissue secretome

21 January 2018

1 reference

Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake

21 January 2018

1 reference

Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors

21 January 2018

1 reference

Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics

21 January 2018

1 reference

Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone

21 January 2018

1 reference

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

21 January 2018

1 reference

Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice

21 January 2018

1 reference

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans

21 January 2018

1 reference

A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease.

21 January 2018

1 reference

Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice

21 January 2018

1 reference

A model of NEFA dynamics with focus on the postprandial state.

21 January 2018

1 reference

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control.

21 January 2018

1 reference

Impact of perturbed pyruvate metabolism on adipocyte triglyceride accumulation

21 January 2018

1 reference

Mathematical modeling of preadipocyte fate determination

21 January 2018

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In silico models of cancer

21 January 2018

1 reference

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

21 January 2018

1 reference

Adipose tissue as an endocrine organ

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WSBM.1213

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28 August 2017

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