Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts (Q46294616)

21 December 2017

title

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts (English)

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21 December 2017

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Thomas F Chan

1

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21 December 2017

Denis Couchourel

2

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21 December 2017

Elie Abed

3

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21 December 2017

Aline Delalandre

4

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21 December 2017

Nicolas Duval

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21 December 2017

Daniel Lajeunesse

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21 December 2017

publication date

1 July 2011

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21 December 2017

Journal of Bone and Mineral Research

published in

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21 December 2017

volume

26

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21 December 2017

issue

7

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21 December 2017

page(s)

1399-1410

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21 December 2017

Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins.

cites work

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The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

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Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis

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Abnormal cancellous bone collagen metabolism in osteoarthritis

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Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

21 January 2018

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Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts

21 January 2018

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Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis

21 January 2018

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Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition

21 January 2018

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Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

21 January 2018

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Subchondral bone in osteoarthritis

21 January 2018

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Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis

21 January 2018

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Subchondral bone changes in hand and knee osteoarthritis detected by radiography

21 January 2018

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Function and biological roles of the Dickkopf family of Wnt modulators

21 January 2018

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21 January 2018

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Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

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Wnt/beta-catenin signaling in development and disease

21 January 2018

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A Wnt canon orchestrating osteoblastogenesis

21 January 2018

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pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.

21 January 2018

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

21 January 2018

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

21 January 2018

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Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts

21 January 2018

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Measurement of protein using bicinchoninic acid

21 January 2018

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Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone.

21 January 2018

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Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression

21 January 2018

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An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction

21 January 2018

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Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes.

21 January 2018

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Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.

21 January 2018

1 reference

The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces.

21 January 2018

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Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells

21 January 2018

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

21 January 2018

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Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

21 January 2018

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Mitogen activated protein kinase-dependent inhibition of osteocalcin gene expression by transforming growth factor-beta1.

21 January 2018

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TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

21 January 2018

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Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

21 January 2018

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Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

21 January 2018

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Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone

21 January 2018

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A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage.

21 January 2018

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Composition and Mechanical Properties of Cancellous Bone from the Femoral Head of Patients with Osteoporosis or Osteoarthritis

21 January 2018

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A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse model

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.358

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21 December 2017

PubMed ID

21312269

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21 December 2017