Bile acid receptors as targets for drug development. (Q38132058)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23982684%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Bile acid receptors as targets for drug development (English)

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8 March 2020

1

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8 March 2020

author name string

Michael Trauner

series ordinal

2

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8 March 2020

Peter L M Jansen

series ordinal

3

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language of work or name

English

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publication date

27 August 2013

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Nature Reviews Gastroenterology & Hepatology

8 March 2020

published in

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8 March 2020

volume

11

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8 March 2020

issue

1

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8 March 2020

page(s)

55-67

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https://scigraph.springernature.com/pub.10.1038/nrgastro.2013.151

8 March 2020

exact match

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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

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Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

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Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.

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Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice

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Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

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Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

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Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice

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Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

21 January 2018

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The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.

21 January 2018

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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

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Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).

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The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

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The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

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The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

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TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

21 January 2018

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The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

21 January 2018

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Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

21 January 2018

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TGR5-mediated bile acid sensing controls glucose homeostasis

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The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

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Role of CAR and PXR in xenobiotic sensing and metabolism

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Nuclear receptor PXR, transcriptional circuits and metabolic relevance

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The PXR is a drug target for chronic inflammatory liver disease

21 January 2018

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Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

21 January 2018

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

21 January 2018

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Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

21 January 2018

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FXR and PXR: potential therapeutic targets in cholestasis.

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Minireview: vitamin D receptor: new assignments for an already busy receptor

21 January 2018

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Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes

21 January 2018

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Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

21 January 2018

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The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro

21 January 2018

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A novel bile acid-activated vitamin D receptor signaling in human hepatocytes

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Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium

21 January 2018

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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

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Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines

21 January 2018

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Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

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Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

21 January 2018

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Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

21 January 2018

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

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Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

21 January 2018

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Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.

21 January 2018

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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

21 January 2018

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Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

21 January 2018

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Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice

21 January 2018

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Antiatherosclerotic effect of farnesoid X receptor

21 January 2018

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A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

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FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

21 January 2018

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Effects of FXR in foam-cell formation and atherosclerosis development

21 January 2018

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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

21 January 2018

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Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

21 January 2018

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Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action

21 January 2018

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Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.

21 January 2018

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EASL Clinical Practice Guidelines: management of cholestatic liver diseases.

21 January 2018

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Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver

21 January 2018

1 reference

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Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats

21 January 2018

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α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes.

21 January 2018

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Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man

21 January 2018

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TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

21 January 2018

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Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.

21 January 2018

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Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435.

21 January 2018

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Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase

21 January 2018

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Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: a 24-week randomized controlled trial

21 January 2018

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Effect of bile acid sequestrants on glycaemic control: protocol for a systematic review with meta-analysis of randomised controlled trials

21 January 2018

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High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

21 January 2018

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Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

21 January 2018

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Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.

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Lysophosphatidic acid is a potential mediator of cholestatic pruritus

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Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions.

21 January 2018

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The TGR5 receptor mediates bile acid-induced itch and analgesia

21 January 2018

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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

21 January 2018

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Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea

21 January 2018

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Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model

21 January 2018

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Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial.

21 January 2018

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Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity

21 January 2018

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Identification of a nuclear receptor for bile acids

21 January 2018

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A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

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Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)

21 January 2018

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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

21 January 2018

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Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene

21 January 2018

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Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B.

21 January 2018

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Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

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Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice

21 January 2018

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Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

21 January 2018

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

21 January 2018

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Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?

21 January 2018

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Chenodeoxycholic acid inhibits increased cholesterol and cholestanol synthesis in patients with cerebrotendinous Xanthomatosis

31 March 2020

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Effect of Jaundice on Rheumatoid Arthritis

31 March 2020

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Identification of a nuclear receptor that is activated by farnesol metabolites

31 March 2020

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Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy

31 March 2020

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Pregnane X receptor is a target of farnesoid X receptor

31 March 2020

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Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

31 March 2020

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Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

31 March 2020

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Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

31 March 2020

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Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists

31 March 2020

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p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ

31 March 2020

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Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

31 March 2020

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Effects of corticosteroids on bilirubin metabolism in patients with Gilbert's syndrome

31 March 2020

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Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin

31 March 2020

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Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-)

31 March 2020

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Ursodeoxycholic acid treatment of gallstones. Dose-response study and possible mechanism of action

31 March 2020

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