BIM, PUMA, and the achilles' heel of oncogene addiction (Q38093430)

28 August 2017

title

BIM, PUMA, and the achilles' heel of oncogene addiction (English)

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28 August 2017

Anne Roulston

1

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28 August 2017

William J Muller

series ordinal

2

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28 August 2017

Gordon C Shore

series ordinal

3

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28 August 2017

publication date

26 March 2013

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28 August 2017

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28 August 2017

volume

6

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28 August 2017

issue

268

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28 August 2017

page(s)

pe12

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Shifting paradigms: the seeds of oncogene addiction

28 August 2017

cites work

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Induction of apoptosis in fibroblasts by c-myc protein

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PUMA and BIM are required for oncogene inactivation-induced apoptosis.

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Bcl-2 family proteins and cancer

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

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The BCL-2 protein family: opposing activities that mediate cell death

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Cell death: critical control points

21 January 2018

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Genomic predictors of outcome and treatment response in breast cancer

21 January 2018

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

21 January 2018

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

21 January 2018

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BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

21 January 2018

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

21 January 2018

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Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

21 January 2018

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

21 January 2018

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

21 January 2018

1 reference

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Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression

21 January 2018

1 reference

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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

21 January 2018

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FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

21 January 2018

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FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 January 2018

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FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

21 January 2018

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A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation

21 January 2018

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Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway

21 January 2018

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FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

21 January 2018

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FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma

21 January 2018

1 reference

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The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival

21 January 2018

1 reference

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c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004113

Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

21 January 2018

1 reference

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10.1126/SCISIGNAL.2004113

21 January 2018

Identifiers

DOI

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28 August 2017

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