Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid (Q38113683)

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scientific article published on 12 June 2013

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English	Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid	scientific article published on 12 June 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 August 2017

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid (English)

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Europe PubMed Central

PubMed publication ID

29 August 2017

cerebrospinal fluid

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Henrik Zetterberg

2

object named as

Henrik Zetterberg

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Europe PubMed Central

PubMed publication ID

29 August 2017

4

object named as

Kaj Blennow

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Europe PubMed Central

PubMed publication ID

29 August 2017

author name string

Heiko Braak

1

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Europe PubMed Central

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29 August 2017

Kelly Del Tredici

3

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Europe PubMed Central

PubMed publication ID

29 August 2017

publication date

12 June 2013

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Europe PubMed Central

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29 August 2017

Acta Neuropathologica

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Europe PubMed Central

PubMed publication ID

29 August 2017

126

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Europe PubMed Central

PubMed publication ID

29 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

631-641

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Europe PubMed Central

PubMed publication ID

29 August 2017

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease.

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The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

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Microtubule transport in the axon

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Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease

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Cerebrospinal fluid protein biomarkers for Alzheimer's disease

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Longitudinal stability of CSF biomarkers in Alzheimer's disease.

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Duration of neurofibrillary changes in the hippocampal pyramidal neurons

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Neuropathological stageing of Alzheimer-related changes

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Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation

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Where, when, and in what form does sporadic Alzheimerʼs disease begin?

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Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia

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CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

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Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

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Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

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Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing

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Advance in the pathogenesis and treatment of Wilson disease

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Classification and basic pathology of Alzheimer disease

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Hyperphosphorylated tau in young and middle-aged subjects

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Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

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Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

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Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

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Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid

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Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment

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Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women

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The magical number four: A biological, historical and mythological enigma

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke.

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Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Transition of tau protein from disordered to misordered in Alzheimer's disease.

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

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Structural principles of tau and the paired helical filaments of Alzheimer's disease

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Neuropathologic substrate of mild cognitive impairment.

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Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.

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The spectrum of disease in chronic traumatic encephalopathy

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Neurons may live for decades with neurofibrillary tangles

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Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.

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Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

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Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

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Membrane trafficking pathways in Alzheimer's disease

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Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity.

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Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology.

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Alzheimer's disease: a central role for amyloid

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

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How can we recognize "disease modification" effects?

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Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly.

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CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study

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Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease

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Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

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Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type

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Sequence of Abeta-protein deposition in the human medial temporal lobe.

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PET amyloid-beta imaging in preclinical Alzheimer's disease

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Tau aggregation is driven by a transition from random coil to beta sheet structure

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Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

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10.1007/S00401-013-1139-0

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Europe PubMed Central

PubMed publication ID

29 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

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