Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells (Q38085694)

28 August 2017

Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells (English)

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28 August 2017

3

Pura Muñoz-Cánoves

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28 August 2017

Laura García-Prat

1

1 reference

PubMed ID

23452120

28 August 2017

Pedro Sousa-Victor

series ordinal

2

1 reference

PubMed ID

23452120

28 August 2017

language of work or name

English

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publication date

21 March 2013

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28 August 2017

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28 August 2017

280

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28 August 2017

4051-4062

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28 August 2017

17

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Niche science: the aging stem cell.

28 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cells in the hood: the skeletal muscle niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Satellite cells and the muscle stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Emerging models and paradigms for stem cell ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Translating stem and progenitor cell biology to the clinic: barriers and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Manifestations and mechanisms of stem cell aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Coexistence of quiescent and active adult stem cells in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Understanding the odd science of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cells, ageing and the quest for immortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cells, aging, and cancer: inevitabilities and outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The ageing immune system: is it ever too old to become young again?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cell heterogeneity: implications for aging and regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Age-associated characteristics of murine hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Cell intrinsic alterations underlie hematopoietic stem cell aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

How stem cells age and why this makes us grow old.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Apoptosis and aging: role of the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

DNA damage checkpoints in stem cells, ageing and cancer.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12221

Relationship between DNA Repair Capacity and Cellular Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Does oxidative damage to DNA increase with age?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Repopulating defect of mismatch repair–deficient hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Aging and genome maintenance: lessons from the mouse?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Deletion of Ku86 causes early onset of senescence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

DNA damage foci at dysfunctional telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The longest telomeres: a general signature of adult stem cell compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Intrinsic changes and extrinsic influences of myogenic stem cell function during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The complex language of chromatin regulation during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Sirtuins in aging and age-related disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Widespread and tissue specific age-related DNA methylation changes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Tissue-specific dysregulation of DNA methylation in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Investigating stem cells in human colon by using methylation patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A common somitic origin for embryonic muscle progenitors and satellite cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Pax3/Pax7 mark a novel population of primitive myogenic cells during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Non-passaged muscle precursor cells from 32-month old rat skeletal muscle have delayed proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cell review series: aging of the skeletal muscle stem cell niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Stem cells for skeletal muscle repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Culture of skeletal myoblasts from human donors aged over 40 years: dynamics of cell growth and expression of differentiation markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A population of myogenic stem cells that survives skeletal muscle aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Loss of stem cell regenerative capacity within aged niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The regeneration of noninnervated muscle grafts and marcaine-treated muscles in young and old rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Adipogenesis and aging: does aging make fat go MAD?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Alterations in the TGFbeta signaling pathway in myogenic progenitors with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Delaying the mitochondrial decay of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Oxidative stress and aging: beyond correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Short-term calorie restriction enhances skeletal muscle stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Gene expression profiling of human satellite cells during muscular aging using cDNA arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The biology of satellite cells and telomeres in human skeletal muscle: effects of aging and physical activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Notch signaling is necessary to maintain quiescence in adult muscle stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

The aged niche disrupts muscle stem cell quiescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Muscle stem cells and reversible quiescence: the role of sprouty

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Heterogeneity in the muscle satellite cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Long-term erythropoietic repopulating ability of old, young, and fetal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Regulating the Notch pathway in embryonic, adult and old stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Phagocytosis of necrotic muscle in muscle isografts is influenced by the strain, age, and sex of host mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Molecular mechanisms of aging-associated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Inflammatory processes in muscle injury and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Identification of a molecular signature of sarcopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12221

21 January 2018

Identifiers

DOI

10.1111/FEBS.12221

1 reference

28 August 2017

1 reference

PubMed ID

23452120