Caspase-6 as a novel early target in the treatment of Alzheimer's disease (Q38114942)

29 August 2017

title

Caspase-6 as a novel early target in the treatment of Alzheimer's disease (English)

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29 August 2017

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Andrea C LeBlanc

1

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29 August 2017

language of work or name

English

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publication date

1 June 2013

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European Journal of Neuroscience

29 August 2017

published in

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29 August 2017

volume

37

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29 August 2017

issue

12

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29 August 2017

page(s)

2005-2018

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

29 August 2017

cites work

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Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

21 January 2018

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Activation of caspase-6 in aging and mild cognitive impairment

21 January 2018

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Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations

21 January 2018

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Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis.

21 January 2018

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Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

21 January 2018

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Semantic dementia associated with mutation V363I in the tau gene

21 January 2018

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Frequency of stages of Alzheimer-related lesions in different age categories

21 January 2018

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

21 January 2018

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Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.

21 January 2018

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Caspase activation precedes and leads to tangles

21 January 2018

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Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays

21 January 2018

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Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy

21 January 2018

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Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.

21 January 2018

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Proapoptotic effects of tau cleavage product generated by caspase-3.

21 January 2018

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Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death

21 January 2018

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Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

21 January 2018

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Caspase-3 in the central nervous system: beyond apoptosis

21 January 2018

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

21 January 2018

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Identification of normal and pathological aging in prospectively studied nondemented elderly humans

21 January 2018

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Classification and basic pathology of Alzheimer disease

21 January 2018

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An optimized activity-based probe for the study of caspase-6 activation

21 January 2018

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A quantitative method for the specific assessment of caspase-6 activity in cell culture

21 January 2018

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Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra

21 January 2018

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Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development

21 January 2018

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Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study.

21 January 2018

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Caspase cleavage of members of the amyloid precursor family of proteins

21 January 2018

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

21 January 2018

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Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

21 January 2018

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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

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Ubiquitinated granular structures and initial neurofibrillary changes in the human brain.

21 January 2018

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Of mice and men: bridging the translational disconnect in CNS drug discovery

21 January 2018

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Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain

21 January 2018

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Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology

21 January 2018

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Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides

21 January 2018

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Activation of specific apoptotic caspases with an engineered small-molecule-activated protease

21 January 2018

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The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk

21 January 2018

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Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway

21 January 2018

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Valosin-containing protein gene mutations: clinical and neuropathologic features

21 January 2018

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Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation

21 January 2018

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Neuropathology in the S305S tau gene mutation.

21 January 2018

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Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease

21 January 2018

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Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein

21 January 2018

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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

21 January 2018

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Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures

21 January 2018

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Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

21 January 2018

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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

21 January 2018

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Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.

21 January 2018

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Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

21 January 2018

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The effects of aging on gene expression in the hypothalamus and cortex of mice

21 January 2018

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

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Ubiquitin regulates GGA3-mediated degradation of BACE1

21 January 2018

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Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease.

21 January 2018

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Targets of caspase-6 activity in human neurons and Alzheimer disease

21 January 2018

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Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.

21 January 2018

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

21 January 2018

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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease

21 January 2018

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Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A

21 January 2018

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Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

21 January 2018

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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

21 January 2018

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Apoptotic threshold is lowered by p53 transactivation of caspase-6

21 January 2018

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

21 January 2018

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

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A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

21 January 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

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21 January 2018

The many faces of tau

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

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MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival

21 January 2018

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Sequence-based discovery of a synthetic peptide inhibitor of caspase 6.

21 January 2018

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Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells

21 January 2018

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Caspase activity is required for stimulated B lymphocytes to enter the cell cycle

21 January 2018

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The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

21 January 2018

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Two distinct types of dying back axonal degeneration in vitro.

21 January 2018

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Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice

21 January 2018

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p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

21 January 2018

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Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

21 January 2018

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

21 January 2018

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Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

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Caspase-6 activity predicts lower episodic memory ability in aged individuals

21 January 2018

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Effects of environmental enrichment on gene expression in the brain

21 January 2018

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Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation

21 January 2018

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Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

21 January 2018

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

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Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

21 January 2018

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Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

21 January 2018

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Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

21 January 2018

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Where vascular meets neurodegenerative disease

21 January 2018

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Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals

21 January 2018

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The ubiquitin-proteasome pathway and pathogenesis of human diseases

21 January 2018

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Alzheimer's disease: genotypes, phenotypes, and treatments

21 January 2018

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In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

21 January 2018

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Synapses and Alzheimer's disease

21 January 2018

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Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

21 January 2018

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Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

21 January 2018

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A caspase cascade regulating developmental axon degeneration

21 January 2018

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Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures

21 January 2018

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The tau S305S mutation causes frontotemporal dementia with parkinsonism

21 January 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

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Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutation

21 January 2018

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The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.

21 January 2018

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The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

21 January 2018

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Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

21 January 2018

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Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

21 January 2018

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Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

21 January 2018

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Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

21 January 2018

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21 January 2018

Alzheimer's mutation.

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Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

21 January 2018

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

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Phases of A beta-deposition in the human brain and its relevance for the development of AD.

21 January 2018

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Proteasomal degradation of caspase-6 in 17beta-estradiol-treated neurons

21 January 2018

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Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases

21 January 2018

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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

21 January 2018

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Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

21 January 2018

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Zinc-mediated Allosteric Inhibition of Caspase-6

21 January 2018

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Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

21 January 2018

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Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway

21 January 2018

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Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1

21 January 2018

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Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

21 January 2018

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Caspase 6 regulates B cell activation and differentiation into plasma cells

21 January 2018

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

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Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

21 January 2018

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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

21 January 2018

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

21 January 2018

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Role of the executioner caspases during lens development.

21 January 2018

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Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience

21 January 2018

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Role of caspase-3 in tau truncation at D421 is restricted in transgenic mouse models for tauopathies

21 January 2018

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Caspase knockouts: matters of life and death.

21 January 2018

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Divinations and surprises: genetic analysis of caspase function in mice

21 January 2018

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

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Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

21 January 2018

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/EJN.12250

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29 August 2017

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