A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications (Q38149466)

29 August 2017

2 references

25 January 2021

20 October 2022

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications (English)

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29 August 2017

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bispecific antibodies

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25 January 2021

2

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1 June 2020

James C Whisstock

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3

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1 June 2020

author name string

Hannah Byrne

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1

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1 June 2020

Richard J O'Kennedy

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4

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publication date

2 October 2013

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24094861

29 August 2017

1 November 2013

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25 January 2021

20 October 2022

Trends in Biotechnology

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25 January 2021

20 October 2022

31

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11

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1 June 2020

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621-632

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A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells.

1 June 2020

cites work

1 reference

12 December 2020

Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism

1 reference

12 December 2020

CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation

1 reference

12 December 2020

Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

1 reference

12 December 2020

A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance

1 reference

12 December 2020

Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody

1 reference

12 December 2020

1 reference

12 December 2020

Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus

1 reference

12 December 2020

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

1 reference

12 December 2020

Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.

1 reference

12 December 2020

Continuous cultures of fused cells secreting antibody of predefined specificity

1 reference

12 December 2020

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

1 reference

12 December 2020

T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites

1 reference

12 December 2020

Effect of domain order on the activity of bacterially produced bispecific single-chain Fv antibodies.

1 reference

12 December 2020

Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains

1 reference

12 December 2020

Bispecific antibody pretargeting PET (immunoPET) with an 124I-labeled hapten-peptide.

1 reference

12 December 2020

Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China

1 reference

12 December 2020

The aetiology, origins, and diagnosis of severe acute respiratory syndrome.

1 reference

12 December 2020

Detection of Bordetella pertussis in a clinical laboratory by culture, polymerase chain reaction, and direct fluorescent antibody staining; accuracy, and cost.

1 reference

12 December 2020

Recombination of a mixture of univalent antibody fragments of different specificity

1 reference

12 December 2020

Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity.

1 reference

12 December 2020

Engineering a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells

1 reference

12 December 2020

Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties

1 reference

12 December 2020

Comparative evaluation of different chromogenic/fluorogenic media for detecting Escherichia coli O157:H7 in food

1 reference

12 December 2020

World Bispecific Antibody Summit, September 27-28, 2011, Boston, MA.

1 reference

12 December 2020

A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.

1 reference

12 December 2020

Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy

1 reference

12 December 2020

Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs

1 reference

12 December 2020

Development of new multivalent-bispecific agents for pretargeting tumor localization and therapy

1 reference

12 December 2020

Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein

1 reference

12 December 2020

Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody

1 reference

12 December 2020

Review of bats and SARS

1 reference

12 December 2020

A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system

1 reference

12 December 2020

Pretargeted gamma imaging of murine metastatic melanoma lung lesions with bispecific antibody and radiolabeled polymer drug conjugates.

1 reference

12 December 2020

Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug conjugates

1 reference

12 December 2020

Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single‐chain diabody (scDb) adapter that binds to fiber knob and HMWMAA

1 reference

12 December 2020

Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody

1 reference

12 December 2020

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

1 reference

12 December 2020

Hybrid hybridomas and their use in immunohistochemistry

1 reference

12 December 2020

Recombinant bispecific antibodies for the targeting of adenoviruses to CEA-expressing tumour cells: a comparative analysis of bacterially expressed single-chain diabody and tandem scFv

1 reference

12 December 2020

Engineered antibody fragments and the rise of single domains

1 reference

12 December 2020

Cancer therapy with trifunctional antibodies: linking innate and adaptive immunity

1 reference

12 December 2020

A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo

1 reference

12 December 2020

Effect of tetravalent bispecific CD19xCD3 recombinant antibody construct and CD28 costimulation on lysis of malignant B cells from patients with chronic lymphocytic leukemia by autologous T cells

1 reference

12 December 2020

Targeting very small model lesions pretargeted with bispecific antibody with 99mTc-labeled high-specific radioactivity polymers

1 reference

12 December 2020

Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing

1 reference

12 December 2020

Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting

1 reference

12 December 2020

A mutated superantigen SEA D227A fusion diabody specific to MUC1 and CD3 in targeted cancer immunotherapy for bile duct carcinoma.

1 reference

12 December 2020

The effect of variable domain orientation and arrangement on the antigen-binding activity of a recombinant human bispecific diabody

1 reference

12 December 2020

A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings

1 reference

12 December 2020

Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins

1 reference

12 December 2020

Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis

1 reference

12 December 2020

Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

1 reference

12 December 2020

Antigen-independent selection of stable intracellular single-chain antibodies

1 reference

12 December 2020

EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells

1 reference

12 December 2020

Recombinant bispecific antibodies for cancer therapy

1 reference

12 December 2020

The Bs20x22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone

1 reference

12 December 2020

A rapid point of care immunoswab assay for SARS-CoV detection

1 reference

12 December 2020

Therapeutic control of B cell activation via recruitment of Fcgamma receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold

1 reference

12 December 2020

Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished

1 reference

12 December 2020

A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors

1 reference

12 December 2020

Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model

1 reference

12 December 2020

Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity

1 reference

12 December 2020

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

1 reference

12 December 2020

Antibody production, design and use for biosensor-based applications

1 reference

12 December 2020

Bispecific antibody pretargeting of radionuclides for immuno single-photon emission computed tomography and immuno positron emission tomography molecular imaging: an update

1 reference

12 December 2020

T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct

1 reference

12 December 2020

Durable complete responses from therapy with combined epratuzumab and rituximab: final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma.

1 reference

12 December 2020

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

1 reference

12 December 2020

BiTEs: bispecific antibody constructs with unique anti-tumor activity

1 reference

12 December 2020

A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells.

