Advances and challenges in gene-based approaches for osteoarthritis (Q38134331)

29 August 2017

Advances and challenges in gene-based approaches for osteoarthritis (English)

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29 August 2017

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2

Magali Cucchiarini

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29 August 2017

Henning Madry

1

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29 August 2017

1 October 2013

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29 August 2017

Journal of Gene Medicine

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29 August 2017

15

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29 August 2017

10

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29 August 2017

343-355

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The Global Economic Cost of Osteoarthritis: How the UK Compares

29 August 2017

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Financial cost of osteoarthritis in France. The "COART" France study

21 January 2018

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21 January 2018

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OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009.

21 January 2018

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Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis

21 January 2018

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Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

21 January 2018

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Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage

21 January 2018

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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

21 January 2018

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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

21 January 2018

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Biological aspects of early osteoarthritis

21 January 2018

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Genetic epidemiology of hip and knee osteoarthritis

21 January 2018

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Biomechanical factors in osteoarthritis

21 January 2018

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Mechanotransduction and cartilage integrity

21 January 2018

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Effects of aging on articular cartilage homeostasis

21 January 2018

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Osteoarthritis year 2010 in review: pathomechanisms

21 January 2018

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Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

21 January 2018

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The elusive path to cartilage regeneration

21 January 2018

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Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer

21 January 2018

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Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis

21 January 2018

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Arthritis gene therapy and its tortuous path into the clinic

21 January 2018

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Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation

21 January 2018

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Clinical potential and challenges of using genetically modified cells for articular cartilage repair

21 January 2018

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Gene therapy for cartilage defects

21 January 2018

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Gene Therapy for Cartilage Repair

21 January 2018

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Maturation of the adrenal medulla—IV

21 January 2018

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Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro

21 January 2018

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Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene

21 January 2018

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A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer

21 January 2018

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Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury

21 January 2018

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The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage

21 January 2018

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Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

21 January 2018

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Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation

21 January 2018

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Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy

21 January 2018

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In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

21 January 2018

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Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome

21 January 2018

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Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells

21 January 2018

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Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.

21 January 2018

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Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair

21 January 2018

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SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

21 January 2018

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Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo

21 January 2018

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Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2.

21 January 2018

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rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions

21 January 2018

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Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

21 January 2018

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Growth factor transgenes interactively regulate articular chondrocytes

21 January 2018

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Anti-apoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis

21 January 2018

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Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis

21 January 2018

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Recombinant adeno-associated virus vector hybrids efficiently target different skeletal cells

21 January 2018

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Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

21 January 2018

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Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

21 January 2018

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α-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex

21 January 2018

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Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair

21 January 2018

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Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function

21 January 2018

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Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

21 January 2018

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Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model

21 January 2018

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Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation

21 January 2018

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Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation

21 January 2018

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Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo

21 January 2018

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Gene mediated insulin-like growth factor-I delivery to the synovium

21 January 2018

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Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.

21 January 2018

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Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer

21 January 2018

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Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

21 January 2018

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Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells

21 January 2018

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Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering

21 January 2018

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The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13.

21 January 2018

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Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

21 January 2018

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MicroRNA-140 plays dual roles in both cartilage development and homeostasis

21 January 2018

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Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.

21 January 2018

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Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

21 January 2018

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Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach

21 January 2018

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Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector

21 January 2018

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Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation

21 January 2018

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Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo

21 January 2018

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Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

21 January 2018

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Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

21 January 2018

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Gene therapy in musculoskeletal repair.

21 January 2018

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Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-β-mediated chondrocyte proliferation and proteoglycan synthesis

21 January 2018

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In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

21 January 2018

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Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

21 January 2018

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Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo

21 January 2018

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Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs

21 January 2018

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Co-transduction of lentiviral and adenoviral vectors for co-delivery of growth factor and shRNA genes in mesenchymal stem cells-based chondrogenic system.

21 January 2018

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Osteoarthritis gene therapy

21 January 2018

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Efficient lipid-mediated gene transfer to articular chondrocytes

21 January 2018

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Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells

21 January 2018

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LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.

21 January 2018

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In vivo gene delivery to synovium by lentiviral vectors.

21 January 2018

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Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease

21 January 2018

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

21 January 2018

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Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis

21 January 2018

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scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

21 January 2018

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The AAV vector toolkit: poised at the clinical crossroads

21 January 2018

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Adeno-associated virus vectorology, manufacturing, and clinical applications

21 January 2018

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Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

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In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis

21 January 2018

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Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

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Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain

21 January 2018

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TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.

21 January 2018

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Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection

21 January 2018

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Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer

21 January 2018

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Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10.

21 January 2018

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Gene therapies for osteoarthritis

21 January 2018

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Gene therapy for arthritis: what next?

21 January 2018

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Arthritis gene therapy's first death

21 January 2018

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Getting arthritis gene therapy into the clinic

21 January 2018

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Gene therapy for arthritis

21 January 2018

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Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study.

21 January 2018

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Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 Study

21 January 2018

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Investigation of the cause of death in a gene-therapy trial

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat.

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rabbit

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog.

21 January 2018

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Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis.

21 January 2018

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Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model.

21 January 2018

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Histopathology atlas of animal model systems - overview of guiding principles.

21 January 2018

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Recommendations for the use of preclinical models in the study and treatment of osteoarthritis.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JGM.2741

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29 August 2017

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PubMed ID

24006099