Origins of aberrant DNA methylation in acute myeloid leukemia (Q38130091)

29 August 2017

title

Origins of aberrant DNA methylation in acute myeloid leukemia (English)

1 reference

29 August 2017

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1 reference

T Schoofs

1

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29 August 2017

W E Berdel

series ordinal

2

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29 August 2017

C Müller-Tidow

series ordinal

3

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29 August 2017

publication date

20 August 2013

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29 August 2017

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29 August 2017

volume

28

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29 August 2017

issue

1

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29 August 2017

page(s)

1-14

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X inactivation, differentiation, and DNA methylation

29 August 2017

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IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives

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Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

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Regional activation of the cancer genome by long-range epigenetic remodeling

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Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

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The relationship of DNA methylation with age, gender and genotype in twins and healthy controls

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Genome-wide methylation profiles reveal quantitative views of human aging rates

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Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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DNA methylation: roles in mammalian development

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DNA methylation as a pathogenic event and as a therapeutic target in AML.

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DNA methylation in cancer: too much, but also too little

21 January 2018

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Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia.

21 January 2018

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The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Genetic alterations during colorectal-tumor development

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Minor clone provides a reservoir for relapse in multiple myeloma

21 January 2018

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Clonal evolution in cancer

21 January 2018

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Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.

21 January 2018

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

21 January 2018

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Exploring the genomes of cancer cells: progress and promise

21 January 2018

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The genomic landscapes of human breast and colorectal cancers

21 January 2018

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Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host

21 January 2018

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Inferring rules of lineage commitment in haematopoiesis

21 January 2018

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

21 January 2018

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DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

21 January 2018

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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

21 January 2018

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 January 2018

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

21 January 2018

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Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

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Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group

21 January 2018

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip

21 January 2018

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Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia

21 January 2018

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PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

21 January 2018

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Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

Targeting epigenetic programs in MLL-rearranged leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

In focus: MLL-rearranged leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

21 January 2018

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Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

21 January 2018

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia

21 January 2018

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Cooperating gene mutations in acute myeloid leukemia: a review of the literature.

21 January 2018

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Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

21 January 2018

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CEBPA point mutations in hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

21 January 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.242

DNA methylation: TET proteins-guardians of CpG islands?

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

DNA demethylation dynamics

21 January 2018

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.242

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

21 January 2018

1 reference

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Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation

21 January 2018

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Array-based genomic resequencing of human leukemia

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De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells

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Dnmt3a is essential for hematopoietic stem cell differentiation

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Telomeres shorten during ageing of human fibroblasts

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Meta-analysis of age-related gene expression profiles identifies common signatures of aging.

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Increased cell-to-cell variation in gene expression in ageing mouse heart

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Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

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Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

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Age-associated DNA methylation in pediatric populations

21 January 2018

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Distinct DNA methylomes of newborns and centenarians

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DNA methylation profiles in monozygotic and dizygotic twins.

21 January 2018

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Dynamic DNA methylation programs persistent adverse effects of early-life stress

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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

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Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

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Epigenetic abnormalities in cancer find a "home on the range"

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Chromosome territories, nuclear architecture and gene regulation in mammalian cells

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

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Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

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Replication timing-related and gene body-specific methylation of active human genes.

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A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

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Cohesin, a chromatin engagement ring

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The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development.

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Cohesin organizes chromatin loops at DNA replication factories.

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Dynamic DNA methylation across diverse human cell lines and tissues

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Perspectives and future directions for epigenetics in hematology

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The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

21 January 2018

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Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study

21 January 2018

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

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Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

21 January 2018

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Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

21 January 2018

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12 December 2020

DNA-binding factors shape the mouse methylome at distal regulatory regions

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12 December 2020

Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia

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12 December 2020

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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12 December 2020

DNA modification mechanisms and gene activity during development

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12 December 2020

Toward personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML.

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12 December 2020

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

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12 December 2020

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

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12 December 2020

Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications

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12 December 2020

Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity

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12 December 2020

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

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12 December 2020

Newly diagnosed adult AML and MPAL patients frequently show clonal residual hematopoiesis.

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12 December 2020

Chemistry. How are alkynes scrambled?

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/LEU.2013.242

1 reference

Dimensions Publication ID

29 August 2017

1051355543

0 references

1 reference