1 reference

12 December 2020

A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis

1 reference

12 December 2020

Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation

1 reference

12 December 2020

Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a

1 reference

12 December 2020

A novel bispecific, trivalent antibody construct for targeting pancreatic carcinoma

1 reference

12 December 2020

CD19 as an attractive target for antibody-based therapy

1 reference

12 December 2020

Immunotherapeutic perspective for bispecific antibodies

1 reference

12 December 2020

Clinical impact of serum proteins on drug delivery

1 reference

12 December 2020

Bispecific antibodies for cancer immunotherapy: Current perspectives

1 reference

12 December 2020

A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data

1 reference

12 December 2020

Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion

1 reference

12 December 2020

Gene therapy for meningioma: improved gene delivery with targeted adenoviruses

1 reference

12 December 2020

Synergistic antitumor effect of bispecific CD19 x CD3 and CD19 x CD16 diabodies in a preclinical model of non-Hodgkin's lymphoma

1 reference

12 December 2020

Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells

1 reference

12 December 2020

MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

1 reference

12 December 2020

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.

1 reference

12 December 2020

Targeting of adenoviral vectors through a bispecific single-chain antibody

1 reference

12 December 2020

Chemical production of bispecific antibodies

1 reference

12 December 2020

Bispecific antibodies and ADCs: Once and future kings?

1 reference

12 December 2020

Growth kinetics of SARS-coronavirus in Vero E6 cells

1 reference

12 December 2020

Engineering of stable bispecific antibodies targeting IL-17A and IL-23.

1 reference

12 December 2020

Buy buy bispecific antibodies.

1 reference

12 December 2020

Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients

1 reference

12 December 2020

Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells

1 reference

12 December 2020

Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105).

1 reference

12 December 2020

A novel recombinant bispecific single-chain antibody, bscWue-1 x CD3, induces T-cell-mediated cytotoxicity towards human multiple myeloma cells

1 reference

12 December 2020

Bispecific single-chain diabody-mediated killing of endoglin-positive endothelial cells by cytotoxic T lymphocytes

1 reference

12 December 2020

A recombinant bispecific single-chain Fv antibody against HLA class II and FcgammaRIII (CD16) triggers effective lysis of lymphoma cells

1 reference

12 December 2020

Use of bispecific antibodies in molecular velcro assays whose specificity approaches the theoretical limit of immunodetection for Bordetella pertussis

1 reference

12 December 2020

Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis

1 reference

12 December 2020

Dual targeting strategies with bispecific antibodies

1 reference

12 December 2020

A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity

1 reference

12 December 2020

Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study

1 reference

12 December 2020

Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics

1 reference

12 December 2020

Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy

1 reference

12 December 2020

Human anti-self antibodies with high specificity from phage display libraries.

1 reference

12 December 2020

A modular IgG-scFv bispecific antibody topology

1 reference

12 December 2020

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

1 reference

12 December 2020

Transient lymphocyte decrease due to adhesion and migration following catumaxomab (anti-EpCAM x anti-CD3) treatment in vivo

1 reference

12 December 2020

Treatment of human B cell lymphoma xenografts with a CD3 x CD19 diabody and T cells

1 reference

12 December 2020

Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20 x anti-CD3 bispecific diabody

1 reference

12 December 2020

Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53

1 reference

12 December 2020

Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: a new strategy in the treatment of chronic inflammatory diseases and HIV.

1 reference

12 December 2020

Bispecific single-chain antibodies as effective tools for eliminating epithelial cancer cells from human stem cell preparations by redirected cell cytotoxicity

1 reference

12 December 2020

Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein x anti-CD3 diabody.

1 reference

12 December 2020

Quantitative and sensitive detection of the SARS-CoV spike protein using bispecific monoclonal antibody-based enzyme-linked immunoassay

1 reference

12 December 2020

Rituximab, an anti-cd20 monoclonal antibody: history and mechanism of action

1 reference

12 December 2020

A bispecific diabody directed against prostate-specific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells

1 reference

12 December 2020

A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils

1 reference

12 December 2020

Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response

1 reference

12 December 2020

Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules

1 reference

12 December 2020

Rapid detection of hepatitis B virus surface antigen by an agglutination assay mediated by a bispecific diabody against both human erythrocytes and hepatitis B virus surface antigen

1 reference

12 December 2020

Improved targeting of pancreatic cancer: experimental studies of a new bispecific antibody, pretargeting enhancement system for immunoscintigraphy

1 reference

12 December 2020

Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus

1 reference

12 December 2020

Imaging experimental atherosclerotic lesions in ApoE knockout mice: enhanced targeting with Z2D3-anti-DTPA bispecific antibody and 99mTc-labeled negatively charged polymers

1 reference

12 December 2020

T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent

1 reference

12 December 2020

The human antibody repertoire to infectious agents: implications for disease pathogenesis

1 reference

12 December 2020

Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma

1 reference

12 December 2020

Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy.

1 reference

12 December 2020

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.

1 reference

12 December 2020

Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format

1 reference

12 December 2020

Trifunctional bispecific antibodies induce tumor-specific T cells and elicit a vaccination effect.

1 reference

12 December 2020

Monospecific and bispecific antibodies against E. coli O157 for diagnostics.

1 reference

12 December 2020

Diagnostic tests for infectious diseases in the developing world: two sides of the coin

1 reference

12 December 2020

Combined effect of recombinant CD19 x CD16 diabody and thalidomide in a preclinical model of human B cell lymphoma

1 reference

12 December 2020

Immunofluorescence assay for serologic diagnosis of SARS

1 reference

12 December 2020

Bispecific antibody-mediated detection of the Staphylococcus aureus thermonuclease

1 reference

12 December 2020

Monoclonal antibodies

1 reference

12 December 2020

10.1016/J.TIBTECH.2013.08.007

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